Search Results - "Sakamoto, Kazuho"

Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α by Ono, Yuko, Sakamoto, Kazuho

“…Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or with various endogenous diseases that are associated with…”
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Mechanism of Statin-Induced Rhabdomyolysis by Sakamoto, Kazuho, Kimura, Junko

“…Statins, a group of drugs used for the treatment of hypercholesterolemia, have adverse effects on skeletal muscle. The symptoms of these effects range from…”
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Involvement of sex hormonal regulation of K+ channels in electrophysiological and contractile functions of muscle tissues by Sakamoto, Kazuho, Kurokawa, Junko

“…Sex hormones, such as testosterone, progesterone, and 17β-estradiol, control various physiological functions. This review focuses on the sex hormonal…”
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TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice by Ono, Yuko, Maejima, Yuko, Saito, Masafumi, Sakamoto, Kazuho, Horita, Shoichiro, Shimomura, Kenju, Inoue, Shigeaki, Kotani, Joji

“…Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or various endogenous diseases related to bacterial…”
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A Cellular Pharmacological Approach to the Development of Drugs to Treat Muscle Wasting by Sakamoto, Kazuho

“…Skeletal muscle atrophy reduces quality of life and increases mortality. However, there are few available drugs for the treatment of muscle atrophy. Recently,…”
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A deep learning algorithm to translate and classify cardiac electrophysiology by Aghasafari, Parya, Yang, Pei-Chi, Kernik, Divya C, Sakamoto, Kazuho, Kanda, Yasunari, Kurokawa, Junko, Vorobyov, Igor, Clancy, Colleen E

“…The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has been a critical in vitro advance in the study of patient-specific…”
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Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation by Maejima, Yuko, Aoyama, Masato, Sakamoto, Kazuho, Jojima, Teruo, Aso, Yoshimasa, Takasu, Katsuya, Takenosihita, Seiichi, Shimomura, Kenju

“…Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an…”
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DCEBIO facilitates myogenic differentiation via intermediate conductance Ca2+ activated K+ channel activation in C2C12 myoblasts by Tanaka, Shoko, Ono, Yuko, Sakamoto, Kazuho

“…Membrane hyperpolarization is suggested to be a trigger for skeletal muscle differentiation. We investigated whether DCEBIO, an opener of the…”
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Progress of sarcopenia research by Sakamoto, Kazuho

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Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach by Yajima, Kodai, Akiyoshi, Takeshi, Sakamoto, Kazuho, Suzuki, Yoshiaki, Oka, Takayuki, Imaoka, Ayuko, Yamamura, Hisao, Kurokawa, Junko, Ohtani, Hisakazu

“…Transporter-mediated clearance is determined by two factors, its single-molecule clearance, and expression level. However, no reliable method has been…”
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Opening of Intermediate Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway by Iseki, Yuzo, Ono, Yuko, Hibi, Chihiro, Tanaka, Shoko, Takeshita, Shunya, Maejima, Yuko, Kurokawa, Junko, Murakawa, Masahiro, Shimomura, Kenju, Sakamoto, Kazuho

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Ischemic preconditioning in skeletal muscle by Sakamoto, Kazuho

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Hypoxic Stress Induces Transient Receptor Potential Melastatin 2 (TRPM2) Channel Expression in Adult Rat Cardiac Fibroblasts by Takahashi, Kenji, Sakamoto, Kazuho, Kimura, Junko

“…When cardiac tissue is exposed to hypoxia, myocytes are damaged, while fibroblasts are activated. However, it is unknown what changes are induced by hypoxia in…”
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Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes by Tohyama, Shugo, Fujita, Jun, Fujita, Chihana, Yamaguchi, Miho, Kanaami, Sayaka, Ohno, Rei, Sakamoto, Kazuho, Kodama, Masami, Kurokawa, Junko, Kanazawa, Hideaki, Seki, Tomohisa, Kishino, Yoshikazu, Okada, Marina, Nakajima, Kazuaki, Tanosaki, Sho, Someya, Shota, Hirano, Akinori, Kawaguchi, Shinji, Kobayashi, Eiji, Fukuda, Keiichi

“…Cardiac regenerative therapies utilizing human induced pluripotent stem cells (hiPSCs) are hampered by ineffective large-scale culture. hiPSCs were cultured in…”
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Continued exposure of anti-cancer drugs to human iPS cell-derived cardiomyocytes can unmask their cardiotoxic effects by Sakamoto, Kazuho, Sakatoku, Kohei, Sugimoto, Shintaro, Iwasaki, Nanami, Sano, Yusuke, Yamaguchi, Masahiko, Kurokawa, Junko

“…Although the cardiotoxicity of anti-cancer drugs is an important issue, the underlying mechanisms remain unknown. To develop a sensitive assay system for…”
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Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes by Kodama, Masami, Furutani, Kazuharu, Kimura, Reiko, Ando, Tomoko, Sakamoto, Kazuho, Nagamori, Shushi, Ashihara, Takashi, Kurachi, Yoshihisa, Sekino, Yuko, Furukawa, Tetsushi, Kanda, Yasunari, Kurokawa, Junko

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool to characterize the pharmacology and toxic effects of drugs on heart…”
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Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels by Sakamoto, Kazuho, Suzuki, Yoshiaki, Yamamura, Hisao, Ohya, Susumu, Muraki, Katsuhiko, Imaizumi, Yuji

“…Voltage-gated K+ (KV) channels, which control firing and shape of action potentials in excitable cells, are supposed to be potential therapeutic targets in…”
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C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice by Ono, Yuko, Saito, Masafumi, Sakamoto, Kazuho, Maejima, Yuko, Misaka, Shingen, Shimomura, Kenju, Nakanishi, Nobuto, Inoue, Shigeaki, Kotani, Joji

“…Burn injury is the leading cause of death and disability worldwide and places a tremendous economic burden on society. Systemic inflammatory responses induced…”
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CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function by Dannhauser, Philip N., Camus, Stéphane M., Sakamoto, Kazuho, Sadacca, L. Amanda, Torres, Jorge A., Camus, Marine D., Briant, Kit, Vassilopoulos, Stéphane, Rothnie, Alice, Smith, Corinne J., Brodsky, Frances M.

“…Clathrins are cytoplasmic proteins that play essential roles in endocytosis and other membrane traffic pathways. Upon recruitment to intracellular membranes,…”
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DCEBIO facilitates myogenic differentiation via intermediate conductance Ca 2+ activated K + channel activation in C2C12 myoblasts by Tanaka, Shoko, Ono, Yuko, Sakamoto, Kazuho

“…Membrane hyperpolarization is suggested to be a trigger for skeletal muscle differentiation. We investigated whether DCEBIO, an opener of the…”
Get full text