Search Results - "Sakellariou, Giorgos K."

Application of redox proteomics to skeletal muscle aging and exercise by McDonagh, Brian, Sakellariou, Giorgos K, Jackson, Malcolm J

“…Skeletal muscle represents a physiologically relevant model for the application of redox proteomic techniques to dissect its response to exercise and aging…”
Get more information

Redox homeostasis and age‐related deficits in neuromuscular integrity and function by Sakellariou, Giorgos K., Lightfoot, Adam P., Earl, Kate E., Stofanko, Martin, McDonagh, Brian

“…Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age‐related muscle atrophy (sarcopenia) and weakness,…”
Get full text

Ergogenic and Antioxidant Effects of Spirulina Supplementation in Humans by KALAFATI, Maria, JAMURTAS, Athanasios Z, NIKOLAIDIS, Michalis G, PASCHALIS, Vassilis, THEODOROU, Anastasios A, SAKELLARIOU, Giorgos K, KOUTEDAKIS, Yiannis, KOURETAS, Dimitris

“…Spirulina is a popular nutritional supplement that is accompanied by claiMSS for antioxidant and performance-enhancing effects. Therefore, the aim of the…”
Get full text

Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease by Nye, Gareth A, Sakellariou, Giorgos K, Degens, Hans, Lightfoot, Adam P

“…Mitochondria are no longer solely regarded as the cellular powerhouse; instead, they are now implicated in mediating a wide-range of cellular processes, in the…”
Get more information

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype by Sataranatarajan, Kavithalakshmi, Qaisar, Rizwan, Davis, Carol, Sakellariou, Giorgos K, Vasilaki, Aphrodite, Zhang, Yiqiang, Liu, Yuhong, Bhaskaran, Shylesh, McArdle, Anne, Jackson, Malcolm, Brooks, Susan V, Richardson, Arlan, Van Remmen, Holly

“…Our previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZnSOD, Sod1KO mice) have neuromuscular changes resulting in dramatic…”
Get full text

Role of superoxide–nitric oxide interactions in the accelerated age‐related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase by Sakellariou, Giorgos K., Pye, Deborah, Vasilaki, Aphrodite, Zibrik, Lea, Palomero, Jesus, Kabayo, Tabitha, McArdle, Francis, Van Remmen, Holly, Richardson, Arlan, Tidball, James G., McArdle, Anne, Jackson, Malcolm J.

“…Summary Mice lacking Cu,Zn superoxide dismutase (SOD1) show accelerated, age‐related loss of muscle mass. Lack of SOD1 may lead to increased superoxide,…”
Get full text

Proteomic strategies to unravel age-related redox signalling defects in skeletal muscle by Cobley, James N., Sakellariou, Giorgos K., Husi, Holger, McDonagh, Brian

“…Increased oxidative damage and disrupted redox signalling are consistently associated with age-related loss of skeletal muscle mass and function. Redox…”
Get full text

Differential Cysteine Labeling and Global Label-Free Proteomics Reveals an Altered Metabolic State in Skeletal Muscle Aging by McDonagh, Brian, Sakellariou, Giorgos K, Smith, Neil T, Brownridge, Philip, Jackson, Malcolm J

“…The molecular mechanisms underlying skeletal muscle aging and associated sarcopenia have been linked to an altered oxidative status of redox-sensitive…”
Get full text

Redox proteomic analysis of the gastrocnemius muscle from adult and old mice by McDonagh, Brian, Sakellariou, Giorgos K., Smith, Neil T., Brownridge, Philip, Jackson, Malcolm J.

“…The data provides information in support of the research article, “Differential Cysteine Labeling and Global Label-Free Proteomics Reveals an Altered Metabolic…”
Get full text

Redox Homeostasis in Age-Related Muscle Atrophy by Sakellariou, Giorgos K, McDonagh, Brian

“…Muscle atrophy and weakness, characterized by loss of lean muscle mass and function, has a significant effect on the independence and quality of life of older…”
Get more information

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy by Sakellariou, Giorgos K., Pearson, Timothy, Lightfoot, Adam P., Nye, Gareth A., Wells, Nicola, Giakoumaki, Ifigeneia I., Vasilaki, Aphrodite, Griffiths, Richard D., Jackson, Malcolm J., McArdle, Anne

“…Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The…”
Get full text

Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle by Sakellariou, Giorgos K, McDonagh, Brian, Porter, Helen, Giakoumaki, Ifigeneia I, Earl, Kate E, Nye, Gareth A, Vasilaki, Aphrodite, Brooks, Susan V, Richardson, Arlan, Van Remmen, Holly, McArdle, Anne, Jackson, Malcolm J

“…Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1 ) leads to accelerated age-related muscle loss and weakness, but specific…”
Get more information

Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice by Sakellariou, Giorgos K., Davis, Carol S., Shi, Yun, Ivannikov, Maxim V., Zhang, Yiqiang, Vasilaki, Aphrodite, Macleod, Gregory T., Richardson, Arlan, Van Remmen, Holly, Jackson, Malcolm J., McArdle, Anne, Brooks, Susan V.

“…Deletion of copper‐zinc superoxide dismutase (CuZnSOD) in Sod1–/– mice leads to accelerated loss of muscle mass and force during aging, but the losses do not…”
Get full text

Long‐term administration of the mitochondria‐targeted antioxidant mitoquinone mesylate fails to attenuate age‐related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle by Sakellariou, Giorgos K., Pearson, Timothy, Lightfoot, Adam P., Nye, Gareth A., Wells, Nicola, Giakoumaki, Ifigeneia I., Griffiths, Richard D., McArdle, Anne, Jackson, Malcolm J.

“…ABSTRACT Age‐related skeletal muscle dysfunction is the underlying cause of morbidity that affects up to half the population aged 80 and over. Considerable…”
Get full text

The effect of lengthening contractions on neuromuscular junction structure in adult and old mice by Vasilaki, Aphrodite, Pollock, Natalie, Giakoumaki, Ifigeneia, Goljanek-Whysall, Katarzyna, Sakellariou, Giorgos K., Pearson, Timothy, Kayani, Anna, Jackson, Malcolm J., McArdle, Anne

“…Skeletal muscles of old mice demonstrate a profound inability to regenerate fully following damage. Such a failure could be catastrophic to older individuals…”
Get full text

SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes by Lightfoot, Adam P, Sakellariou, Giorgos K, Nye, Gareth A, McArdle, Francis, Jackson, Malcolm J, Griffiths, Richard D, McArdle, Anne

“…TNF-α is a key inflammatory mediator and is proposed to induce transcriptional responses via the mitochondrial generation of Reactive Oxygen Species (ROS). The…”
Get full text

Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England by Earl, Kate E, Sakellariou, Giorgos K, Sinclair, Melanie, Fenech, Manuel, Croden, Fiona, Owens, Daniel J, Tang, Jonathan, Miller, Alastair, Lawton, Clare, Dye, Louise, Close, Graeme L, Fraser, William D, McArdle, Anne, Beadsworth, Michael B J

“…ObjectiveSevere vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic…”
Get full text

Favorable and Prolonged Changes in Blood Lipid Profile after Muscle-Damaging Exercise by NIKOLAIDIS, Michalis G, PASCHALIS, Vassilis, GIAKAS, Giannis, FATOUROS, Ioannis G, SAKELLARIOU, Giorgos K, THEODOROU, Anastasios A, KOUTEDAKIS, Yiannis, JAMURTAS, Athanasios Z

“…To examine the effect of repeated muscle-damaging exercise on the time-course changes in blood lipid and lipoprotein profile and compare them with changes in…”
Get full text

Accelerated age-related loss of muscle mass in homozygotic SOD1 knockout mice is not associated with neuronal oxidative damage by Sakellariou, Giorgos K., Lightfoot, Adam P., Vasilaki, Aphrodite, Nye, Gareth, Van Remmen, Holly, Brooks, Susan, McArdle, Anne, Jackson, Malcolm J.

Get full text

PP68 - Accelerated age-related loss of muscle mass in homozygotic SOD1 knockout mice is not associated with neuronal oxidative damage by Sakellariou, Giorgos K., Lightfoot, Adam P., Vasilaki, Aphrodite, Nye, Gareth, Van Remmen, Holly, Brooks, Susan, McArdle, Anne, Jackson, Malcolm J.

Get full text