Cardioprotective effects of extracts from Psidium guajava L and Limonium wrightii, Okinawan medicinal plants, against ischemia-reperfusion injury in perfused rat hearts

The aim of this study was to determine whether the medicinal herbs growing in Okinawa and possessing a radical-scavenging activity would exert cardioprotective effects against ischemia-reperfusion injury using isolated perfused rat hearts. Effects of the aqueous extracts from Psidium guajava L. and...

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Bibliographic Details
Published in:	Pharmacology Vol. 67; no. 3; p. 128
Main Authors:	Yamashiro, Satoshi, Noguchi, Katsuhiko, Matsuzaki, Toshihiro, Miyagi, Kanako, Nakasone, Junko, Sakanashi, Mayuko, Sakanashi, Makoko, Kukita, Ichiro, Aniya, Yoko, Sakanashi, Matao
Format:	Journal Article
Language:	English
Published:	Switzerland 01-03-2003
Subjects:	Animals Catalase - pharmacology Free Radical Scavengers - pharmacology Gallic Acid - pharmacology In Vitro Techniques Japan Male Myocardial Contraction - drug effects Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Phytotherapy Plant Extracts - pharmacology Plant Leaves Plumbaginaceae - chemistry Psidium - chemistry Quercetin - pharmacology Rats Rats, Sprague-Dawley Superoxide Dismutase - pharmacology Time Factors Ventricular Function, Left - drug effects Japan
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Summary:	The aim of this study was to determine whether the medicinal herbs growing in Okinawa and possessing a radical-scavenging activity would exert cardioprotective effects against ischemia-reperfusion injury using isolated perfused rat hearts. Effects of the aqueous extracts from Psidium guajava L. and Limonium wrightii at concentrations having an equipotent radical-scavenging activity on myocardial injury produced by global ischemia followed by reperfusion were tested and were further compared with those of quercetin and gallic acid, major antioxidative components of P. guajava L. and L. wrightii, respectively. Both extracts significantly attenuated ischemic contracture during ischemia and improved myocardial dysfunction after reperfusion. Decreases in high-energy phosphates and increases in malondialdehyde in the reperfused hearts were significantly lessened with both plant extracts. Quercetin and gallic acid also exerted similar beneficial effects. These results indicate that P. guajava L. and L. wrightii both have cardioprotective effects against myocardial ischemia-reperfusion injury in isolated rat hearts, primarily through their radical-scavenging actions.
ISSN:	0031-7012
DOI:	10.1159/000067799