Search Results - "Sakakura, Tomoko"

Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment by Asahi, Yumiko, Nomura, Fumimasa, Abe, Yasuyuki, Doi, Masafumi, Sakakura, Tomoko, Takasuna, Kiyoshi, Yasuda, Kenji

“…Human ether-a-go-go-related gene (hERG) trafficking inhibition is known to be one of the mechanisms of indirect hERG inhibition, resulting in QT prolongation…”
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On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip by Kaneko, Tomoyuki, Nomura, Fumimasa, Hamada, Tomoyo, Abe, Yasuyuki, Takamori, Hideo, Sakakura, Tomoko, Takasuna, Kiyoshi, Sanbuissho, Atsushi, Hyllner, Johan, Sartipy, Peter, Yasuda, Kenji

“…To overcome the limitations and misjudgments of conventional prediction of arrhythmic cardiotoxicity, we have developed an on-chip in vitro predictive…”
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Availability of intracellular Ca2 + imaging using iPS-induced cardiomyocytes as a new cardiac toxicity assessment by Sakakura, Tomoko, Takasuna, Kiyoshi

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Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6) by Motoyama, Keisuke, Nagata, Tsutomu, Kobayashi, Jun, Nakamura, Akifumi, Miyoshi, Naoki, Kazui, Miho, Sakurai, Ken, Sakakura, Tomoko

“…[Display omitted] In this study, we aimed to synthesize a novel blocker of transient receptor potential canonical 6 (TRPC6). The sp2 carbon atoms of the…”
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Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor by Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki, Suzuki, Sayaka, Tanaka, Kyosuke, Karanjule, Narayan, Hayashi, Noriyuki, Tsuda, Toshifumi, Tokumaru, Eri, Inoue, Masahiro, Ueda, Kiyono, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Abe, Yasuyuki, Watanabe, Toshiyuki, Kitano, Yutaka

“…A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led…”
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N -Aryl Indoles as a Novel Class of Potent Na V 1.7 Inhibitors by Karanjule, Narayan, Hayashi, Noriyuki, Suzuki, Sayaka, Tsuda, Toshifumi, Tokumaru, Eri, Tanaka, Kyosuke, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Koishi, Ryuta, Fujiwara, Chie, Inaba, Shinichi, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Shinozuka, Tsuyoshi

“…A novel class of potent Na 1.7 inhibitors has been discovered. The replacement of diaryl ether in compound was investigated to enhance mouse Na 1.7 inhibitory…”
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N‑Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors by Karanjule, Narayan, Hayashi, Noriyuki, Suzuki, Sayaka, Tsuda, Toshifumi, Tokumaru, Eri, Tanaka, Kyosuke, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Koishi, Ryuta, Fujiwara, Chie, Inaba, Shinichi, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Shinozuka, Tsuyoshi

“…A novel class of potent NaV1.7 inhibitors has been discovered. The replacement of diaryl ether in compound I was investigated to enhance mouse NaV1.7…”
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Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor by Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki, Suzuki, Sayaka, Tanaka, Kyosuke, Karanjule, Narayan, Hayashi, Noriyuki, Tsuda, Toshifumi, Tokumaru, Eri, Inoue, Masahiro, Ueda, Kiyono, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Abe, Yasuyuki, Watanabe, Toshiyuki, Kitano, Yutaka

“…A highly potent, selective Na 1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives ( and ) led to…”
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Toward quasi-in vivo from in vitro assay (I): On-chip cardiomyocyte network screening assay for predictive cardiotoxicity by Yasuda, Kenji, Nomura, Fumimasa, Hamada, Tomoyo, Kaneko, Tomoyuki, Abe, Yasuyuki, Sakakura, Tomoko, Takasuna, Kiyoshi, Sanbuissho, Atsushi

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Evaluation of ion channel trafficking in human stem cell-derived cardiomyocytes for cardiotoxicity screening by Abe, Yasuyuki, Sakakura, Tomoko, Takasuna, Kiyoshi, Sanbuissho, Atsushi, Nomura, Fumimasa, Hamada, Tomoyo, Kaneko, Tomoyuki, Yasuda, Kenji

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Toward quasi-in vivo from in vitro assay (III): Evaluation of temporal field potential duration fluctuation and spatial conduction velocity fluctuation of cardiomyocyte network for in vitro predictive cardiotoxicity measurement by Hamada, Tomoyo, Nomura, Fumimasa, Kaneko, Tomoyuki, Takamori, Hideo, Abe, Yasuyuki, Sakakura, Tomoko, Takasuna, Kiyoshi, Sanbuissho, Atsushi, Yasuda, Kenji

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Application time—Dependent inhibition for hERG K + channel trafficking by Sakakura, Tomoko, Kitano, Yutaka, Chiba, Katsuyoshi, Takasuna, Kiyoshi, Sanbuissho, Atsushi

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Use and state dependent Nav1.5 blockers on QPatch X and in vivo assays by Jensen, M. Knirke, Sakakura, Tomoko, Abe, Yasuyuki, Takamori, Hideo, Takasuna, Kiyoshi, Tsurubuchi, Yuji, Sunesen, Morten

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Mostly Separate Distributions of CLAC- versus Aβ40- or Thioflavin S-Reactivities in Senile Plaques Reveal Two Distinct Subpopulations of β-Amyloid Deposits by Kowa, Hisatomo, Sakakura, Tomoko, Matsuura, Yusuke, Wakabayashi, Tomoko, Mann, David M.A., Duff, Karen, Tsuji, Shoji, Hashimoto, Tadafumi, Iwatsubo, Takeshi

“…Collagenous Alzheimer amyloid plaque component (CLAC) is a unique non-Aβ amyloid component of senile plaques (SP) derived from a transmembrane collagen termed…”
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Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits by Kowa, Hisatomo, Sakakura, Tomoko, Matsuura, Yusuke, Wakabayashi, Tomoko, Mann, David M A, Duff, Karen, Tsuji, Shoji, Hashimoto, Tadafumi, Iwatsubo, Takeshi

“…Collagenous Alzheimer amyloid plaque component (CLAC) is a unique non-Abeta amyloid component of senile plaques (SP) derived from a transmembrane collagen…”
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P1-235 CLAC-positive senile plaques in Alzheimer brains: mutually exclusive distribution to Aβ40 and acquisition of protease resistance by Kowa, Hisatomo, Sakakura, Tomoko, Matsuura, Yusuke, Wakabayashi, Tomoko, Tsuji, Shoji, Mann, David M., Hashimoto, Tadafumi, Iwatsubo, Takeshi

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Enhancement of Rectal Absorption of Ampicillin by Sodium Salicylate in Rabbits by NISHIHATA, TOSHIAKI, SAKAKURA, TOMOKO, HITOMI, MIRE, YAMAZAKI, MASARU, KAMADA, AKIRA

“…The enhancing action of sodium salicylate on rectal ampicillin absorption in rabbits showed a strong dependency on the concentration of sodium salicylate in…”
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Mostly Separate Distributions of CLAC- versus A{beta}40- or Thioflavin S-Reactivities in Senile Plaques Reveal Two Distinct Subpopulations of {beta}-Amyloid Deposits by Kowa, Hisatomo, Sakakura, Tomoko, Matsuura, Yusuke, Wakabayashi, Tomoko, Mann, David M.A, Duff, Karen, Tsuji, Shoji, Hashimoto, Tadafumi, Iwatsubo, Takeshi

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