Search Results - "Sakthivel, Dharaniya"

Noninvasive Flap Preconditioning by Foam-Mediated External Suction Improves the Survival of Fasciocutaneous Axial-Pattern Flaps in a Type 2 Diabetic Murine Model by Rhodius, Patrick, Haddad, Anthony, Matsumine, Hajime, Sakthivel, Dharaniya, Ackermann, Maximilian, Sinha, Indranil, Orgill, Dennis P., Giatsidis, Giorgio

“…BACKGROUND:Advances in reconstructive surgery are leading to an increased number of flaps at risk for ischemic necrosis, because of either intrinsic (e.g.,…”
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Systemic Regulators of Skeletal Muscle Regeneration in Obesity by Sinha, Indranil, Sakthivel, Dharaniya, Varon, David E

“…Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in…”
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Homozygous Mutation in the MTHFS Gene May Contribute to the Development of Cerebral Folate Deficiency Syndrome by Sakthivel, Dharaniya, Lei, Yunping, Cao, Xuanye, Finnell, Richard H.

“…Objective: The purpose of this study was to examine the role of rare variants in the one-carbon metabolic pathway in the etiology of the cerebral folate…”
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Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity by Sinha, Indranil, Sakthivel, Dharaniya, Olenchock, Benjamin A, Kruse, Carla R, Williams, Jeremy, Varon, David E, Smith, Jessica D, Madenci, Arin L, Nuutila, Kristo, Wagers, Amy J

“…Obesity leads to a loss of muscle mass and impaired muscle regeneration. In obese individuals, pathologically elevated levels of prolyl hydroxylase domain…”
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Cellular autophagy, an unbidden effect of caspase inhibition by zVAD‐fmk by Sakthivel, Dharaniya, Bolívar, Beatriz E., Bouchier‐Hayes, Lisa

“…zVAD‐fmk is a widely used pan‐caspase inhibitor that blocks apoptosis but has undesirable side effects, including autophagy. In this issue, Needs et al…”
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Age-Related Dysregulation of Hypoxia Signaling Limits Skeletal Muscle Regeneration in Aging by Endo, Yori, Baldino, Kodi, Li, Bin, Zhang, Yuteng, Sakthivel, Dharaniya, Panayi, Adriana C., Sinha, Indranil

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Abstract 2397: Significance of the combination of biguanides and fatty acid β-oxidation inhibitors in triple-negative breast cancer by Park, Junhyoung, Jung, Kwang Hwa, Jia, Dongya, Yang, Sukjin, Sakthivel, Dharaniya, Tiwari, Abha, Onuchic, José N., Kaipparettu, Benny Abraham

“…Compared to hormone receptor (HR) positive breast cancer (BC), basal or triple-negative BC (TNBC) suffers a poor prognosis, attributed to the limited…”
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The role of the nucleolus in regulating the cell cycle and the DNA damage response by Sakthivel, Dharaniya, Brown-Suedel, Alexandra, Bouchier-Hayes, Lisa

“…The nucleolus has long been perceived as the site for ribosome biogenesis, but numerous studies suggest that the nucleolus carefully sequesters crucial…”
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Noninvasive Skin Preconditioning by Micro Deformational External Suction Improves Skin Vascularity and Reduces Surgical Complications after Reconstructive Surgeries in an Obesity Induced Diabetic Murine Model by Giatsidis, Giorgio, Haddad, Anthony, Rhodius, Patrick, Matsumine, Hajime, Sakthivel, Dharaniya, Sinha, Indranil, Orgill, Dennis P.

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A porous collagen‐GAG scaffold promotes muscle regeneration following volumetric muscle loss injury by Panayi, Adriana C., Smit, Lucindi, Hays, Nicole, Udeh, Kodi, Endo, Yori, Li, Bin, Sakthivel, Dharaniya, Tamayol, Ali, Neppl, Ronald L., Orgill, Dennis P., Nuutila, Kristo, Sinha, Indranil

“…Volumetric muscle loss (VML) is a segmental loss of skeletal muscle which commonly heals with fibrosis, minimal muscle regeneration, and loss of muscle…”
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Loss of ARNT in skeletal muscle limits muscle regeneration in aging by Endo, Yori, Baldino, Kodi, Li, Bin, Zhang, Yuteng, Sakthivel, Dharaniya, MacArthur, Michael, Panayi, Adriana C., Kip, Peter, Spencer, Daniel J., Jasuja, Ravi, Bagchi, Debalina, Bhasin, Shalender, Nuutila, Kristo, Neppl, Ronald L., Wagers, Amy J., Sinha, Indranil

“…The ability of skeletal muscle to regenerate declines significantly with aging. The expression of aryl hydrocarbon receptor nuclear translocator (ARNT), a…”
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Gene expression profiling of skeletal muscle after volumetric muscle loss by Nuutila, Kristo, Sakthivel, Dharaniya, Kruse, Carla, Tran, Peter, Giatsidis, Giorgio, Sinha, Indranil

“…Volumetric muscle loss (VML), usually occurring following traumatic injury, results in a composite loss of muscle mass. These injuries manifest as decreased…”
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Reduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage by Krezdorn, Nicco, Sakthivel, Dharaniya, Turk, Marvee, Aycart, Mario A., Tasigiorgos, Sotirios, Bueno, Ericka M., Sinha, Indranil, Pomahac, Bohdan

“…Ischemia-reperfusion injury remains the major limiting factor for limb replantation and transplantation. Static cold storage (SCS) on ice currently represents…”
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Evaluation of the efficacy of cell and micrograft transplantation for full-thickness wound healing by Kruse, Carla R., Sakthivel, Dharaniya, Sinha, Indranil, Helm, Douglas, Sørensen, Jens A., Eriksson, Elof, Nuutila, Kristo

“…Skin grafting is the current standard of care in the treatment of full-thickness burns and other wounds. It is sometimes associated with substantial problems,…”
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Abstract LB035: The role of nucleophosmin1 mediated caspase2 activation in acute myeloid leukemia cell death and cell survival by Sakthivel, Dharaniya, Brown-Suedel, Alexandra, Keane, Francesca, McSherry, F. Kenneth, Charendoff, Chloe I., Dunne, Kevin, Robichaux, Dexter, Flanagan, Jonathan M., Bouchier-Hayes, Lisa

“…Nucleophosmin 1 (NPM1) mutation is the primary genetic lesion in adult acute myeloid leukemia (AML). Typically, a nucleolar protein, NPM1 mutations cause…”
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RESTORATION OF HYPOXIA SIGNALING IMPROVES AGING-ASSOCIATED LOSS OF SKELETAL MUSCLE REGENERATIVE POTENTIAL by Udeh, Kodi, Li, Bin, Endo, Yori, Panayi, Adriana, Sakthivel, Dharaniya, Neppl, Ron, Wagers, Amy, Sinha, Idranil

“…Skeletal muscle retains the ability to regenerate throughout life, but this decreases significantly with aging. The present study investigates whether…”
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Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia by Sakthivel, Dharaniya, Brown-Suedel, Alexandra N, Lopez, Karla E, Salgar, Suruchi, Coutinho, Luiza E, Keane, Francesca, Huang, Shixia, Sherry, Kenneth Mc, Charendoff, Chloé I, Dunne, Kevin P, Robichaux, Dexter J, Vargas-Hernández, Alexander, Le, BaoChau, Shin, Crystal S, Carisey, Alexandre F, Poreba, Marcin, Flanagan, Jonathan M, Bouchier-Hayes, Lisa

“…Mutation in nucleophosmin (NPM1) causes relocalization of this normally nucleolar protein to the cytoplasm (NPM1c+). Despite NPM1 mutation being the most…”
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Use of a novel chitosan-based dressing on split-thickness skin graft donor sites: a pilot study by Varon, David E., Smith, Jessica D., Bharadia, Deepak R., Shafique, Neha, Sakthivel, Dharaniya, Halvorson, Eric G., Nuutila, Kristo, Sinha, Indranil

“…Objective: Split-thickness skin graft (STSG) donor site dressings can play an integral role in reducing donor site morbidity. This study tested a novel,…”
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Development of an inducible system for expression of proteins in diffuse large B cell lymphoma by Sakthivel, Dharaniya

“…Diffuse large B cell lymphoma (DLBCL) is a heterogeneous malignancy distinguished by aggressive clinical symptoms and abnormal B cell receptor signaling…”
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