Search Results - "Sako, Kazuhiro"

Characterization of the buccal and gastric transit of orally disintegrating tablets in humans using gamma scintigraphy by Kambayashi, Atsushi, Sako, Kazuhiro, Kondo, Hiromu

“…[Display omitted] The present study characterized the buccal cavity-emptying and gastric-emptying kinetics of orally disintegrating tablets (ODTs) in fasted…”
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Scintigraphic evaluation of the in vivo performance of dry-coated delayed-release tablets in humans by Kambayashi, Atsushi, Sako, Kazuhiro, Kondo, Hiromu

“…In vitro dissolution (A) and in vivo onset of release (B) of delayed release tablet (DR). [Display omitted] We characterized the gastrointestinal (GI) transit…”
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Drug delivery to the intestinal lymph by oral formulations by Yoshida, Takayuki, Kojima, Hiroyuki, Sako, Kazuhiro, Kondo, Hiromu

“…Oral drug delivery systems (DDS) targeting lymphocytes in intestinal lymphatic vessels, ducts, and nodes are useful for treating diverse diseases. The…”
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Novel Orally Disintegrating Tablets Produced Using a High-Pressure Carbon Dioxides Process by Kobayashi, Masanori, Shinozuka, Daisuke, Kondo, Hiromu, Sako, Kazuhiro, Otake, Katsuto

“…It is well known that high-pressure carbon dioxide (CO2) lowers the glass transition temperature (Tg) of polymers. We therefore investigated whether Tg…”
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Polymer Combination Increased Both Physical Stability and Oral Absorption of Solid Dispersions Containing a Low Glass Transition Temperature Drug: Physicochemical Characterization and in Vivo Study by Sakurai, Atsushi, Sakai, Toshiro, Sako, Kazuhiro, Maitani, Yoshie

“…The purpose of this study was establishing a solid dispersion formulation containing a low glass transition temperature (Tg) and poorly water-soluble drug…”
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Remote assistance-focused strength training and nutritional guidance in preventing frailty on body composition and muscle strength in community-dwelling Japanese older adults during COVID-19 pandemic by Izumi, Shiro, Ujike, Shino, Shimosaka, Aya, Kitajo, Tomomi, Sawada, Chisato, Yamamoto, Satomi, Sako, Kazuhiro, Suzuki, Junko

“…This study aimed to investigate whether the implementation of a frailty prevention program using remote assistance combined with face-to-face guidance or…”
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Preoperative Predictive Factors of Short-Term Outcome in Idiopathic Normal Pressure Hydrocephalus by Kimura, Teruo, Yamada, Shigeki, Sugimura, Toshihide, Seki, Toshitaka, Miyano, Makoto, Fukuda, Shin, Takeuchi, Satoru, Miyata, Shiro, Tucker, Adam, Fujita, Tsutomu, Hashizume, Akira, Izumi, Naoto, Kawasaki, Kazutsune, Nakagaki, Atsushi, Sako, Kazuhiro

“…Surgical treatment of idiopathic normal pressure hydrocephalus (iNPH) by ventriculoperitoneal (VP) or lumboperitoneal (LP) shunting can achieve long-term…”
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Oral Sustained Release of a Hydrophilic Drug Using the Lauryl Sulfate Salt/Complex by Kasashima, Yuuki, Yoshihara, Keiichi, Yasuji, Takehiko, Sako, Kazuhiro, Uchida, Shinya, Namiki, Noriyuki

“…The objective of this study was to establish the key factor of the lauryl sulfate (LS) salt/complex for sustained release of a hydrophilic drug at various…”
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Aminoalkyl methacrylate copolymers for improving the solubility of tacrolimus. I: Evaluation of solid dispersion formulations by Yoshida, Takatsune, Kurimoto, Ippei, Yoshihara, Keiichi, Umejima, Hiroyuki, Ito, Naoki, Watanabe, Shunsuke, Sako, Kazuhiro, Kikuchi, Akihiko

“…The aim of this study was to investigate the effect of Eudragit E®/HCl (E-SD) on the reprecipitation of a poorly water-soluble drug, tacrolimus. To evaluate…”
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Influence of Manufacturing Factors on Physical Stability and Solubility of Solid Dispersions Containing a Low Glass Transition Temperature Drug by Sakurai, Atsushi, Sako, Kazuhiro, Maitani, Yoshie

“…In this study, we investigated the effect of manufacturing factors such as particle size, water content and manufacturing method on the physical stability and…”
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Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets by Kojima, Hiroyuki, Yoshihara, Keiichi, Sawada, Toyohiro, Kondo, Hiromu, Sako, Kazuhiro

“…The purpose of this study was to evaluate the feasibility of using a counter polymer in polyethylene oxide (PEO)/polyethylene glycol (PEG) polymeric matrices…”
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Assessment of Tacrolimus Absorption From the Human Intestinal Tract: Open-Label, Randomized, 4-Way Crossover Study by Tsunashima, Daisuke, Kawamura, Akio, PhD, Murakami, Manabu, MS, Sawamoto, Taiji, PhD, Undre, Nas, PhD, Brown, Malcolm, MD, Groenewoud, Albert, MD, PhD, Keirns, James J., PhD, Holman, John, MD, PhD, Connor, Alyson, PhD, Wylde, Hannah, PhD, Wilding, Ian, PhD, Ogawara, Ken-ichi, PhD, Sako, Kazuhiro, PhD, Higaki, Kazutaka, PhD, First, Roy, MD

“…Abstract Background Tacrolimus is an established immunosuppressant used for the prevention and treatment of allograft rejection in solid organ transplantation…”
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Trade-offs in Oral Drug Product Development by Kondo, Hiromu, Sako, Kazuhiro

“…Drug products are developed to meet multiple targets, thereby increasing their value. Pharmaceutical scientists encounter several trade-offs during the…”
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Formulation Design and Evaluation of Liposomal Sepantronium Bromide (YM155), a Small-Molecule Survivin Suppressant, Based on Pharmacokinetic Modeling and Simulation by Shakushiro, Kohsuke, Kawano, Hiroki, Nakata, Mari, Kita, Aya, Maeda, Atsushi, Watanabe, Shunsuke, Sako, Kazuhiro, Oku, Naoto

“…Purpose Sepantronium bromide (YM155) is administered by 168-hour continuous infusions in clinical studies due to its time-dependent pharmacological efficacy…”
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Antitumor efficacy and biodistribution of liposomal sepantronium bromide (YM155), a novel small-molecule survivin suppressant by Kawano, Hiroki, Shakushiro, Kohsuke, Nakata, Mari, Kita, Aya, Maeda, Atsushi, Watanabe, Shunsuke, Sako, Kazuhiro, Oku, Naoto

“…[Display omitted] •Liposomal YM155 greatly improved the level of YM155 circulating in the blood.•Liposomal YM155 showed unexpectedly high accumulation in the…”
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Effects of dissolved state of aminoalkyl methacrylate copolymer E/HCl on solubility enhancement effect for poorly water-soluble drugs by Yoshida, Takatsune, Kurimoto, Ippei, Umejima, Hiroyuki, Watanabe, Shunsuke, Sako, Kazuhiro, Kikuchi, Akihiko

“…Eudragit® E/HCl salt (E–SD) displays a good antireprecipitation effect on solid dispersion formulations of poorly water-soluble drugs. To elucidate the…”
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Impact of process parameters on Mg–St content and tablet surface wettability in the external lubrication method for a rotary tablet press by Kamiya, Takayuki, Kondo, Hisami, Hiroma, Hiroyuki, Yamashita, Kazunari, Hakomori, Tadashi, Sako, Kazuhiro, Iwao, Yasunori, Noguchi, Shuji, Itai, Shigeru

“…[Display omitted] •Tablet wettability by external lubrication was lower than by internal method.•Tablet wettability can be controlled by the setting of…”
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The effect of food on the oral bioavailability of drugs: a review of current developments and pharmaceutical technologies for pharmacokinetic control by Yasuji, Takehiko, Kondo, Hiromu, Sako, Kazuhiro

“…Here we review the mediation of the food effects on drugs by pharmaceutical technologies. The pharmacokinetics of drugs are affected by the interaction of…”
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Influence of Binder Droplet Dimension on Granulation Rate during Fluidized Bed Granulation by Fujiwara, Maya, Dohi, Masafumi, Otsuka, Tomoko, Yamashita, Kazunari, Sako, Kazuhiro

“…Here, we statistically identified the critical factor of the granulation rate during the fluidized bed granulation process. Lactose was selected as the…”
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Mechanism of controlled drug release from a salting-out taste-masking system by Yoshida, Takayuki, Tasaki, Hiroaki, Maeda, Atsushi, Katsuma, Masataka, Sako, Kazuhiro, Uchida, Takahiro

“…A “salting-out taste-masking system” is a multiparticulate system consisting of a drug core, a salting-out layer containing salts and water-soluble polymers,…”
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