Search Results - "Sakaue, Hiroshi"

Adipocyte Death and Chronic Inflammation in Obesity by Kuroda, Masashi, Sakaue, Hiroshi

“…Cell death is closely linked to many diseases including cancer, neurodegenerative diseases, autoimmune diseases, and metabolic disorders. Increased adipocyte…”
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Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis by Dong, Bingzi, Hiasa, Masahiro, Higa, Yoshiki, Ohnishi, Yukiyo, Endo, Itsuro, Kondo, Takeshi, Takashi, Yuichi, Tsoumpra, Maria, Kainuma, Risa, Sawatsubashi, Shun, Kiyonari, Hiroshi, Shioi, Go, Sakaue, Hiroshi, Nakashima, Tomoki, Kato, Shigeaki, Abe, Masahiro, Fukumoto, Seiji, Matsumoto, Toshio

“…Exercise results in mechanical loading of the bone and stimulates energy expenditure in the adipose tissue. It is therefore likely that the bone secretes…”
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Monitoring of muscle mass in critically ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices by Nakanishi, Nobuto, Tsutsumi, Rie, Okayama, Yoshihiro, Takashima, Takuya, Ueno, Yoshitoyo, Itagaki, Taiga, Tsutsumi, Yasuo, Sakaue, Hiroshi, Oto, Jun

“…Skeletal muscle atrophy commonly occurs in critically ill patients, and decreased muscle mass is associated with worse clinical outcomes. Muscle mass can be…”
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The Utility of Urinary Titin to Diagnose and Predict the Prognosis of Acute Myocardial Infarction by Arase, Miharu, Nakanishi, Nobuto, Tsutsumi, Rie, Kawakami, Ayuka, Arai, Yuta, Sakaue, Hiroshi, Oto, Jun

“…Early detection and management are crucial for better prognosis in acute myocardial infarction (AMI). Serum titin, a component of the sarcomere in cardiac and…”
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Diaper-zero program (prompted voiding care) improves diaper use in nursing home residents by Kohno, Kazuyo, Umemoto, Nobuhiko, Tsutsumi, Rie, Kawakami, Ayuka, Sakaue, Hiroshi, Tamura, Kyousuke, Morishita, Teruhiro, Taketani, Yutaka, Uyama, Kimihito, Takeda, Eiji

“…With an aging population, the number of older adults admitted to nursing homes has increased. Diapers are often used to manage nursing home resident urinary…”
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Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes by Harada, Nagakatsu, Gotoda, Yuka, Hatakeyama, Adzumi, Nakagawa, Tadahiko, Miyatake, Yumiko, Kuroda, Masashi, Masumoto, Saeko, Tsutsumi, Rie, Nakaya, Yutaka, Sakaue, Hiroshi

“…ACTN2 and ACTN3 encode sarcomeric α-actinin-2 and α-actinin-3 proteins, respectively, that constitute the Z-line in mammalian skeletal muscle fibers. In human…”
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Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription by Kuroda, Masashi, Nishiguchi, Misa, Ugawa, Naho, Ishikawa, Etsuko, Kawabata, Yasuyo, Okamoto, Saya, Sasaki, Waka, Miyatake, Yumiko, Sebe, Mayu, Masumoto, Saeko, Tsutsumi, Rie, Harada, Nagakatsu, Sakaue, Hiroshi

“…Hypertrophy, associated with adipocyte dysfunction, causes increased pro-inflammatory adipokine, and abnormal glucose and lipid metabolism, leading to insulin…”
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Comparison of water balance among healthy young and old adults and handicapped adults by Ide, Noriko, Satomura, Shigeko, Tsutsumi, Rie, Kawakami, Ayuka, Sakaue, Hiroshi, Katayama, Takafumi, Sonogi, Natsue, Yamaji, Takako, Sakaguchi, Yoko, Takeda, Eiji

“…The body’s water balance is changed by food and beverage intake, metabolism, and excretion. In this study, we performed a cross-sectional study that…”
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Assessment of insulin resistance in the skeletal muscle of mice using positron emission tomography/computed tomography imaging by Miyatake, Yumiko, Mishima, Yuna, Tsutsumi, Rie, Otani, Tamaki, Suemasa, Naoya, Masumoto, Saeko, Kuroda, Masashi, Sakaue, Hiroshi

“…Measuring glucose uptake in the skeletal muscle in vivo is an effective method to determine glucose metabolism abnormalities as the skeletal muscle is the…”
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Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression by Kim Chung, Le Thi, Hosaka, Toshio, Yoshida, Masaki, Harada, Nagakatsu, Sakaue, Hiroshi, Sakai, Tohru, Nakaya, Yutaka

“…Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor (GLP-1R) agonist that has been used as a drug injected subcutaneously for treatment of type 2 diabetes…”
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Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes by Kawakami, Ayuka, Bando, Mika, Takashi, Tomoe, Sugiuchi, Mizuki, Hyodo, Mizusa, Mishima, Yuna, Kuroda, Masashi, Mori, Hiroyasu, Kuroda, Akio, Yumoto, Hiromichi, Matsuhisa, Munehide, Sakaue, Hiroshi, Tsutsumi, Rie

“…Objective : Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This…”
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Inflammatory Cytokine-Induced Muscle Atrophy and Weakness Can Be Ameliorated by an Inhibition of TGF-β-Activated Kinase-1 by Kanai, Mai, Ganbaatar, Byambasuren, Endo, Itsuro, Ohnishi, Yukiyo, Teramachi, Jumpei, Tenshin, Hirofumi, Higa, Yoshiki, Hiasa, Masahiro, Mitsui, Yukari, Hara, Tomoyo, Masuda, Shiho, Yamagami, Hiroki, Yamaguchi, Yuki, Aihara, Ken-Ichi, Sebe, Mayu, Tsutsumi, Rie, Sakaue, Hiroshi, Matsumoto, Toshio, Abe, Masahiro

“…Chronic inflammation causes muscle wasting. Because most inflammatory cytokine signals are mediated via TGF-β-activated kinase-1 (TAK1) activation,…”
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Taste receptor gene expression is associated with decreased eGFR in patients with diabetes by Beppu, Kana, Kawakami, Ayuka, Mishima, Yuna, Tsutsumi, Rie, Kuroda, Masashi, Mori, Hiroyasu, Kuroda, Akio, Matsuhisa, Munehisa, Sakaue, Hiroshi

“…Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the…”
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Necessity of daily 1000-IU vitamin D supplementation for maintaining a sufficient vitamin D status by Ikezumi, Yuya, Matsuura, Yasushi, Morishita, Teruhiro, Ide, Noriko, Kitada, Isao, Katayama, Takafumi, Tsutsumi, Rie, Sakaue, Hiroshi, Taketani, Yutaka, Sairyo, Koichi, Takeda, Eiji

“…The changes in the serum 25-hydroxyvitamin D (25(OH)D) concentrations after daily 1000-IU vitamin D intake for 3 months (3-month-VD), 6 months (6-month-VD) and…”
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Partially Hydrolyzed Guar Gum Intake Supports the Gut Microbiota and Attenuates Inflammation during Influenza H1N1 Virus Infection in Mice by Kato, Takahiro, Kamiya, Satoshi, Narasaki, Soshi, Sumii, Ayako, Tsutsumi, Yasuo M, Machida, Kyoka, Hara, Kanako, Izumi-Mishima, Yuna, Tsutsumi, Rie, Sakaue, Hiroshi

“…Partially hydrolyzed guar gum (PHGG) is a soluble dietary fiber that is effective for defecation control. It influences the gut microbiota, by which it is…”
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DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression by Kuroda, Masashi, Onoyama, Rumi, Sasaki, Waka, Sebe, Mayu, Kitamura, Tadahiro, Masumoto, Saeko, Tsutsumi, Rie, Harada, Nagakatsu, Sakaue, Hiroshi

“…Researchers frequently use 3T3-L1 adipocytes as a fat cell line, but the capacity of this line for insulin-mediated glucose transport is lower than that of…”
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Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice by Okamatsu-Ogura, Yuko, Fukano, Keigo, Tsubota, Ayumi, Nio-Kobayashi, Junko, Nakamura, Kyoko, Morimatsu, Masami, Sakaue, Hiroshi, Saito, Masayuki, Kimura, Kazuhiro

“…We previously reported brown adipocytes can proliferate even after differentiation. To test the involvement of mature adipocyte proliferation in cell number…”
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Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation by Kihira, Yoshitaka, Miyake, Mariko, Hirata, Manami, Hoshina, Yoji, Kato, Kana, Shirakawa, Hitoshi, Sakaue, Hiroshi, Yamano, Noriko, Izawa-Ishizawa, Yuki, Ishizawa, Keisuke, Ikeda, Yasumasa, Tsuchiya, Koichiro, Tamaki, Toshiaki, Tomita, Shuhei

“…It is known that obese adipose tissues are hypoxic and express hypoxia-inducible factor (HIF)-1α. Although some studies have shown that the expression of…”
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Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity by Miyake, Masato, Zhang, Jun, Yasue, Akihiro, Hisanaga, Satoshi, Tsugawa, Kazue, Sakaue, Hiroshi, Oyadomari, Miho, Kiyonari, Hiroshi, Oyadomari, Seiichi

“…The eIF2α phosphorylation-dependent integrated stress response (ISR) is a signaling pathway that maintains homeostasis in mammalian cells exposed to various…”
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The association between sarcopenia and functional outcomes in patients undergoing convalescent rehabilitation by Yamasaki, Yuki, Honda, Yui, Inoue-Umezaki, Mami, Makieda, Ryoko, Endo, Yoko, Hanayama, Kozo, Sakaue, Hiroshi, Teramoto, Fusako

“…Sarcopenia is widely believed to be linked to poorer outcomes in inpatient rehabilitation. This study aimed to assess the impact of sarcopenia on functional…”
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