Search Results - "Salaga, M"

Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis by Salaga, M, Binienda, A, Draczkowski, P, Kosson, P, Kordek, R, Jozwiak, K, Fichna, J

“…[Display omitted] •Protease inhibition is a new approach in the inflammatory bowel disease therapy.•Dipeptidyl peptidase IV is a pharmacological target for…”
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Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome by Sałaga, M, Polepally, P R, Sobczak, M, Grzywacz, D, Kamysz, W, Sibaev, A, Storr, M, Do Rego, J C, Zjawiony, J K, Fichna, J

“…The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid…”
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Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid‐like fatty acid amides by Fichna, J., Sałaga, M., Stuart, J., Saur, D., Sobczak, M., Zatorski, H., Timmermans, J. ‐P., Bradshaw, H. B., Ahn, K., Storr, M. A.

“…Background The endogenous cannabinoid system (ECS) plays a crucial role in multiple physiological processes in the central nervous system and in the periphery…”
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Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH) by Sałaga, M., Mokrowiecka, A., Zakrzewski, P.K., Cygankiewicz, A., Leishman, E., Sobczak, M., Zatorski, H., Małecka-Panas, E., Kordek, R., Storr, M., Krajewska, W.M., Bradshaw, H.B., Fichna, J.

“…Pharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBD) is currently one of the biggest challenge in the field of…”
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Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice by Salaga, M, Blomster, L V, Piechota-Polańczyk, A, Zielińska, M, Jacenik, D, Cygankiewicz, A I, Krajewska, W M, Mikkelsen, J D, Fichna, Jakub

“…The α7 pentamer nicotinic acetylcholine receptors (nAChRs) are a target in transduction of anti-inflammatory signals from the central nervous system to the…”
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FABP4 blocker attenuates colonic hypomotility and modulates white adipose tissue‐derived hormone levels in mouse models mimicking constipation‐predominant IBS by Mosińska, P., Jacenik, D., Sałaga, M., Wasilewski, A., Cygankiewicz, A., Sibaev, A., Mokrowiecka, A., Małecka‐Panas, E., Pintelon, I., Storr, M., Timmermans, J. P., Krajewska, W. M., Fichna, J.

“…Background The role of fatty acid binding protein 4 (FABP4) in lower gastrointestinal (GI) motility is unknown. We aimed to verify the effect of inhibition of…”
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Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea‐predominant IBS by Fichna, J., Sobczak, M., Mokrowiecka, A., Cygankiewicz, A. I., Zakrzewski, P. K., Cenac, N., Sałaga, M., Timmermans, J.‐P., Vergnolle, N., Małecka‐Panas, E., Krajewska, W. M., Storr, M.

“…Background Diarrhea‐predominant irritable bowel syndrome (IBS‐D) is a functional gastrointestinal (GI) disorder, defined by the presence of loose stools and…”
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Highly selective CB2 receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice by Salaga, M., Zatorski, H., Zielińska, M., Mosinska, P., Timmermans, J-P., Kordek, R., Storr, M., Fichna, J.

“…Cannabinoid type 2 (CB 2 ) receptors are distributed in central and peripheral tissues, including immunocytes and the gastrointestinal (GI) tract, suggesting…”
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Salvinorin A analogues PR‐37 and PR‐38 attenuate compound 48/80‐induced itch responses in mice by Salaga, M, Polepally, P R, Zielinska, M, Marynowski, M, Fabisiak, A, Murawska, N, Sobczak, K, Sacharczuk, M, Do Rego, J C, Roth, B L, Zjawiony, J K, Fichna, J

“…Background and Purpose The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that…”
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The cannabinoid‐1 receptor inverse agonist taranabant reduces abdominal pain and increases intestinal transit in mice by Fichna, J., Sibaev, A., Sałaga, M., Sobczak, M., Storr, M.

“…Background Constipation‐predominant irritable bowel syndrome (IBS‐C) is a common functional gastrointestinal (GI) disorder with abdominal pain and decreased…”
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Systemic Administration of Sialorphin Attenuates Experimental Colitis in Mice via Interaction With Mu and Kappa Opioid Receptors by Salaga, M, Mokrowiecka, A, Jacenik, D, Cygankiewicz, A I, Malecka-Panas, E, Kordek, R, Krajewska, W M, Sobocinska, M K, Kamysz, E, Fichna, J

“…Pharmacological treatment and/or maintenance of remission in inflammatory bowel disease [IBD] is currently one of the biggest challenges in the field of…”
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Polyphenol extract from evening primrose pomace alleviates experimental colitis after intracolonic and oral administration in mice by Sałaga, M., Lewandowska, U., Sosnowska, D., Zakrzewski, P. K., Cygankiewicz, A. I., Piechota-Polańczyk, A., Sobczak, M., Mosinska, P., Chen, Chunqiu, Krajewska, W. M., Fichna, J.

“…Oenothera paradoxa (EP) preparations are commonly used in folk medicine to treat skin diseases, neuralgia, and gastrointestinal (GI) disorders. Several reports…”
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Calea zacatechichi dichloromethane extract exhibits antidiarrheal and antinociceptive effects in mouse models mimicking irritable bowel syndrome by Sałaga, M., Kowalczuk, A., Zielinska, M., Błażewicz, A., Fichna, J.

“…Calea zacatechichi Schltdl. (Asteraceae alt. Compositae) is a Mexican plant commonly used in folk medicine to treat respiratory and gastrointestinal (GI)…”
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Focus on current and future management possibilities in inflammatory bowel disease-related chronic pain by Zielińska, Anna, Sałaga, Maciej, Włodarczyk, Marcin, Fichna, Jakub

“…Introduction Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this…”
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High activity of endogenous opioid system protects against gastric damage development in mouse models of gastric mucosal injury by Zatorski, Hubert, Salaga, Maciej, Zielińska, Marta, Wasilewski, Andrzej, Misicka, Aleksandra, Sacharczuk, Mariusz, Fichna, Jakub

“…Gastric mucosal injury appears when acid and pepsin production, simultaneously with inadequate mucosal response, overwhelms protective mechanism in stomach…”
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Highly selective CB^sub 2^ receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice by Salaga, M, Zatorski, H, Zielińska, M, Mosinska, P, Timmermans, J-p, Kordek, R, Storr, M, Fichna, J

“…Cannabinoid type 2 (CB2) receptors are distributed in central and peripheral tissues, including immunocytes and the gastrointestinal (GI) tract, suggesting…”
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Anti-inflammatory and antinociceptive action of an orally available nociceptin receptor agonist SCH 221510 in a mouse model of inflammatory bowel diseases by Sobczak, Marta, Mokrowiecka, Anna, Cygankiewicz, Adam I, Zakrzewski, Piotr K, Sałaga, Maciej, Storr, Martin, Kordek, Radzisław, Małecka-Panas, Ewa, Krajewska, Wanda M, Fichna, Jakub

“…The nociceptin receptors (NOPs) are expressed in the gastrointestinal (GI) tract on muscle cell membranes and neurons, as well as the immune cells that…”
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Nociceptin / orphanin FQ (NOP) receptors as novel potential target in the treatment of gastrointestinal diseases by Sobczak, Marta, Sałaga, Maciej, Storr, Martin, Fichna, Jakub

“…The nociceptin system, which consists of endogenous nociceptin/orphanin FQ and NOP receptors, is present in the central nervous system (CNS), as well as…”
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Orally administered novel cyclic pentapeptide P-317 alleviates symptoms of diarrhoea-predominant irritable bowel syndrome by Zielińska, Marta, Chen, Chunqiu, Mokrowiecka, Anna, Cygankiewicz, Adam I., Zakrzewski, Piotr K., Sałaga, Maciej, Małecka-Panas, Ewa, Wlaź, Piotr, Krajewska, Wanda M., Fichna, Jakub

“…Objective The aim of our study was to characterize the effect of P‐317, a novel cyclic derivative of morphiceptin, on gastrointestinal (GI) motility and…”
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Young gastroenterologists angle: Friends of the UEG young talent group consensus statement on the structure of young gastroenterology sections by Staudacher, Jonas Jaromir, Burisch, Johan, Sousa, Paula, Salaga, Maciej, Pellino, Gianluca, Sidiropoulos, Orestis, Groen, Maarten te, Mandorfer, Mattias, Schwabl, Philipp, Straume, Zane, Bîrlog, Clarisa, Dugic, Ana, Simsek, Cem, Jovanovic, Jelena, Kani, Haluk Tarik, Qejvani, Odri, Fennessy, Anne M., Gorcheva, Zornica, Kral, Jan, Zanetto, Alberto, Duricek, Martin, Domislovic, Viktor, Acedo, Pilar, Schlosser, Sophie

“…In our eyes, a durable and practical structure is fundamental to long-term effective cooperation and success. [...]we present a consensus on a possible…”
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