Search Results - "Salakhutdinov, N. F"

The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo by Nikolin, V. P., Popova, N. A., Kaledin, V. I., Luzina, O. A., Zakharenko, A. L., Salakhutdinov, N. F., Lavrik, O. I.

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a repair enzyme for 3′-end DNA lesions, predominantly stalled DNA–topoisomerase 1 (Top1) cleavage complexes. Tdp1 is…”
Get full text

Stereoselective Cycloaddition of Alkanesulfonyl Chlorides to Dihydroberberine by Gladkova, E. D., Luzina, O. A., Salakhutdinov, N. F.

“…Novel berberine derivatives with annelated four-membered sulfone rings were synthesized. Cycloaddition of alkanesulfonyl chlorides to dihydroberberine occurred…”
Get full text

Enhancement of the Clastogenic Effects of Topotecan In Vivo by Tyrosyl-DNA Phosphodiesterase 1 Inhibitors by Zhanataev, A. K., Kulakova, A. V., Luzina, O. A., Khomenko, T. M., Volcho, K. P., Salakhutdinov, N. F., Durnev, A. D.

“…Topotecan administered intraperitoneally at single doses of 0.25, 0.5, and 1 mg/kg induced chromosomal aberrations in bone marrow cells of F 1 (CBA×C57BL/6)…”
Get full text

One-Pot Myrtenol Amination over Au, Au–Pd and Pd Nanoparticles Supported on Alumina by Demidova, Yu. S., Simakova, I. L., Estrada, M., Beloshapkin, S., Suslov, E. V., Volcho, K. P., Salakhutdinov, N. F., Simakov, A., Murzin, D. Yu

“…One-pot bio-based myrtenol amination was studied in the presence of alumina supported Au, Au–Pd and Pd nanoparticles subjected to the thermal treatment under…”
Get full text

Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan by Chepanova, A. A., Zakharenko, A. L., Dyrkheeva, N. S., Chernyshova, I. A., Zakharova, O. D., Ilina, E. S., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.

“…To date, various strategies have been proposed to increase the efficiency of cancer therapy. It is known that the action of DNA repair system can determine the…”
Get full text

Synthesis of Sulfones and Sulfoxides Based on (+)-usnic Acid by Sokolov, D. N., Luzina, O. A., Salakhutdinov, N. F.

“…Sulfones were produced by meta-chloroperbenzoic-acid oxidation of the corresponding thioethers prepared from (+)-usnic acid. Reaction of the thioethers with H…”
Get full text

Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2-Chromen-4,8-Diols Containing Alkyl-Substituted Aromatic Moieties by Patrusheva, O. S., Pavlova, A. V., Korchagina, D. V., Tolstikova, T. G., Volcho, K. P., Salakhutdinov, N. F.

“…A series of new heterocyclic compounds with the hexahydro-2H-chromene skeleton were prepared by reacting the monoterpenoid para-mentha-1,8-diene-5,6-diol with…”
Get full text

Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties by Ponomarev, K. Yu, Morozova, E. A., Suslov, E. V., Korchagina, D. V., Tolstikova, T. G., Volcho, K. P., Salakhutdinov, N. F.

“…A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted…”
Get full text

Derivatives of usnic acid inhibit broad range of influenza viruses and protect mice from lethal influenza infection by Shtro, AA, Zarubaev, VV, Luzina, OA, Sokolov, DN, Salakhutdinov, NF

“…Background Influenza is a disease of significant morbidity and mortality, the number of anti-influenza drugs is small; many of them stimulate the appearance of…”
Get full text

Hypercholesterolemia: chemical aspect of approach by Salakhutdinov, N F, Rogoza, L N, Tolstikov, G A

“…This review is the first attempt at systematization and analysis of the literature data (covering the last decade) on the chemical structures and specific…”
Get more information

Diquaternized curarelike myorelaxants: structure and biological activity by Salakhutdinov, N F, Tolstikov, G A

“…This review discusses the most active natural and synthetic curarelike compounds demonstrating myorelaxants activity. The data are grouped according to…”
Get more information

Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents by Pavlova, A. V., Nazimova, E. V., Mikhal’chenko, O. S., Il’ina, I. V., Korchagina, D. V., Ardashov, O. V., Morozova, E. A., Tolstikova, T. G., Volcho, K. P., Salakhutdinov, N. F.

“…Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane monoterpenoid diol with several thiophenecarboxaldehydes. Most…”
Get full text

Whether Molecular Dynamics Methods Can Explain Different Activities of Stereoisomers Against Respiratory Syncytial Virus or Not? by Borisevich, S. S., Volcho, K. P., Salakhutdinov, N. F.

“…The antiviral activity of monoterpene-aryl coumarin conjugates depends on the absolute configuration of the monoterpene moiety, which seems to be due to…”
Get full text

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models by Zakharenko, A.L., Luzina, O.A., Sokolov, D.N., Kaledin, V.I., Nikolin, V.P., Popova, N.A., Patel, J., Zakharova, O.D., Chepanova, A.A., Zafar, A., Reynisson, J., Leung, E., Leung, I.K.H., Volcho, K.P., Salakhutdinov, N.F., Lavrik, O.I.

“…The druggability of the tyrosyl-DNA phosphodiesterase 1 (Tdp1) enzyme was investigated in conjunction with topoisomerase 1 inhibition. A novel class of…”
Get full text

Clays catalyzed cascade Prins and Prins-Friedel-Crafts reactions for synthesis of terpenoid-derived polycyclic compounds by Sidorenko, A.Yu, Kurban, Yu.M., Kravtsova, A.V., Il'ina, I.V., Li-Zhulanov, N.S., Korchagina, D.V., Sánchez-Velandia, J.E., Aho, A., Volcho, K.P., Salakhutdinov, N.F., Murzin, D.Yu, Agabekov, V.E.

“…The Prins/Friedel-Crafts cascade reactions of the terpenoid trans-4-hydroxymethyl-2-carene (synthesized from 3-carene) with aromatic aldehydes were…”
Get full text

Biological activity of usnic acid and its derivatives: Part 2. effects on higher organisms. Molecular and physicochemical aspects by Luzina, O. A., Salakhutdinov, N. F.

“…Usnic acid (UA) is a commercially available lichen metabolite. Its biological activity is diverse, and it is of interest for pharmacopoeia. The second part of…”
Get full text

3-Oxabicyclo[3.3.1]nonenes: synthesis and investigation as tyrosyl-DNA phosphodiesterase 1 inhibitors by Dyrkheeva, N. S., Ilyina, I. V., Volcho, K. P., Salakhutdinov, N. F., Lavrik, O. I.

“…Compounds with a 3-oxabicyclo[3.3.1]nonane core were prepared from limonene and aromatic aldehydes containing methoxy groups and phthalaldehydes in the…”
Get full text

Biological activity of usnic acid and its derivatives: Part 1. Activity against unicellular organisms by Luzina, O. A., Salakhutdinov, N. F.

“…Usnic acid (UA) is a commercially available lichen metabolite. Its biological activity is diverse. Its broad occurrence in various lichen species, simple…”
Get full text

Synthesis and evaluation of camphor and cytisine-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus by Kuranov, S.O., Tsypysheva, I.P., Khvostov, M.V., Zainullina, Liana F., Borisevich, S.S., Vakhitova, Yu.V., Luzina, O.A., Salakhutdinov, N.F.

“…[Display omitted] In this study, bornyl- and cytisine-based cyanopyrrolidines as potent dipeptidyl peptidase-IV (DPP-IV) inhibitors were synthesised. The in…”
Get full text

New derivatives of dehydroabiethylamine and adamantane: synthesis and activity as inhibitors of the repair enzyme TDP1 by Kovaleva, K. S., Yarovaya, O. I., Chernyshova, I. A., Lavrik, O. I., Salakhutdinov, N. F.

“…A number of new conjugates of dehydroabiethylamine and adamantane was obtained using a three-step synthetic scheme in order to study the effect of linker type…”
Get full text