Search Results - "Sakashita, Chiharu"

Structure-activity relationship study of leucinostatin A, a modulator of tumor−stroma interaction by Abe, Hikaru, Kawada, Manabu, Sakashita, Chiharu, Watanabe, Takumi, Shibasaki, Masakatsu

“…Structure-activity relationship study of leucinostatin A, a natural nonapeptide, was performed to gain insight into the structural requirements for…”
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Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin‐like growth factor‐1 secretion by prostate stromal cells by Ohishi, Tomokazu, Abe, Hikaru, Sakashita, Chiharu, Saqib, Uzma, Baig, Mirza S., Ohba, Shun‐ichi, Inoue, Hiroyuki, Watanabe, Takumi, Shibasaki, Masakatsu, Kawada, Manabu

“…Modulation of prostate stromal cells (PrSCs) within tumor tissues is gaining attention for the treatment of solid tumors. Using our original in vitro coculture…”
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Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor–Stroma Interaction by Abe, Hikaru, Ouchi, Hitoshi, Sakashita, Chiharu, Kawada, Manabu, Watanabe, Takumi, Shibasaki, Masakatsu

“…Total synthesis of leucinostatin A, a modulator of tumor‐stroma interactions, using asymmetric catalyses, a nitroaldol reaction, thioamide‐aldol reaction,…”
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Author Correction: Androprostamine A: a unique antiprostate cancer agent by Yamazaki, Yohko, Abe, Hikaru, Sakashita, Chiharu, Ohba, Shun-Ichi, Watanabe, Takumi, Momose, Isao, Kawada, Manabu

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Androprostamine A: a unique antiprostate cancer agent by Yamazaki, Yohko, Abe, Hikaru, Sakashita, Chiharu, Ohba, Shun-Ichi, Watanabe, Takumi, Momose, Isao, Kawada, Manabu

“…The androgen receptor (AR) is an important therapeutic target for all clinical states of prostate cancer. We screened cultured broths of microorganisms for…”
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Synthesis of Androprostamine A and Resormycin by Abe, Hikaru, Yamazaki, Yohko, Sakashita, Chiharu, Momose, Isao, Watanabe, Takumi, Shibasaki, Masakatsu

“…Syntheses of androprostamine A (1), and resormycin (3), anti-prostate cancer peptidyl natural products produced by microorganisms, were completed. The…”
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Synthesis and Structure–Activity Relationship Study of NBRI16716B, an Antitumor Natural Product by Abe, Hikaru, Sakashita, Chiharu, Kawada, Manabu, Nomoto, Akio, Watanabe, Takumi, Shibasaki, Masakatsu

“…The total synthesis of NBRI16716B (2), a naturally occurring modulator of tumor–stroma interactions, was successfully achieved. Using this synthetic route, a…”
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Biological activity of intervenolin analogs with a phenyl substituent by Abe, Hikaru, Kawada, Manabu, Igarashi, Masayuki, Ohba, Shun-ichi, Hayashi, Chigusa, Sakashita, Chiharu, Watanabe, Takumi, Shibasaki, Masakatsu

“…Intervenolin analogs with a phenyl substituent at the 2- or 3-position were synthesized. The compounds ( 3 – 11 ) showed weak or no inhibitory activity toward…”
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Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment by Yoshida, Junjiro, Ohishi, Tomokazu, Abe, Hikaru, Ohba, Shun-ichi, Inoue, Hiroyuki, Usami, Ihomi, Amemiya, Masahide, Oriez, Raphael, Sakashita, Chiharu, Dan, Shingo, Sugawara, Minoru, Kawaguchi, Tokuichi, Ueno, Junko, Asano, Yuko, Ikeda, Ami, Takamatsu, Manabu, Amori, Gulanbar, Kondoh, Yasumitsu, Honda, Kaori, Osada, Hiroyuki, Noda, Tetsuo, Watanabe, Takumi, Shimizu, Takao, Shibasaki, Masakatsu, Kawada, Manabu

“…The disruption of the tumor microenvironment (TME) is a promising anti-cancer strategy, but its effective targeting for solid tumors remains unknown. Here, we…”
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Catalytic Asymmetric Total Synthesis and Stereochemical Revision of LeucinostatinA: A Modulator of Tumor-Stroma Interaction by Abe, Hikaru, Ouchi, Hitoshi, Sakashita, Chiharu, Kawada, Manabu, Watanabe, Takumi, Shibasaki, Masakatsu

“…Total synthesis of leucinostatinA, a modulator of tumor-stroma interactions, using asymmetric catalyses, a nitroaldol reaction, thioamide-aldol reaction,…”
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Abstract A122: Anti- Helicobacter pylori activity of a novel derivative of intervenolin by Kawada, Manabu, Ohishi, Tomokazu, Abe, Hikaru, Hayashi, Chigusa, Sakashita, Chiharu, Ohba, Shun-ichi, Inoue, Hiroyuki, Igarashi, Masayuki, Watanabe, Takumi, Shibasaki, Masakatsu

“…Abstract Helicobacter pylori (H. pylori) infection plays a critical role in pathogenesis of gastric ulcer and gastric cancer. Thus, the eradication of H…”
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