Search Results - "Saksouk, Nehmé"

Constitutive heterochromatin formation and transcription in mammals by Saksouk, Nehmé, Simboeck, Elisabeth, Déjardin, Jérôme

“…Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is believed to ensure a condensed and transcriptionally inert…”
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Role for miR-204 in human pulmonary arterial hypertension by Courboulin, Audrey, Paulin, Roxane, Giguère, Nellie J, Saksouk, Nehmé, Perreault, Tanya, Meloche, Jolyane, Paquet, Eric R, Biardel, Sabrina, Provencher, Steeve, Côté, Jacques, Simard, Martin J, Bonnet, Sébastien

“…Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs)…”
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Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency by van Mierlo, Guido, Dirks, René A.M., De Clerck, Laura, Brinkman, Arie B., Huth, Michelle, Kloet, Susan L., Saksouk, Nehmé, Kroeze, Leonie I., Willems, Sander, Farlik, Matthias, Bock, Christoph, Jansen, Joop H., Deforce, Dieter, Vermeulen, Michiel, Déjardin, Jérôme, Dhaenens, Maarten, Marks, Hendrik

“…The pluripotent ground state is defined as a basal state free of epigenetic restrictions, which influence lineage specification. While naive embryonic stem…”
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Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation by Saksouk, Nehmé, Barth, Teresa K., Ziegler-Birling, Celine, Olova, Nelly, Nowak, Agnieszka, Rey, Elodie, Mateos-Langerak, Julio, Urbach, Serge, Reik, Wolf, Torres-Padilla, Maria-Elena, Imhof, Axel, Déjardin, Jérome

“…Constitutive heterochromatin is typically defined by high levels of DNA methylation and H3 lysine 9 trimethylation (H3K9Me3), whereas facultative…”
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Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension by Paulin, Roxane, Courboulin, Audrey, Meloche, Jolyane, Mainguy, Vincent, Dumas de la Roque, Eric, Saksouk, Nehmé, Côté, Jacques, Provencher, Steeve, Sussman, Mark A, Bonnet, Sébastien

“…Pulmonary artery hypertension (PAH) is a proliferative disorder associated with enhanced pulmonary artery smooth muscle cell proliferation and suppressed…”
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Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity by Lalonde, Marie-Eve, Avvakumov, Nikita, Glass, Karen C, Joncas, France-Hélène, Saksouk, Nehmé, Holliday, Michael, Paquet, Eric, Yan, Kezhi, Tong, Qiong, Klein, Brianna J, Tan, Song, Yang, Xiang-Jiao, Kutateladze, Tatiana G, Côté, Jacques

“…Histone acetyltransferases (HATs) assemble into multisubunit complexes in order to target distinct lysine residues on nucleosomal histones. Here, we…”
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The mouse HP1 proteins are essential for preventing liver tumorigenesis by Saksouk, Nehmé, Hajdari, Shefqet, Perez, Yannick, Pratlong, Marine, Barrachina, Célia, Graber, Céline, Grégoire, Damien, Zavoriti, Aliki, Sarrazin, Amélie, Pirot, Nelly, Noël, Jean-Yohan, Khellaf, Lakhdar, Fabbrizio, Eric, Julien, Eric, Cammas, Florence M.

“…Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin-associated proteins HP1…”
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Guiding the HBO1 complex function through the JADE subunit by Gaurav, Nitika, Kanai, Akinori, Lachance, Catherine, Cox, Khan L., Liu, Jiuyang, Grzybowski, Adrian T., Saksouk, Nehmé, Klein, Brianna J., Komata, Yosuke, Asada, Shuhei, Ruthenburg, Alexander J., Poirier, Michael G., Côté, Jacques, Yokoyama, Akihiko, Kutateladze, Tatiana G.

“…JADE is a core subunit of the HBO1 acetyltransferase complex that regulates developmental and epigenetic programs and promotes gene transcription. Here we…”
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SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres by Gauchier, Mathilde, Kan, Sophie, Barral, Amandine, Sauzet, Sandrine, Agirre, Eneritz, Bonnell, Erin, Saksouk, Nehmé, Barth, Teresa K, Ide, Satoru, Urbach, Serge, Wellinger, Raymund J, Luco, Reini F, Imhof, Axel, Déjardin, Jérôme

“…Alternative lengthening of telomeres, or ALT, is a recombination-based process that maintains telomeres to render some cancer cells immortal. The prevailing…”
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Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation by Avvakumov, Nikita, Lalonde, Marie-Eve, Saksouk, Nehmé, Paquet, Eric, Glass, Karen C., Landry, Anne-Julie, Doyon, Yannick, Cayrou, Christelle, Robitaille, Geneviève A., Richard, Darren E., Yang, Xiang-Jiao, Kutateladze, Tatiana G., Côté, Jacques

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Histone modifications in response to DNA damage by Altaf, Mohammed, Saksouk, Nehmé, Côté, Jacques

“…The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication,…”
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HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail by Saksouk, Nehmé, Avvakumov, Nikita, Champagne, Karen S., Hung, Tiffany, Doyon, Yannick, Cayrou, Christelle, Paquet, Eric, Ullah, Mukta, Landry, Anne-Julie, Côté, Valérie, Yang, Xiang-Jiao, Gozani, Or, Kutateladze, Tatiana G., Côté, Jacques

“…The HBO1 HAT protein is the major source of histone H4 acetylation in vivo and has been shown to play critical roles in gene regulation and DNA replication. A…”
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Proteome Characterization of a Chromatin Locus Using the Proteomics of Isolated Chromatin Segments Approach by Kan, Sophie L, Saksouk, Nehmé, Déjardin, Jérome

“…The biological functions of given genomic regions are ruled by the local chromatin composition. The Proteomics of Isolated Chromatin segments approach (PICh)…”
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Histone-Modifying Complexes Regulate Gene Expression Pertinent to the Differentiation of the Protozoan Parasite Toxoplasma gondii by Saksouk, Nehmé, Bhatti, Micah M, Kieffer, Sylvie, Smith, Aaron T, Musset, Karine, Garin, Jérôme, Sullivan, Jr, William J, Cesbron-Delauw, Marie-France, Hakimi, Mohamed-Ali

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Endogenous Retroviral Sequences Behave as Putative Enhancers Controlling Gene Expression through HP1-Regulated Long-Range Chromatin Interactions by Calvet, Sébastien, Sallis, Séphora, Saksouk, Nehmé, Rebouissou, Cosette, Teyssier, Catherine, Lesne, Annick, Cammas, Florence, Forné, Thierry

“…About half of the mammalian genome is constituted of repeated elements, among which endogenous retroviruses (ERVs) are known to influence gene expression and…”
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The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide by Champagne, Karen S., Saksouk, Nehmé, Peña, Pedro V., Johnson, Kyle, Ullah, Mukta, Yang, Xiang-Jiao, Côté, Jacques, Kutateladze, Tatiana G.

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Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation by Saksouk, Nehmé, Barth, Teresa K., Ziegler-Birling, Celine, Olova, Nelly, Nowak, Agnieszka, Rey, Elodie, Simboeck, Elisabeth, Mateos-Langerak, Julio, Urbach, Serge, Reik, Wolf, Torres-Padilla, Maria-Elena, Imhof, Axel, Déjardin, Jérome

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histone methylase KMTox interacts with the redox-sensor peroxiredoxin-1 and targets genes involved in Toxoplasma gondii antioxidant defences by Sautel, Céline F, Ortet, Philippe, Saksouk, Nehmé, Kieffer, Sylvie, Garin, Jérôme, Bastien, Olivier, Hakimi, Mohamed-Ali

“…The ability of living cells to alter their gene expression patterns in response to environmental changes is essential for viability. Oxidative stress…”
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A Toxoplasma type 2C serine-threonine phosphatase is involved in parasite growth in the mammalian host cell by Jan, Gaelle, Delorme, Violaine, Saksouk, Nehmé, Abrivard, Marie, Gonzalez, Virginie, Cayla, Xavier, Hakimi, Mohamed-Ali, Tardieux, Isabelle

“…Toxoplasma gondii is a human protozoan parasite that belongs to the phylum of Apicomplexa and causes toxoplasmosis. As the other members of this phylum, T…”
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The glucosyl-1-phosphate transferase WchA (Cap8E) primes the capsular polysaccharide repeat unit biosynthesis of Streptococcus pneumoniae serotype 8 by Pelosi, Ludovic, Boumedienne, Manel, Saksouk, Nehmé, Geiselmann, Johannes, Geremia, Roberto A.

“…The gene wchA ( cap8E) belongs to the cps8 locus that is involved in biosynthesis of the capsular polysaccharide (CPS) repeat unit (RU) of the virulent…”
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