Search Results - "Sakata, Kei"

Metabolic Reprogramming Commits Differentiation of Human CD27 + IgD + B Cells to Plasmablasts or CD27 - IgD - Cells by Torigoe, Masataka, Iwata, Shigeru, Nakayamada, Shingo, Sakata, Kei, Zhang, Mingzeng, Hajime, Maiko, Miyazaki, Yusuke, Narisawa, Manabu, Ishii, Koji, Shibata, Hirotaka, Tanaka, Yoshiya

“…B cells play a crucial role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). However, the relevance of the metabolic…”
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Hydrogen Permeation Behavior of Scratch Formed on Zn Coated Steels in Simulated Atmospheric Corrosion Environment by Sakata, Kei, Sakairi, Masatoshi, Kinugasa, Junichiro

“…In this study, the electrochemical hydrogen permeation technique was introduced to investigate the relationship between scratch shape and hydrogen permeation…”
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Contribution of the Interleukin‐6/STAT‐3 Signaling Pathway to Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Kondo, Masahiro, Yamaoka, Kunihiro, Sakata, Kei, Sonomoto, Koshiro, Lin, Lin, Nakano, Kazuhisa, Tanaka, Yoshiya

“…Objective Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into chondrocytes. Articular cartilage contains MSC‐like chondroprogenitor…”
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Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells by Miyagawa, Ippei, Nakayamada, Shingo, Nakano, Kazuhisa, Yamagata, Kaoru, Sakata, Kei, Yamaoka, Kunihiro, Tanaka, Yoshiya

“…Human mesenchymal stem cells (MSCs) are multipotent and exert anti-inflammatory effects, but the underlying mechanism remains to be elucidated. In the current…”
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Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus by Sakata, Kei, Nakayamada, Shingo, Miyazaki, Yusuke, Kubo, Satoshi, Ishii, Akina, Nakano, Kazuhisa, Tanaka, Yoshiya

“…Aberrant and persistent production of interferon-α (IFN-α) by plasmacytoid dendritic cells (pDCs) is known to play a key role in the pathogenesis of systemic…”
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Janus Kinase Inhibitor Baricitinib Modulates Human Innate and Adaptive Immune System by Kubo, Satoshi, Nakayamada, Shingo, Sakata, Kei, Kitanaga, Yukihiro, Ma, Xiaoxue, Lee, Seunghyun, Ishii, Akina, Yamagata, Kaoru, Nakano, Kazuhisa, Tanaka, Yoshiya

“…The purpose of this study was to elucidate the mechanism of action of baricitinib on Janus kinase (JAK)/signal transducer and activator of transcription (STAT)…”
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Hydrogen Permeation Behavior of Scratch on Zn Coated Steel during 1000 Hours Wet and Dry Corrosion Test by Sakata, Kei, Sakairi, Masatoshi, Kinugasa, Junichiro

“…In this study, hydrogen permeation current from scratch formed on Zn coated steel during 1000 h wet and dry cyclic corrosion test was investigated. The scratch…”
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Th22 Cells Promote Osteoclast Differentiation via Production of IL-22 in Rheumatoid Arthritis by Miyazaki, Yusuke, Nakayamada, Shingo, Kubo, Satoshi, Nakano, Kazuhisa, Iwata, Shigeru, Miyagawa, Ippei, Ma, Xiaoxue, Trimova, Gulzhan, Sakata, Kei, Tanaka, Yoshiya

“…T helper (Th) cells can differentiate into functionally distinct subsets and play a pivotal role in inflammatory and autoimmune diseases such as rheumatoid…”
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Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression by Kawabe, Akio, Yamagata, Kaoru, Kato, Shigeaki, Nakano, Kazuhisa, Sakata, Kei, Tsukada, Yu-Ichi, Ohmura, Koichiro, Nakayamada, Shingo, Tanaka, Yoshiya

“…Rheumatoid arthritis (RA) patients present with abnormal methylation patterns in their fibroblast-like synoviocytes (FLS). Given that DNA demethylation is…”
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Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis by Ishikawa, Yuichi, Iwata, Shigeru, Hanami, Kentaro, Nawata, Aya, Zhang, Mingzeng, Yamagata, Kaoru, Hirata, Shintaro, Sakata, Kei, Todoroki, Yasuyuki, Nakano, Kazuhisa, Nakayamada, Shingo, Satoh, Minoru, Tanaka, Yoshiya

“…Dermatomyositis (DM) with rapidly progressive interstitial lung disease (DM RP-ILD) is a life-threatening condition. Serum cytokine levels are potentially…”
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Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation by Miyazaki, Yusuke, Nakayamada, Shingo, Kubo, Satoshi, Ishikawa, Yuichi, Yoshikawa, Maiko, Sakata, Kei, Iwata, Shigeru, Miyagawa, Ippei, Nakano, Kazuhisa, Tanaka, Yoshiya

“…Objectives B cell depletion by rituximab (RTX) is an effective treatment for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV)…”
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Does a Mother's Early Return to Work after Childbirth Improve Her Future Employment Status? by Kureishi, Wataru, McKenzie, Colin, Sakata, Kei, Wakabayashi, Midori

“…We examine whether a mother's early return to work after her first birth improves her employment status in the short term and the long term (3 and 10/12 years…”
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Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold by Sonomoto, Koshiro, Yamaoka, Kunihiro, Kaneko, Hiroaki, Yamagata, Kaoru, Sakata, Kei, Zhang, Xiangmei, Kondo, Masahiro, Zenke, Yukichi, Sabanai, Ken, Nakayamada, Shingo, Sakai, Akinori, Tanaka, Yoshiya

“…Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid…”
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mTOR activation in CD8+ cells contributes to disease activity of rheumatoid arthritis and increases therapeutic response to TNF inhibitors by Zhang, Mingzeng, Iwata, Shigeru, Sonomoto, Koshiro, Ueno, Masanobu, Fujita, Yuya, Anan, Junpei, Miyazaki, Yusuke, Ohkubo, Naoaki, Sumikawa, Maiko Hajime, Todoroki, Yasuyuki, Miyata, Hiroko, Nagayasu, Atsushi, Kanda, Ryuichiro, Hao, He, Trimova, Gulzhan, Lee, Seunghyun, Nakayamada, Shingo, Sakata, Kei, Tanaka, Yoshiya

“…Abstract Objective This study aimed to understand the role of mammalian target of rapamycin (mTOR) in CD8+ cells in the pathogenicity of RA and the changes…”
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Use it too much and lose everything? The effects of hours of work on health by Kajitani, Shinya, McKenzie, Colin, Sakata, Kei

“…In this paper, we extend the ‘use it or lose it’ hypothesis to analyse whether the negative effects of working hours eventually dominate the positive effects…”
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Pathological role of activated mTOR in CXCR3+ memory B cells of rheumatoid arthritis by Iwata, Shigeru, Zhang, Mingzeng, Hajime, Maiko, Ohkubo, Naoaki, Sonomoto, Koshiro, Torimoto, Keiichi, Kitanaga, Yukihiro, Trimova, Gulzhan, Todoroki, Yasuyuki, Miyata, Hiroko, Ueno, Masanobu, Nagayasu, Atsushi, Kanda, Ryuichiro, Nakano, Kazuhisa, Nakayamada, Shingo, Sakata, Kei, Tanaka, Yoshiya

“…B cells play an important pathological role in RA. In this study, we investigated the role of metabolic regulator mTOR in B cells and its relevance to the…”
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Tofacitinib, a JAK inhibitor, inhibits human B cell activation in vitro by Wang, Sheau-Pey, Iwata, Shigeru, Nakayamada, Shingo, Sakata, Kei, Yamaoka, Kunihiro, Tanaka, Yoshiya

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Characterization of photosystem II assembly complexes containing ONE-HELIX PROTEIN1 in Arabidopsis thaliana by Maeda, Hanaki, Takahashi, Koharu, Ueno, Yoshifumi, Sakata, Kei, Yokoyama, Akari, Yarimizu, Kozue, Myouga, Fumiyoshi, Shinozaki, Kazuo, Ozawa, Shin-Ichiro, Takahashi, Yuichiro, Tanaka, Ayumi, Ito, Hisashi, Akimoto, Seiji, Takabayashi, Atsushi, Tanaka, Ryouichi

“…The assembly process of photosystem II (PSII) requires several auxiliary proteins to form assembly intermediates. In plants, early assembly intermediates…”
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Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells by Iwata, Shigeru, Zhang, Mingzeng, Hao, He, Trimova, Gulzhan, Hajime, Maiko, Miyazaki, Yusuke, Ohkubo, Naoaki, Satoh Kanda, Yurie, Todoroki, Yasuyuki, Miyata, Hiroko, Ueno, Masanobu, Nagayasu, Atsushi, Nakayamada, Shingo, Sakata, Kei, Tanaka, Yoshiya

“…Recent reports have shown the importance of IFN-γ and T-bet B cells in the pathology of SLE, suggesting the involvement of IFN-γ-producing T-bet CD4 cells,…”
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Identification of a Potent and Orally Active Non-peptide C5a Receptor Antagonist by Sumichika, Hiroshi, Sakata, Kei, Sato, Noriko, Takeshita, Sanae, Ishibuchi, Seigo, Nakamura, Mitsuharu, Kamahori, Takao, Ehara, Syuji, Itoh, Katsuhiko, Ohtsuka, Tatsuyuki, Ohbora, Tomoko, Mishina, Tadashi, Komatsu, Hirotsugu, Naka, Yoichi

“…The anaphylatoxin C5a is a potent chemotactic factor for neutrophils and other leukocytes, and functions as an important inflammatory mediator. Through a high…”
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