Search Results - "Sakane, Hiroshi"

The Major Lysosomal Membrane Proteins LAMP-1 and LAMP-2 Participate in Differentiation of C2C12 Myoblasts by Sakane, Hiroshi, Akasaki, Kenji

“…Lysosomes are organelles that play a crucial role in the degradation of endocytosed molecules, phagocytosed macromolecules and autophagic substrates. The…”
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LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse by Sakane, Hiroshi, Yamamoto, Hideki, Kikuchi, Akira

“…β-catenin-mediated Wnt signaling is crucial in animal development and tumor progression. The phosphorylation of low-density lipoprotein receptor-related…”
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Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling by Sakane, Hiroshi, Yamamoto, Hideki, Matsumoto, Shinji, Sato, Akira, Kikuchi, Akira

“…Glypicans are members of the heparan sulfate proteoglycans (HSPGs) and are involved in various growth factor signaling mechanisms. Although HSPGs affect the…”
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An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis by Hanaki, Hideaki, Yamamoto, Hideki, Sakane, Hiroshi, Matsumoto, Shinji, Ohdan, Hideki, Sato, Akira, Kikuchi, Akira

“…Wnt5a is a representative ligand that activates the β-catenin-independent pathway in Wnt signaling. It was reported that the expression of Wnt5a in human…”
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α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor by Sakane, Hiroshi, Horii, Yukimi, Nogami, Satoru, Kawano, Yoji, Kaneko-Kawano, Takako, Shirataki, Hiromichi

“…Membrane traffic plays a crucial role in delivering proteins and lipids to their intracellular destinations. We previously identified α-taxilin as a binding…”
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TSG101, a tumor susceptibility gene, bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression by Sai, Xu Bin, Makiyama, Tomohiko, Sakane, Hiroshi, Horii, Yukimi, Hiraishi, Hideyuki, Shirataki, Hiromichi

“…Tumor susceptibility gene 101 (TSG101) was initially identified in fibroblasts as a tumor suppressor gene but subsequent studies show that TSG101 also…”
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Identification of a second amphipathic lipid-packing sensor-like motif that contributes to Gcs1p function in the early endosome-to-TGN pathway by Zendeh-boodi, Zahra, Yamamoto, Takaharu, Sakane, Hiroshi, Tanaka, Kazuma

“…ArfGAPs, GTPase-activating proteins for Arf small GTPases, are involved in multiple steps of vesicle formation of various transport pathways. Amphipathic…”
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The Functional Relationship between the Cdc50p-Drs2p Putative Aminophospholipid Translocase and the Arf GAP Gcs1p in Vesicle Formation in the Retrieval Pathway from Yeast Early Endosomes to the TGN by Sakane, Hiroshi, Yamamoto, Takaharu, Tanaka, Kazuma

“…Drs2p, the catalytic subunit of the Cdc50p-Drs2p putative aminophospholipid translocase, has been implicated in conjunction with the Arf1 signaling pathway in…”
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Apicobasal secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by distinct mechanisms by Yamamoto, Hideki, Awada, Chihiro, Hanaki, Hideaki, Sakane, Hiroshi, Tsujimoto, Ikuko, Takahashi, Yuko, Takao, Toshifumi, Kikuchi, Akira

“…Wnts are glycan- and lipid-modified morphogens that are important for cellular responses, but how Wnt is secreted in polarized epithelial cells remains…”
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Comparative study of the steady-state subcellular distribution of lysosome-associated membrane glycoprotein-2 (LAMP-2) isoforms with GYXXΦ-type tyrosine-based motifs that interact differently with four adaptor protein (AP) complexes by Yamaguchi, Fumiaki, Sakane, Hiroshi, Akasaki, Kenji

“…Abstract Lysosome-associated membrane protein-1 and -2 (LAMP-1 and LAMP-2, respectively) are type I transmembrane proteins. LAMP-2 comprises three splice…”
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Wnt5a regulates distinct signalling pathways by binding to Frizzled2 by Sato, Akira, Yamamoto, Hideki, Sakane, Hiroshi, Koyama, Hirofumi, Kikuchi, Akira

“…Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the specificity of these pathways is not well understood. This study…”
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Regulation of Hook1-mediated endosomal sorting of clathrin-independent cargo by γ-taxilin by Higashi, Satoru, Makiyama, Tomohiko, Sakane, Hiroshi, Nogami, Satoru, Shirataki, Hiromichi

“…In clathrin-independent endocytosis, Hook1, a microtubule- and cargo-tethering protein, participates in sorting of cargo proteins such as CD98 (encoded by…”
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Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling by Yamamoto, Hideki, Sakane, Hiroshi, Yamamoto, Hideki, Michiue, Tatsuo, Kikuchi, Akira

“…Wnt and Dickkopf (Dkk) regulate the stabilization of β-catenin antagonistically in the Wnt signaling pathway; however, the molecular mechanism is not clear. In…”
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Involvement of lysosomal integral membrane protein-2 in the activation of autophagy by Sakane, Hiroshi, Urabe, Junna, Nakahira, Saki, Hino, Katsumi, Miyata, Nao, Akasaki, Kenji

“…Lysosomal integral membrane protein-2 (LIMP-2) is a type III transmembrane protein that is highly glycosylated and mainly localized to the lysosomal membrane…”
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The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms by Yamamoto, Hideki, Awada, Chihiro, Hanaki, Hideaki, Sakane, Hiroshi, Tsujimoto, Ikuko, Takahashi, Yuko, Takao, Toshifumi, Kikuchi, Akira

“…Wnts are glycan- and lipid-modified morphogens that are important for cellular responses, but how Wnts are secreted in polarized epithelial cells remains…”
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[beta]â[euro]Taxilin participates in differentiation of C2C12 myoblasts into myotubes by Sakane, Hiroshi, Makiyama, Tomohiko, Nogami, Satoru, Horii, Yukimi, Akasaki, Kenji, Shirataki, Hiromichi

“…Myogenesis is required for the development of skeletal muscle. Accumulating evidence indicates that the expression of several genes are upregulated during…”
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β‐Taxilin participates in differentiation of C2C12 myoblasts into myotubes by Sakane, Hiroshi, Makiyama, Tomohiko, Nogami, Satoru, Horii, Yukimi, Akasaki, Kenji, Shirataki, Hiromichi

“…Myogenesis is required for the development of skeletal muscle. Accumulating evidence indicates that the expression of several genes are upregulated during…”
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γ-Taxilin temporally regulates centrosome disjunction in a Nek2A-dependent manner by Makiyama, Tomohiko, Higashi, Satoru, Sakane, Hiroshi, Nogami, Satoru, Shirataki, Hiromichi

“…Never in mitosis A-related kinase 2A (Nek2A), a centrosomal serine/threonine kinase, is involved in mitotic progression by regulating the centrosome cycle…”
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Expression of α-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation by Horii, Yukimi, Sakane, Hiroshi, Nogami, Satoru, Ohtomo, Natsuko, Tomiya, Tomoaki, Shirataki, Hiromichi

“…α-Taxilin, a binding partner of the syntaxin family, is a candidate tumor marker. To gain insight into the physiological role of α-taxilin in normal tissues,…”
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Expression of [alpha]-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation by Horii, Yukimi, Sakane, Hiroshi, Nogami, Satoru, Ohtomo, Natsuko, Tomiya, Tomoaki, Shirataki, Hiromichi

“…[alpha]-Taxilin, a binding partner of the syntaxin family, is a candidate tumor marker. To gain insight into the physiological role of [alpha]-taxilin in…”
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