Search Results - "Sakata, Natsumi"

Double prenylation of SNARE protein Ykt6 is required for lysosomal hydrolase trafficking by Sakata, Natsumi, Shirakawa, Ryutaro, Goto, Kota, Trinh, Duc Anh, Horiuchi, Hisanori

“…Ykt6 is an evolutionarily conserved SNARE protein regulating Golgi membrane fusion and other diverse membrane trafficking pathways. Unlike most SNARE proteins,…”
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Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP by Shishikura, Kyosuke, Horiuchi, Takahiro, Sakata, Natsumi, Trinh, Duc‐Anh, Shirakawa, Ryutaro, Kimura, Tomohiro, Asada, Yujiro, Horiuchi, Hisanori

“…Background and Purpose Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded…”
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Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity by Horiuchi, Takahiro, Sakata, Natsumi, Narumi, Yoshihiro, Kimura, Tomohiro, Hayashi, Takashi, Nagano, Keisuke, Liu, Keyue, Nishibori, Masahiro, Tsukita, Sohei, Yamada, Tetsuya, Katagiri, Hideki, Shirakawa, Ryutaro, Horiuchi, Hisanori

“…Metformin is the first-line drug in the treatment of type 2 diabetes. In addition to its hypoglycemic effect, metformin has an anti-inflammatory function, but…”
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Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma by Yoshimachi, Shingo, Shirakawa, Ryutaro, Cao, Mingxin, Trinh, Duc Anh, Gao, Pan, Sakata, Natsumi, Miyazaki, Kento, Goto, Kota, Miura, Takayuki, Ariake, Kyohei, Maeda, Shimpei, Masuda, Kunihiro, Ishida, Masaharu, Ohtsuka, Hideo, Unno, Michiaki, Horiuchi, Hisanori

“…The small GTPases RalA and RalB are members of the Ras family and activated downstream of Ras. Ral proteins are found in GTP‐bound active and GDP‐bound…”
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Identification of fucosylated haptoglobin‐producing cells in pancreatic cancer tissue and its molecular mechanism by Ito, Nami, Yamada, Momoko, Morishita, Koichi, Nojima, Satoshi, Motooka, Kei, Sakata, Natsumi, Asuka, Tatsuya, Otsu, Ryoji, Takamatsu, Shinji, Kamada, Yoshihiro, Mori, Soichiro, Akita, Hirofumi, Eguchi, Hidetoshi, Morii, Eiichi, Miyoshi, Eiji

“…Fucosylated haptoglobin is a well-established glyco-biomarker of pancreatic cancer. We recently established a novel anti-glycan antibody (10-7G mAb) that…”
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Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis by Trinh, Duc-Anh, Shirakawa, Ryutaro, Kimura, Tomohiro, Sakata, Natsumi, Goto, Kota, Horiuchi, Hisanori

“…Ribosome biogenesis is essential for maintaining basic cellular activities although its mechanism is not fully understood. Inhibitor of growth 4 (ING4) is a…”
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Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis by Motooka, Kei, Morishita, Koichi, Ito, Nami, Shinzaki, Shinichiro, Tashiro, Taku, Nojima, Satoshi, Shimizu, Kayoko, Date, Mutsuhiro, Sakata, Natsumi, Yamada, Momoko, Takamatsu, Shinji, Kamada, Yoshihiro, Iijima, Hideki, Mizushima, Tsunekazu, Morii, Eiichi, Takehara, Tetsuo, Miyoshi, Eiji

“…Inflammatory bowel disease (IBD) is a chronic, relapsing inflammation of the digestive tract. Although fecal and serum biomarkers have been extremely important…”
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Transcription factor SP1 regulates haptoglobin fucosylation via induction of GDP-fucose transporter 1 in the hepatoma cell line HepG2 by Kondo, Jumpei, Sakata, Natsumi, Morishita, Koichi, Hayashibara, Ayumu, Sakon, Daisuke, Takamatsu, Shinji, Asakura, Nobuhiko, Suzuki, Takashi, Miyoshi, Eiji

“…Fucosylation is involved in cancer and inflammation, and several fucosylated proteins, such as AFP-L3 for hepatocellular carcinoma, are used as cancer…”
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The anti-inflammatory effect of metformin: The molecular targets by Sakata, Natsumi

“…Metformin is an anti-diabetic drug. Metformin mainly inhibits gluconeogenesis in the liver and reduces blood sugar. In addition to the anti-diabetic effects,…”
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Prostaglandin E 2 inhibits neutrophil extracellular trap formation through production of cyclic AMP by Shishikura, Kyosuke, Horiuchi, Takahiro, Sakata, Natsumi, Trinh, Duc‐Anh, Shirakawa, Ryutaro, Kimura, Tomohiro, Asada, Yujiro, Horiuchi, Hisanori

“…Background and Purpose Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded…”
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Soybean extract inhibits influenza virus entry: Mechanistic insights by Sakata, Natsumi, Horio, Yuka, Yamaji, Ryoichi, Isegawa, Yuji

“…Influenza viruses pose significant public health threats because they can cause seasonal outbreaks and global pandemics. Current preventive measures, including…”
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A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus by Shirakawa, Ryutaro, Goto‐Ito, Sakurako, Goto, Kota, Wakayama, Shonosuke, Kubo, Haremaru, Sakata, Natsumi, Trinh, Duc Anh, Yamagata, Atsushi, Sato, Yusuke, Masumoto, Hiroshi, Cheng, Jinglei, Fujimoto, Toyoshi, Fukai, Shuya, Horiuchi, Hisanori

“…Protein prenylation is essential for many cellular processes including signal transduction, cytoskeletal reorganization, and membrane trafficking. Here, we…”
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Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production by Cao, Mingxin, Li, Xinming, Trinh, Duc-Anh, Yoshimachi, Shingo, Goto, Kota, Sakata, Natsumi, Ishida, Masaharu, Ohtsuka, Hideo, Unno, Michiaki, Wang, Yuxia, Shirakawa, Ryutaro, Horiuchi, Hisanori

“…Pancreatic ductal adenocarcinoma (PDAC), caused by activating mutations in K-Ras, is an aggressive malignancy due to its early invasion and metastasis. Ral…”
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