A case of gastric follicular lymphoma resected and diagnosed with laparoscopy and endoscopy cooperative surgery

A woman in her 70s was diagnosed with a protruding mucosa-associated lymphoid tissue (MALT) lymphoma during a secondary health examination. After eradication of Helicobacter pylori, a biopsy revealed gastric follicular lymphoma (FL) and the lesion was still protruding one year later. F-fluorodeoxygl...

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Bibliographic Details
Published in:	Nippon Shōkakibyō Gakkai zasshi Vol. 114; no. 11; p. 1996
Main Authors:	Seike, Takuya, Inamura, Katsuhisa, Okuno, Noriko, Asaumi, Yoshihide, Takata, Yoshiko, Okamura, Toshiyuki, Matano, Sadaya, Terahata, Shintaro, Sakatoku, Kohmei, Kawai, Hiroshi
Format:	Journal Article
Language:	Japanese
Published:	Japan 2017
Subjects:	Aged Female Gastroscopy Helicobacter Infections Helicobacter pylori Humans Laparoscopy Lymphoma, Follicular - diagnosis Lymphoma, Follicular - surgery Stomach Neoplasms - diagnosis Stomach Neoplasms - surgery
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Summary:	A woman in her 70s was diagnosed with a protruding mucosa-associated lymphoid tissue (MALT) lymphoma during a secondary health examination. After eradication of Helicobacter pylori, a biopsy revealed gastric follicular lymphoma (FL) and the lesion was still protruding one year later. F-fluorodeoxyglucose positron emission tomography showed focal nodular hypermetabolic activity, suggesting that FL may have transformed into a diffuse large B-cell lymphoma. Upper gastrointestinal endoscopy, colonoscopy, and capsule endoscopy showed no other lesions in the gastrointestinal tract, and bone marrow biopsy showed no permeation into the marrow. Therefore, this lesion, which appeared as a submucosal tumor, was limited to the stomach. Laparoscopy and endoscopy cooperative surgery was performed, because it allows for correct pathological diagnosis while removing only a minimal portion of the stomach wall. Histological findings showed follicular structures consisting of abnormal lymphoid cells. Immunohistochemical analysis revealed that neoplastic cells were positive for CD20, CD79a, Bcl-2, CD10, and c-MYC, but negative for CD3, CD5, and cyclin D1. Finally, we diagnosed this lesion as a primary gastric FL.
ISSN:	0446-6586
DOI:	10.11405/nisshoshi.114.1996