Search Results - "Saksela, Eero"

The Predictive Value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for Chemotherapy Response in Advanced Breast Cancer by SJÖSTRÖM, Johanna, BLOMQVIST, Carl, REED, John C, SAKSELA, Eero, VON BOGUSLAWSKI, Kristina, BENGTSSON, Nils-Olof, MJAALAND, Ingvil, MALMSTRÖM, Per, OSTENSTADT, Björn, WIST, Erik, VALVERE, Vahur, TAKAYAMA, Shinichi

“…Purpose: The purpose was to evaluate the utility of some bcl-2 family proteins fas and fasL as predictive indicators for chemotherapy response in advanced…”
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Predictive Value of p53, mdm-2, p21, and mib-1 for Chemotherapy Response in Advanced Breast Cancer by SJÖSTRÖM, J, BLOMQVIST, C, WIST, E, VALVERE, V, SAKSELA, E, HEIKKILÄ, P, VON BOGUSLAWSKI, K, RÄISÄNEN-SOKOLOWSKI, A, BENGTSSON, N.-O, MJAALAND, I, MALMSTRÖM, P, OSTENSTADT, B, BERGH, J

“…p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. The protein product of the murine double minute gene 2…”
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Activation of Natural Killer Cell Migration by Leukocyte Integrin-binding Peptide from Intracellular Adhesion Molecule-2 (ICAM-2) by Somersalo, Kristina, Carpén, Olli, Saksela, Eero, Gahmberg, Carl G., Nortamo, Pekka, Timonen, Tuomo

“…Intracellular adhesion molecule-2 (ICAM-2), one of the ligands of CD11a/CD18 (LFA-1), is mainly expressed on endothelial and hematopoietic cells. The…”
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c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors by KLEFSTROM, J, KOVANEN, P. E, SOMERSALO, K, HUEBER, A.-O, LITTLEWOOD, T, EVAN, G. I, GREENBERG, A. H, SAKSELA, E, TIMONEN, T, ALITALO, K

“…The contact of natural killer (NK) cells with foreign cells and with certain virus-infected or tumor cells triggers the cytolytic machinery of NK cells. This…”
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Analysis of collagen isotypes in crystalloid structures of salivary gland tumors by Skalova, A, Leivo, I, Michal, M, Saksela, E

“…Extracellular collagenous crystalloids (CCs) have been reported in salivary gland tumors. To study the occurrence and characteristics of these structures we…”
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Are "natural killer" cells involved in allograft rejection? by Nemlander, A, Saksela, E, Häyry, P

“…"Natural killer" (NK) effector cells and large granular lymphocytes (LGL) are found inside rat renal allografts during rejection. Their appearance in situ…”
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The cytotoxic activity of human natural killer cells requires an intact secretory apparatus by Carpén, O, Virtanen, I, Saksela, E

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TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer by Villman, Kenneth, Sjöström, Johanna, Heikkilä, Reino, Hultborn, Ragnar, Malmström, Per, Bengtsson, Nils-Olof, Söderberg, Martin, Saksela, Eero, Blomqvist, Carl

“…The purpose of this study was to evaluate amplification of topoisomerase IIalpha (TOP2A) and HER2 genes as predictors of response to chemotherapy in advanced…”
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A simplified isotope release assay for cell-mediated cytotoxicity against anchorage dependent target cells by Timonen, T, Saksela, E

“…An assay for cell-mediated cytotoxicity has been developed in which anchorage-dependent target cells are cultured on small plastic beads in suspension…”
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Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-κB activation by Klefstrom, Juha, Arighi, Elena, Littlewood, Trevor, Jäättelä, Marja, Saksela, Eero, Evan, Gerard I., Alitalo, Kari

“…Normal fibroblasts are resistant to the cytotoxic action of tumor necrosis factor (TNF), but are rendered TNF‐sensitive upon deregulation of c‐Myc. To assess…”
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Cellular interactions in the augmentation of human NK activity by interferon by Saksela, E, Timonen, T, Cantell, K

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c‐Myc induces cellular susceptibility to the cytotoxic action of TNF‐alpha by Klefstrom, J., Västrik, I., Saksela, E., Valle, J., Eilers, M., Alitalo, K.

“…Tumor necrosis factor‐alpha (TNF) is a multifunctional cytokine which is cytotoxic for some tumor cells and transformed cells. The molecular mechanisms which…”
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A guinea pig's view on prostate cancer screening trials by Saksela, E

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Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells by Jäättelä, M, Ilvesmäki, V, Voutilainen, R, Stenman, U H, Saksela, E

“…We have previously demonstrated that tumor necrosis factor alpha (TNF-alpha), a multifunctional cytokine mainly produced by activated monocytes, inhibits the…”
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Prognostic markers in epithelial ovarian cancer by Saksela, E

“…Useful prognostic markers are available in certain areas of clinical management of epithelial ovarian tumors. CA125 and the flow cytometric determinants of DNA…”
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Fibronectin facilitates the migration of human natural killer cells by Somersalo, K, Saksela, E

“…The interaction of lymphocytes with the extracellular matrix plays an important role in the immune defence against tumor cells and virus-infected cells. We…”
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Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin. Immunohistochemical study of 30 cases using the MIB 1 antibody in formalin-fixed paraffin sections by Skalova, A, Leivo, I, Von Boguslawsky, K, Saksela, E

“…Immunohistochemical staining with the MIB 1 antibody was used to assess cell proliferation in 30 cases of acinic cell carcinoma of salivary glands. Until now,…”
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Stimulated natural killer cells secrete factors with chemotactic activity, including NAP-1/IL-8, which supports VLA-4- and VLA-5-mediated migration of T lymphocytes by Somersalo, K, Carpén, O, Saksela, E

“…In vivo, natural killer (NK) cells dominate among the early invading cells in allografts and virus-infected tissues, and they are followed later by an influx…”
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Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factors alpha and beta by Jäättelä, M, Saksela, K, Saksela, E

“…Elevated temperatures and a number of other types of stress induce synthesis of a small number of highly conserved proteins, the heat shock proteins, in a wide…”
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Involvement of β2-integrins in the migration of human natural killer cells by SOMERSALO, K, TARKKANEN, J, PATARROYO, M, SAKSELA, E

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