Search Results - "Sakamoto, Aiji"

Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters by Kato, Ryuji, Nomura, Atsuo, Sakamoto, Aiji, Yasuda, Yuki, Amatani, Koyuha, Nagai, Sayuri, Sen, Yoko, Ijiri, Yoshio, Okada, Yoshikatsu, Yamaguchi, Takehiro, Izumi, Yasukatsu, Yoshiyama, Minoru, Tanaka, Kazuhiko, Hayashi, Tetsuya

“…The prevalence of sleep apnea is very high in patients with heart failure (HF). The aims of this study were to investigate the influence of intermittent…”
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Identification of a novel aldose reductase-like gene upregulated in the failing heart of cardiomyopathic hamster by Sakamoto, Aiji, Sugamoto, Yuka

“…Cardiomyopathy (CM) is degenerative disease of myocardium which leads to severe cardiac failure. Although many causative genes for CM have been identified,…”
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Both Hypertrophic and Dilated Cardiomyopathies are Caused by Mutation of the Same Gene, δ -sarcoglycan, in Hamster: An Animal Model of Disrupted Dystrophin-Associated Glycoprotein Complex by Sakamoto, Aiji, Ono, Kageyoshi, Abe, Makoto, Jasmin, Gaeten, Eki, Toshihiko, Murakami, Yasufumi, Masaki, Tomoh, Toyo-Oka, Teruhiko, Hanaoka, Fumio

“…Cardiomyopathy (CM) is a primary degenerative disease of myocardium and is traditionally categorized into hypertrophic and dilated CMs (HCM and DCM) according…”
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Isolation of a new line of Syrian hamster having a novel p.Leu262Pro mutation of tyrosinase with progressive pigmentation in its eyes and ears by Sakamoto, Aiji, Hirobe, Tomohisa

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Expression and function of ephrin-B1 and its cognate receptor EphB2 in human atherosclerosis: from an aspect of chemotaxis by Sakamoto, Aiji, Ishibashi-Ueda, Hatsue, Sugamoto, Yuka, Higashikata, Takeo, Miyamoto, Susumu, Kawashiri, Masa-Aki, Yagi, Kunimasa, Konno, Tetsuo, Hayashi, Kenshi, Fujino, Noboru, Ino, Hidekazu, Takeda, Yoshiyu, Yamagishi, Masakazu

“…Although several cytokines and chemokines have been demonstrated to play pivotal roles in the pathophysiological conditions of atherosclerosis, few findings…”
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Expression and Function of Ephrin-B1 and Its Cognate Receptor EphB2 in Human Abdominal Aortic Aneurysm by Sakamoto, Aiji, Kawashiri, Masaaki, Ishibashi-Ueda, Hatsue, Sugamoto, Yuka, Yoshimuta, Tsuyoshi, Higashikata, Takeo, Ogino, Hitoshi, Tada, Hayato, Konno, Tetsuo, Hayashi, Kenshi, Yamagishi, Masakazu

“…We examined the expression of ephrin-B1 and its cognate receptor EphB2, key regulators of angiogenesis and embryogenesis, in human abdominal aortic aneurysm…”
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Application of real-time RT-PCR to quantifying gene expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human abdominal aortic aneurysm by Higashikata, Takeo, Yamagishi, Masakazu, Sasaki, Hiroaki, Minatoya, Kenji, Ogino, Hitoshi, Ishibashi-Ueda, Hatsue, Hao, Hiroyuki, Nagaya, Noritoshi, Tomoike, Hitonobu, Sakamoto, Aiji

“…Backgound: The relative expression levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), key regulators in remodeling…”
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Cloning and functional expression of human cDNA for the ETB endothelin receptor by Sakamoto, A, Yanagisawa, M, Sakurai, T, Takuwa, Y, Yanagisawa, H, Masaki, T

“…We report the cloning of human cDNA encoding an ETB (non-isopeptide-selective) subtype of the endothelin receptor. The predicted amino acid sequence of the…”
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Delineation of genomic deletion in cardiomyopathic hamster by Sakamoto, Aiji, Abe, Makoto, Masaki, Tomoh

“…Cardiomyopathic hamster is a representative animal model for autosomal recessive cardiomyopathy. We have previously shown that the transcript of δ-sarcoglycan…”
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Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents by Ono, Kageyoshi, Tsujimoto, Gozoh, Sakamoto, Aiji, Eto, Koji, Masaki, Tomoh, Ozaki, Yukihiro, Satake, Motoyoshi

“…Voltage-sensitive ion channels play fundamental roles in the regulation of cardiac function by various neurotransmitters. Endothelins have strong positive…”
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Electrophysiological analysis of the negative chronotropic effect of endothelin-1 in rabbit sinoatrial node cells by Ono, Kageyoshi, Masumiya, Haruko, Sakamoto, Aiji, Christé, Georges, Shijuku, Toshinori, Tanaka, Hikaru, Shigenobu, Koki, Ozaki, Yukihiro

“…Electrophysiological effects of endothelin-1 (ET-1) were studied in rabbit sinoatrial node (SAN) using conventional microelectrode and whole-cell voltage and…”
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Morphological and Physiological Restorations of Hereditary Form of Dilated Cardiomyopathy by Somatic Gene Therapy by Kawada, Tomie, Sakamoto, Aiji, Nakazawa, Mikio, Urabe, Masashi, Masuda, Fujiko, Hemmi, Chieko, Wang, Yue, Soo Shin, Wee, Nakatsuru, Yoko, Sato, Hiroshi, Ozawa, Keiya, Toyo-oka, Teruhiko

“…TO-2 strain hamsters with dilated cardiomyopathy, gene deletion of δ-sarcoglycan (SG) and no expression of α-, β-, γ-, and δ-SG proteins are useful for…”
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Contribution of Sustained Ca Elevation for Nitric Oxide Production in Endothelial Cells and Subsequent Modulation of Ca Transient in Vascular Smooth Muscle Cells in Coculture by Yuepeng Wang, Wee Soo Shin, Hiroyuki Kawaguchi, Masao Inukai, Masayoshi Kato, Aiji Sakamoto, Yoshio Uehara, Miwa Miyamoto, Norio Shimamoto, Risa Korenaga, Joji Ando, Teruhiko Toyo-oka

“…To elucidate the intracellular Ca (Ca ) transient responsible for nitric oxide (NO) production in endothelial cells (ECs) and the subsequent Ca reduction in…”
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Long‐lasting activation of cation current by low concentration of endothelin‐1 in mouse fibroblasts and smooth muscle cells of rabbit aorta by Enoki, Taijiro, Miwa, Soichi, Sakamoto, Aiji, Minowa, Tetsuya, Komuro, Taro, Kobayashi, Shigeo, Ninomiya, Haruaki, Masaki, Tomoh

“…1 Recombinant human ETA receptors were expressed in a mouse fibroblast cell line (Ltk−cell) and functional coupling of the receptors with Ca2+ permeable…”
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Contribution of Sustained Ca2+ Elevation for Nitric Oxide Production in Endothelial Cells and Subsequent Modulation of Ca2+ Transient in Vascular Smooth Muscle Cells in Coculture (∗) by Wang, Yuepeng, Shin, Wee Soo, Kawaguchi, Hiroyuki, Inukai, Masao, Kato, Masayoshi, Sakamoto, Aiji, Uehara, Yoshio, Miyamoto, Miwa, Shimamoto, Norio, Korenaga, Risa, Ando, Joji, Toyo-oka, Teruhiko

“…To elucidate the intracellular Ca2+ (Ca2+i) transient responsible for nitric oxide (NO) production in endothelial cells (ECs) and the subsequent Ca2+i…”
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Desensitization of ETA endothelin receptor‐mediated negative chronotropic response in right atria–species difference and intracellular mechanisms by Ono, Kageyoshi, Sakamoto, Aiji, Masaki, Tomoh, Satake, Motoyoshi

“…1 Desensitization of ETA endothelin receptor (ETAR) was compared between the rat and guinea‐pig with regard to negative chronotropic response (NC) in the right…”
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Precise Identification of Gene Products in Hearts after in Vivo Gene Transfection, Using Sendai Virus-Coated Proteoliposomes by Kawada, Tomie, Shin, Wee Soo, Nakatsuru, Yoko, Koizumi, Toshiyuki, Sakamoto, Aiji, Nakajima, Toshiyuki, Okai-Matsuo, Yoko, Nakazawa, Mikio, Sato, Hiroshi, Ishikawa, Takatoshi, Toyo-Oka, Teruhiko

“…Both efficient gene transfer and the exact identification of gene product are required for gene therapy. Gene transfection of green fluorescence protein (GFP)…”
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Palmitoylation of Human EndothelinB by Okamoto, Yasuo, Ninomiya, Haruaki, Tanioka, Miki, Sakamoto, Aiji, Miwa, Soichi, Masaki, Tomoh

“…By site-directed mutagenesis, three cysteine residues (amino acids 402, 403, and 405) in the carboxyl terminus of human endothelinB (ETB) were identified as…”
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Structural Basis of G Protein Specificity of Human Endothelin Receptors by Takagi, Yasutaka, Ninomiya, Haruaki, Sakamoto, Aiji, Miwa, Soichi, Masaki, Tomoh

“…The endothelin (ET) family of peptides acts via two subtypes of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors termed ET A and ET…”
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Electrical and ionic abnormalities in the heart of cardiomyopathic hamsters: in quest of a new paradigm for cardiac failure and lethal arrhythmia by Sakamoto, Aiji

“…Cardiomyopathy is primary degenerative disease of myocardium, which leads to cardiac failure and lethal arrhythmia. An appropriate model animal of a particular…”
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