Search Results - "Sakers, Alexander"

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue by Merrick, David, Sakers, Alexander, Irgebay, Zhazira, Okada, Chihiro, Calvert, Catherine, Morley, Michael P, Percec, Ivona, Seale, Patrick

“…Metabolic health depends on the capacity of adipose tissue progenitor cells to undergo de novo adipogenesis. The cellular hierarchy and mechanisms governing…”
Get full text

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate by Wang, Wenshan, Ishibashi, Jeff, Trefely, Sophie, Shao, Mengle, Cowan, Alexis J., Sakers, Alexander, Lim, Hee-Woong, O’Connor, Sean, Doan, Mary T., Cohen, Paul, Baur, Joseph A., King, M. Todd, Veech, Richard L., Won, Kyoung-Jae, Rabinowitz, Joshua D., Snyder, Nathaniel W., Gupta, Rana K., Seale, Patrick

“…The precursor cells for metabolically beneficial beige adipocytes can alternatively become fibrogenic and contribute to adipose fibrosis. We found that cold…”
Get full text

EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex by Shapira, Suzanne N, Lim, Hee-Woong, Rajakumari, Sona, Sakers, Alexander P, Ishibashi, Jeff, Harms, Matthew J, Won, Kyoung-Jae, Seale, Patrick

“…The transcription factor early B-cell factor 2 (EBF2) is an essential mediator of brown adipocyte commitment and terminal differentiation. However, the…”
Get full text

PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism by Stine, Rachel R., Sakers, Alexander P., TeSlaa, Tara, Kissig, Megan, Stine, Zachary E., Kwon, Chan Wook, Cheng, Lan, Lim, Hee-Woong, Kaestner, Klaus H., Rabinowitz, Joshua D., Seale, Patrick

“…Metabolic pathways dynamically regulate tissue development and maintenance. However, the mechanisms that govern the metabolic adaptation of stem or progenitor…”
Get full text

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming by Holman, Corey D, Sakers, Alexander P, Calhoun, Ryan P, Cheng, Lan, Fein, Ethan C, Jacobs, Christopher, Tsai, Linus, Rosen, Evan D, Seale, Patrick

“…The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is…”
Get full text

Control of murine brown adipocyte development by GATA6 by Jun, Seoyoung, Angueira, Anthony R, Fein, Ethan C, Tan, Josephine M E, Weller, Angela H, Cheng, Lan, Batmanov, Kirill, Ishibashi, Jeff, Sakers, Alexander P, Stine, Rachel R, Seale, Patrick

“…Brown adipose tissue (BAT) is a thermogenic organ that protects animals against hypothermia and obesity. BAT derives from the multipotent paraxial mesoderm;…”
Get full text

Defining the lineage of thermogenic perivascular adipose tissue by Angueira, Anthony R., Sakers, Alexander P., Holman, Corey D., Cheng, Lan, Arbocco, Michelangella N., Shamsi, Farnaz, Lynes, Matthew D., Shrestha, Rojesh, Okada, Chihiro, Batmanov, Kirill, Susztak, Katalin, Tseng, Yu-Hua, Liaw, Lucy, Seale, Patrick

“…Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic…”
Get full text

Adipose-tissue plasticity in health and disease by Sakers, Alexander, De Siqueira, Mirian Krystel, Seale, Patrick, Villanueva, Claudio J.

“…Adipose tissue, colloquially known as “fat,” is an extraordinarily flexible and heterogeneous organ. While historically viewed as a passive site for energy…”
Get full text

Cholesteryl Ester Storage Disease Uncovered During Unusually Broad Genetic Screening for Hypercholesterolemia by Sakers, Alexander, Soffer, Daniel

“…Nothing to disclose. None. An 18-year-old woman is referred to Clinical Lipid Specialist after genetic testing revealed homozygous pathogenic mutations in the…”
Get full text

Recurrent Hypertriglyceridemia-Associated Pancreatitis in a Pregnant Woman Complicated by Severe Socioeconomic Insecurity by Sakers, Alexander, Chery, Godefroy, Condit, Courtney, Soffer, Daniel

“…Nothing to disclose. None. At 26 weeks gestation, a 24-year-old pregnant woman with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia (HTG) was…”
Get full text

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming by Holman, Corey D, Sakers, Alexander P, Calhoun, Ryan P, Cheng, Lan, Fein, Ethan C, Jacobs, Christopher, Tsai, Linus, Rosen, Evan D, Seale, Patrick

“…The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is…”
Get full text

Current and Emerging Therapies for Atherosclerotic Cardiovascular Disease Risk Reduction in Hypertriglyceridemia by Mszar, Reed, Bart, Sarah, Sakers, Alexander, Soffer, Daniel, Karalis, Dean G

“…Hypertriglyceridemia (HTG) is a prevalent medical condition in patients with cardiometabolic risk factors and is associated with an increased risk of…”
Get full text

National Survey of US Plastic Surgeon Experience with Female Genital Mutilation by Calvert, Catherine, Nathan, Shelby, Sakers, Alexander, Akinbiyi, Takintope, Percec, Ivona

“…BACKGROUND:Female genital mutilation (FGM) is a growing problem in the United States, with the past few decades showing a dramatic increase in prevalence. This…”
Get full text

Identification of a Mesenchymal Progenitor Cell Hierarchy in Adipose Tissue by Sakers, Alexander P

“…Adipose tissue plays a critical role in defending against metabolic disease by sequestering excess calories and preventing their harmful deposition in ectopic…”
Get full text