Search Results - "Sakamuro, D"

Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation by Kumari, A, Iwasaki, T, Pyndiah, S, Cassimere, E K, Palani, C D, Sakamuro, D

“…The transcription factor adenovirus E2 promoter-binding factor (E2F)-1 normally enhances cell-cycle progression, but it also induces apoptosis under certain…”
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The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage by Cassimere, E K, Pyndiah, S, Sakamuro, D

“…The E2F1 transcription factor, which was originally identified as a cell-cycle initiator, mediates apoptosis in response to DNA damage. As E2F1-induced…”
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Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells by Sakamuro, D, Furukawa, T, Takegami, T

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Bin1 mediates apoptosis by c-Myc in transformed primary cells by DUHADAWAY, James B, SAKAMURO, Daitoku, EWERT, Donald L, PRENDERGAST, George C

“…The Bin1 gene encodes a c-Myc-interacting adapter protein with tumor suppressor and cell death properties. In this study, we offer evidence that Bin1…”
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Enhancement human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8 by Murayama, T, Kuno, K, Jisaki, F, Obuchi, M, Sakamuro, D, Furukawa, T, Mukaida, N, Matsushima, K

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Detection of human cytomegalovirus genome in uterus tissue by FURUKAWA, T, JISAKI, F, SAKAMURO, D, TAKEGAMI, T, MURAYAMA, T

“…To analyze persistent infection by human cytomegalovirus (HCMV) in vivo, specimens obtained from various sources and autopsied organs were examined for the…”
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New Myc-interacting proteins: a second Myc network emerges by Sakamuro, D, Prendergast, G C

“…Despite its intensive investigation for almost two decades, c-Myc remains a fascinating and enigmatic subject. A large and compelling body of evidence…”
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The polyproline region of p53 is required to activate apoptosis but not growth arrest by SAKAMURO, D, SABBATINI, P, WHITE, E, PRENDERGAST, G. C

“…p53 is a pivotal regulator of apoptosis but its mechanism of action is obscure. We report that the polyproline (PP) region located between p53's…”
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Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system by OKAZAKI, Toshihiko, SAKAMURO, Daitoku

“…The Fas/CD95/APO-1 ligand (FasL) is a death cytokine that binds to cell surface Fas/CD95/APO-1 receptor, yet a possible role of FasL expression in…”
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Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome by Murayama, T, Tsuchiya, N, Jisaki, F, Ozaki, M, Sakamuro, D, Hirai, K, Shimizu, S, Ito, K, Matsushima, K, Furukawa, T

“…Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic…”
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BIN1 is a novel MYC-interacting protein with features of a tumour suppressor by Sakamuro, Daitoku, Elliott, Katharine J, Wechsler-Reya, Robert, Prendergast, George C

“…BIN1 is a novel protein that interacts with the functionally critical Myc box regions at the N terminus of the MYC oncoprotein. BIN1 is structurally related to…”
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Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment by LEBOWITZ, P. F, SAKAMURO, D, PRENDERGAST, G. C

“…Farnesyl transferase inhibitors (FTIs) are a novel class of antitumor drugs that block the oncogenic activity of Ras. Because FTIs lack significant cell…”
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c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms by Sakamuro, D, Eviner, V, Elliott, K J, Showe, L, White, E, Prendergast, G C

“…We tested the hypothesis that wild-type p53 activity is required for c-Myc-dependent apoptosis in epithelial cells. Primary baby rat kidney epithelial cell…”
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Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing by Wechsler-Reya, R, Sakamuro, D, Zhang, J, Duhadaway, J, Prendergast, G C

“…BIN1 is a putative tumor suppressor that was identified through its interaction with the MYC oncoprotein. To begin to identify elements of BIN1 whose…”
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Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms by ELLIOTT, K, SAKAMURO, D, PRENDERGAST, G. C, BASU, A, WEI DU, WUNNER, W, STALLER, P, GAUBATZ, S, HONG ZHANG, PROCHOWNIK, E, EILERS, M

“…The tumor suppressor Bin1 was identified through its interaction with the N-terminal region of Myc which harbors its transcriptional activation domain. Here we…”
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Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma by Ge, Kai, Minhas, Farooq, Duhadaway, James, Mao, Nien‐Chen, Wilson, Darren, Buccafusca, Roberto, Sakamuro, Daitoku, Nelson, Peter, Malkowicz, S. Bruce, Tomaszewski, John, Prendergast, George C.

“…The genetic events underlying the development of prostate cancer are poorly defined. c‐Myc is often activated in tumors that have progressed to metastatic…”
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Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity by Ge, K, Duhadaway, J, Sakamuro, D, Wechsler-Reya, R, Reynolds, C, Prendergast, G C

“…Oncogenic activation of MYC occurs often in breast carcinoma and is associated with poor prognosis. Loss or inactivation of mechanisms that restrain MYC may…”
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POLYMORPHONUCLEAR CELL FACTOR FOUND IN PATIENTS WITH RHEUMATOID ARTHRITIS by WAKITANI, SHIGEYUKI, SAKAMURO, DAITOKU, OCHI, TAKAHIRO, OWAKI, HAJIME, FUJIMOTO, MASAHIRO, ONO, KEIRO

“…The polymorphonuclear (PMN) cell factor was detected in patients with rheumatoid arthritis. The factor was found to stimulate human synovial cells to produce…”
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Detection of a unique γ‐glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: A new candidate for early diagnosis of hepatocellular carcinoma by Tsutsumi, M, Sakamuro, D, Takada, A, Zang, S, Furukawa, T, Taniguchi, N

“…Many studies concerning γ‐glutamyl transpeptidase (GGTP) in hepatocellular carcinoma (HCC) have suggested that changes in hepatic GGTP expression may be…”
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Losses of the tumor suppressor BINI in breast carcinoma are frequent and reflect deficits in programmed cell death capacity by GE, K, DUHADAWAY, J, SAKAMURO, D, WECHSLER-REYA, R, REYNOLDS, C, PRENDERGAST, G. C

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