Distribution of quinolone resistance gene ( qnr ) in ESBL- producing Escherichia coli and Klebsiella spp. in Lomé, Togo

Distribution of quinolone resistance gene ( qnr ) in ESBL- producing Escherichia coli and Klebsiella spp. in Lomé, Togo

genes are known to confer a low-level resistance to fluoroquinolone in . They are often found on the same resistance plasmids as extended spectrum β-lactamase (ESBL) and constitute the most common antibiotic resistance mechanism. This study aimed to detect the presence of r genes in -producing and ....

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Bibliographic Details
Published in:Antimicrobial resistance & infection control Vol. 8; no. 1; p. 104
Main Authors: Salah, Fortune Djimabi, Soubeiga, Serge Théophile, Ouattara, Abdoul Karim, Sadji, Adodo Yao, Metuor-Dabire, Amana, Obiri-Yeboah, Dorcas, Banla-Kere, Abiba, Karou, Simplice, Simpore, Jacques
Format: Journal Article
Language:English
Published: England BioMed Central 18-06-2019
BMC
Subjects:
Annealing
Antibiotic resistance
Antibiotics
Deoxyribonucleic acid
Disease control
DNA
Drug resistance
E coli
ESBL
Genes
Genetic testing
Identification systems
Klebsiella spp
Laboratories
Plasmids
Qnr gene
Thermal cycling
Togo
Urogenital system
Algeria
Togo
France
United States > US
ESBL
Qnr gene
Togo
E. coli
Klebsiella spp
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Summary:genes are known to confer a low-level resistance to fluoroquinolone in . They are often found on the same resistance plasmids as extended spectrum β-lactamase (ESBL) and constitute the most common antibiotic resistance mechanism. This study aimed to detect the presence of r genes in -producing and . From May 2013 to July 2015, 91 and 64 strains with phenotypic resistance to quinolone were collected from several specimens and analyzed for the detection of genes and the β-lactamase resistance genes ( , , ) using simplex and multiplex PCR. In the present study, 107 (69%; 61 and 46 ) of 155 bacterial strains tested were found harboring at least one gene consisting of 74 (47.74%) , 73 (47.10%) and 4 (2.58%) . Of the 107 strains encoding genes, 102, 96 and 52 carried , and type ESBL respectively. This study identified quinolone resistance ( ) gene in -producing and in Togo. These finding which suggest a possible resistance to quinolone are of high interest for better management of patients and control of antimicrobial resistance in Togo.
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ISSN:2047-2994
2047-2994
DOI:10.1186/s13756-019-0552-0