Search Results - "Saku, Osamu"

K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund’s Adjuvant Model by Sugimoto, Yoshiyuki, Kojima, Yozo, Inayoshi, Atsushi, Inoue, Kazuaki, Miura-Kusaka, Hiroko, Mori, Kiyotoshi, Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Nakasato, Yoshisuke, Shirakura, Shiro, Toki, Shin-ichiro, Shinoda, Katsumi, Suzuki, Nobuyuki

“…Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple…”
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Synthesis of 1-Azaazulenes from Cycloheptatrienylmethyl Ketone O-Pentafluorobenzoyloximes by Palladium-Catalyzed Cyclization and Oxidation by Chiba, Shunsuke, Kitamura, Mitsuru, Saku, Osamu, Narasaka, Koichi

“…Various 1-azaazulenes are synthesized from cycloheptatrienylmethyl ketone O-pentafluorobenzoyloximes by treatment with a catalytic amount of Pd(dba)2–t-Bu3P…”
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Palladium-Catalyzed Synthesis of 1-Azaazulenes from Cycloheptatrienylmethyl Ketone O-Pentafluorobenzoyl Oximes by Kitamura, Mitsuru, Chiba, Shunsuke, Saku, Osamu, Narasaka, Koichi

“…Substituted 1-azaazulenes are synthesized from cycloheptatrienylmethyl ketone O-pentafluorobenzoyloximes by the intramolecular Heck-type amination catalyzed by…”
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Synthetic studies on selective adenosine A2A receptor antagonists: Synthesis and structure-activity relationships of novel benzofuran derivatives by SAKU, Osamu, SAKI, Mayumi, KUROKAWA, Masako, IKEDA, Ken, TAKIZAWA, Takuya, UESAKA, Noriaki

“…A series of benzofuran derivatives were prepared to study their antagonistic activities to the A(2A) receptor. Replacement of the ester group of the lead…”
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Discovery of Novel 5,5-Diarylpentadienamides as Orally Available Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists by Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Sugimoto, Yoshiyuki, Kodaira, Hiroshi, Kato, Yoshimitsu, Shirakura, Shiro, Nakasato, Yoshisuke

“…We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we…”
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Synthetic studies on selective adenosine A2A receptor antagonists. Part II: Synthesis and structure–activity relationships of novel benzofuran derivatives by Saku, Osamu, Saki, Mayumi, Kurokawa, Masako, Ikeda, Ken, Uchida, Shin-ichi, Takizawa, Takuya, Uesaka, Noriaki

“…The discovery of a novel series of A2A antagonists is described. A selected compound was shown to be able to induce anti-parkinsonian effects in MPTP-treated…”
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Synthetic study of VLA-4/VCAM-1 inhibitors: Synthesis and structure–activity relationship of piperazinylphenylalanine derivatives by Saku, Osamu, Ohta, Kiminori, Arai, Eri, Nomoto, Yuji, Miura, Hiroko, Nakamura, Hiroaki, Fuse, Eiichi, Nakasato, Yoshisuke

“…To improve poor pharmacokinetic characters of the preceding VLA-4 inhibitors, novel piperazinylphenylalanine derivatives were designed and optimized for oral…”
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Synthetic studies on selective adenosine A sub(2A) receptor antagonists: Synthesis and structure-activity relationships of novel benzofuran derivatives by Saku, Osamu, Saki, Mayumi, Kurokawa, Masako, Ikeda, Ken, Takizawa, Takuya, Uesaka, Noriaki

“…A series of benzofuran derivatives were prepared to study their antagonistic activities to the A sub(2A) receptor. Replacement of the ester group of the lead…”
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Synthetic studies on selective adenosine A 2A receptor antagonists: Synthesis and structure–activity relationships of novel benzofuran derivatives by Saku, Osamu, Saki, Mayumi, Kurokawa, Masako, Ikeda, Ken, Takizawa, Takuya, Uesaka, Noriaki

“…Novel benzofuran derivatives as potent and selective adenosine A 2A inhibitors were synthesized and evaluated. A series of benzofuran derivatives were prepared…”
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Synthesis of indole and indolenine derivatives starting from indoline-2-thiones by Nishio, Takehiko, Saku, Osamu, Yamamoto, Hiroshi

“…Indoline‐2‐thiones 1a‐b,d,f,h, which have at least one hydrogen at the 3‐position reacted with α‐halo ester 2a‐d, α‐halo ketones 2e‐f, and a‐bromoacetonitrile…”
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