Search Results - "Sakamoto, Taiichi"

Specific inhibition of FGF5-induced cell proliferation by RNA aptamers by Amano, Ryo, Namekata, Masato, Horiuchi, Masataka, Saso, Minami, Yanagisawa, Takuya, Tanaka, Yoichiro, Ghani, Farhana Ishrat, Yamamoto, Masakuni, Sakamoto, Taiichi

“…Fibroblast growth factor 5 (FGF5) is a crucial regulator of hair growth and an oncogenic factor in several human cancers. To generate FGF5 inhibitors, we…”
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Homo-trimeric structure of the ribonuclease for rRNA processing, FAU-1, from Pyrococcus furiosus by Kawai, Gota, Okada, Kiyoshi, Baba, Seiki, Sato, Asako, Sakamoto, Taiichi, Kanai, Akio

“…Crystal structure of a ribonuclease for rRNA processing, FAU-1, from Pyrococcus furiosus was determined with the resolution of 2.57 Å in a homo-trimeric form…”
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Binding interaction analysis of RNA aptamer-Fc region of human immunoglobulin G using fragment molecular orbital calculation by Yoshida, Hisae, Sato, Koki, Ishikawa, Takeshi, Sakamoto, Taiichi, Yamagishi, Kenji

“…[Display omitted] •Base flipping conformation of the G7 nucleotide of the RNA aptamer is critical for hFc1 binding.•Base-flipped G7 nucleotide shows robust…”
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Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1 by Nameki, Nobukazu, Takizawa, Masayuki, Suzuki, Takayuki, Tani, Shoko, Kobayashi, Naohiro, Sakamoto, Taiichi, Muto, Yutaka, Kuwasako, Kanako

“…SURP domains are exclusively found in splicing‐related proteins in all eukaryotes. SF3A1, a component of the U2 snRNP, has two tandem SURP domains, SURP1, and…”
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A G‐quadruplex‐forming RNA aptamer binds to the MTG8 TAFH domain and dissociates the leukemic AML1‐MTG8 fusion protein from DNA by Fukunaga, Junichi, Nomura, Yusuke, Tanaka, Yoichiro, Torigoe, Hidetaka, Nakamura, Yoshikazu, Sakamoto, Taiichi, Kozu, Tomoko

“…MTG8 (RUNX1T1) is a fusion partner of AML1 (RUNX1) in the leukemic chromosome translocation t(8;21). The AML1‐MTG8 fusion gene encodes a chimeric transcription…”
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NMR monitoring of the SELEX process to confirm enrichment of structured RNA by Amano, Ryo, Aoki, Kazuteru, Miyakawa, Shin, Nakamura, Yoshikazu, Kozu, Tomoko, Kawai, Gota, Sakamoto, Taiichi

“…RNA aptamers are RNA molecules that bind to a target molecule with high affinity and specificity using uniquely-folded tertiary structures. RNA aptamers are…”
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Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G by Miyakawa, Shin, Nomura, Yusuke, Sakamoto, Taiichi, Yamaguchi, Yoshiki, Kato, Koichi, Yamazaki, Satoko, Nakamura, Yoshikazu

“…Potential applications for functional RNAs are rapidly expanding, not only to address functions based on primary nucleotide sequences, but also by RNA aptamer,…”
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Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5'-untraslated region by Yamaguchi, Katsutoshi, Asakura, Kiryu, Imamura, Masataka, Kawai, Gota, Sakamoto, Taiichi, Furihata, Tomomi, Linhardt, Robert J, Igarashi, Kazuei, Toida, Toshihiko, Higashi, Kyohei

“…Glycosaminoglycans (GAGs), a group of structurally related acidic polysaccharides, are primarily found as glycan moieties of proteoglycans (PGs). Among these,…”
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Conformational plasticity of RNA for target recognition as revealed by the 2.15 Å crystal structure of a human IgG-aptamer complex by Nomura, Yusuke, Sugiyama, Shigeru, Sakamoto, Taiichi, Miyakawa, Shin, Adachi, Hiroaki, Takano, Kazufumi, Murakami, Satoshi, Inoue, Tsuyoshi, Mori, Yusuke, Nakamura, Yoshikazu, Matsumura, Hiroyoshi

“…Aptamers are short single-stranded nucleic acids with high affinity to target molecules and are applicable to therapeutics and diagnostics. Regardless of an…”
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Development of the 12-Base Short Dimeric Myogenetic Oligodeoxynucleotide That Induces Myogenic Differentiation by Umezawa, Koji, Ikeda, Rena, Sakamoto, Taiichi, Enomoto, Yuya, Nihashi, Yuma, Shinji, Sayaka, Shimosato, Takeshi, Kagami, Hiroshi, Takaya, Tomohide

“…A myogenetic oligodeoxynucleotide (myoDN), iSN04 (5'-AGA TTA GGG TGA GGG TGA-3'), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin…”
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Altered‐specificity mutants of the HIV Rev arginine‐rich motif‐RRE IIB interaction by Raad, Nicole G., Ghattas, Ingrid R., Amano, Ryo, Watanabe, Natsuki, Sakamoto, Taiichi, Smith, Colin A.

“…Arginine‐rich motifs (ARMs) bind RNA structures with high affinity and specificity, and the human immunodeficiency virus (HIV) exploits ARM‐RNA interactions to…”
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Two stems with different characteristics and an internal loop in an RNA aptamer contribute to spermine-binding by Oguro, Akihiro, Yanagida, Asumi, Fujieda, Yuta, Amano, Ryo, Otsu, Maina, Sakamoto, Taiichi, Kawai, Gota, Matsufuji, Senya

“…Though polyamines (putrescine, spermidine, and spermine) bind to the specific position in RNA molecules, interaction mechanisms are poorly understood. SELEX…”
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Amelioration of Alzheimer's Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model by Minamisawa, Mayumi, Sato, Yuma, Ishiguro, Eitarou, Taniai, Tetsuyuki, Sakamoto, Taiichi, Kawai, Gota, Saito, Takashi, Saido, Takaomi C

“…In this study, we observed disease progression, changes in the gut microbiota, and interactions among the brain, liver, pancreas, and intestine in a mouse…”
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A trifunctional, triangular RNA–protein complex by Ohuchi, Shoji J., Sagawa, Fumihiko, Sakamoto, Taiichi, Inoue, Tan

“…•Three RNA segments were designed to produce a trifunctional triangular shaped RNP.•The protein-attached segments assemble to form the RNP via kissing loop…”
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Altering the orientation of a fused protein to the RNA-binding ribosomal protein L7Ae and its derivatives through circular permutation by Ohuchi, Shoji J., Sagawa, Fumihiko, Sakamoto, Taiichi, Inoue, Tan

“…RNA-protein complexes (RNPs) are useful for constructing functional nano-objects because a variety of functional proteins can be displayed on a designed RNA…”
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Conjugation of two RNA aptamers improves binding affinity to AML1 Runt domain by Nomura, Yusuke, Yamazaki, Kaori, Amano, Ryo, Takada, Kenta, Nagata, Takashi, Kobayashi, Naohiro, Tanaka, Yoichiro, Fukunaga, Junichi, Katahira, Masato, Kozu, Tomoko, Nakamura, Yoshikazu, Haishima, Yuji, Torigoe, Hidetaka, Sakamoto, Taiichi

“…To develop a high-affinity aptamer against AML1 Runt domain, two aptamers were conjugated based on their structural information. The newly designed aptamer…”
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Solution structure of a DNA mimicking motif of an RNA aptamer against transcription factor AML1 Runt domain by Nomura, Yusuke, Tanaka, Yoichiro, Fukunaga, Jun-ichi, Fujiwara, Kazuya, Chiba, Manabu, Iibuchi, Hiroaki, Tanaka, Taku, Nakamura, Yoshikazu, Kawai, Gota, Kozu, Tomoko, Sakamoto, Taiichi

“…AML1/RUNX1 is an essential transcription factor involved in the differentiation of hematopoietic cells. AML1 binds to the Runt-binding double-stranded DNA…”
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Mammalian Bcnt/Cfdp1, a potential epigenetic factor characterized by an acidic stretch in the disordered N-terminal and Ser250 phosphorylation in the conserved C-terminal regions by Iwashita, Shintaro, Suzuki, Takehiro, Yasuda, Takeshi, Nakashima, Kentaro, Sakamoto, Taiichi, Kohno, Toshiyuki, Takahashi, Ichiro, Kobayashi, Takayasu, Ohno-Iwashita, Yoshiko, Imajoh-Ohmi, Shinobu, Song, Si-Young, Dohmae, Naoshi

“…The BCNT (Bucentaur) superfamily is classified by an uncharacteristic conserved sequence of ∼80 amino acids (aa) at the C-terminus, BCNT-C (the conserved…”
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Characterization of a heat-stable enzyme possessing GTP-dependent RNA ligase activity from a hyperthermophilic archaeon, Pyrococcus furiosus by Kanai, Akio, Sato, Asako, Fukuda, Yoko, Okada, Kiyoshi, Matsuda, Takashi, Sakamoto, Taiichi, Muto, Yutaka, Yokoyama, Shigeyuki, Kawai, Gota, Tomita, Masaru

“…Using an expression protein library of a hyperthermophilic archaeon, Pyrococcus furiosus, we identified a gene (PF0027) that encodes a protein with heat-stable…”
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Thermodynamic study of aptamers binding to their target proteins by Sakamoto, Taiichi, Ennifar, Eric, Nakamura, Yoshikazu

“…Aptamers are nucleic acids that bind to a target molecule with high affinity and specificity, which are selected from systematic evolution of ligands by…”
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