Search Results - "Sakai, Takeru"

Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis by Goto, Toshihiro, Itoh, Michiko, Suganami, Takayoshi, Kanai, Sayaka, Shirakawa, Ibuki, Sakai, Takeru, Asakawa, Masahiro, Yoneyama, Toshihiro, Kai, Toshihiro, Ogawa, Yoshihiro

“…Accumulating evidence has suggested that farnesoid X receptor (FXR) agonists, such as obeticholic acid (OCA) are therapeutically useful for non-alcoholic…”
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Mapping the past with historical geographic information systems: layered characteristics of the historic urban landscape of Nanjing, China, since the Ming Dynasty (1368–2024) by Bai, Xuefeng, Jiao, Xinyu, Sakai, Takeru, Xu, Hao

“…The layering process of the historic urban landscape (HUL) has spatial and temporal characteristics. With the help of digital technology, building a database…”
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Public Perception of City Image Hotspots Based on Social Media: A Case Study of Nanjing, China by Bai, Xuefeng, Jiao, Xinyu, Zhang, Peiyuan, Sakai, Takeru, Xu, Hao

“…City image is an important element in the design of urban features. Big data from social media has become a new way to perceive city image characteristics…”
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Understanding the spatial pattern and structural characteristics of cities in late feudal China: evidence from the local chronicle maps of the qing dynasty (1644–1911) by Bai, Xuefeng, Jiao, Xinyu, Jiang, Wencheng, Sakai, Takeru, Xu, Hao

“…Our study analyzes the spatial pattern and structural characteristics of cities in late feudal China based on multiple correlation and geographic information…”
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Time in range correlates glycated albumin measured immediately after 2 weeks of continuous glucose monitoring by Sakai, Takeru, Aoyama, Kazuki, Inazumi, Koji, Kikuchi, Rieko, Sato, Yuki, Tada, Ai, Hirata, Takumi, Morimoto, Jiro

“…Time in range (TIR), an index of glycemic control and also blood glucose fluctuation, obtained from continuous glucose monitoring (CGM), has been increasing…”
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Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis by Ebihara, Chihiro, Ebihara, Ken, Aizawa-Abe, Megumi, Mashimo, Tomoji, Tomita, Tsutomu, Zhao, Mingming, Gumbilai, Valentino, Kusakabe, Toru, Yamamoto, Yuji, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Hosoda, Kiminori, Serikawa, Tadao, Nakao, Kazuwa

“…Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital…”
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Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis by Asakawa, Masahiro, Itoh, Michiko, Suganami, Takayoshi, Sakai, Takeru, Kanai, Sayaka, Shirakawa, Ibuki, Yuan, Xunmei, Hatayama, Tomomi, Shimada, Shu, Akiyama, Yoshimitsu, Fujiu, Katsuhito, Inagaki, Yutaka, Manabe, Ichiro, Yamaoka, Shoji, Yamada, Tetsuya, Tanaka, Shinji, Ogawa, Yoshihiro

“…Non-alcoholic steatohepatitis (NASH), characterized by chronic inflammation and fibrosis, is predicted to be the leading cause of cirrhosis and hepatocellular…”
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CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis by Itoh, Michiko, Suganami, Takayoshi, Kato, Hideaki, Kanai, Sayaka, Shirakawa, Ibuki, Sakai, Takeru, Goto, Toshihiro, Asakawa, Masahiro, Hidaka, Isao, Sakugawa, Hiroshi, Ohnishi, Koji, Komohara, Yoshihiro, Asano, Kenichi, Sakaida, Isao, Tanaka, Masato, Ogawa, Yoshihiro

“…Although recent evidence has pointed to the role of organ- and pathogenesis-specific macrophage subsets, it is still unclear which subsets are critically…”
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Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using melanocortin 4 receptor-deficient mice by Konuma, Kuniha, Itoh, Michiko, Suganami, Takayoshi, Kanai, Sayaka, Nakagawa, Nobutaka, Sakai, Takeru, Kawano, Hiroyuki, Hara, Mitsuko, Kojima, Soichi, Izumi, Yuichi, Ogawa, Yoshihiro

“…Many attempts have been made to find novel therapeutic strategies for non-alcoholic steatohepatitis (NASH), while their clinical efficacy is unclear. We have…”
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DISASTER CONSEQUENCE MITIGATION AND EVALUATION OF ROADSIDE GREEN SPACES IN NANJING by Fei, Wenjun, Jin, Zhijia, Ye, Jienan, Divigalpitiya, Prasanna, Sakai, Takeru, Wang, Chengkang

“…The extensive layout of roadside green spaces make them important green disaster mitigation nodes in high-density areas of any city; hence, further…”
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Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice by Kusakabe, Toru, Ebihara, Ken, Sakai, Takeru, Miyamoto, Licht, Aotani, Daisuke, Yamamoto, Yuji, Yamamoto-Kataoka, Sachiko, Aizawa-Abe, Megumi, Fujikura, Junji, Hosoda, Kiminori, Nakao, Kazuwa

“…Leptin enhances insulin sensitivity in addition to reducing food intake and body weight. Recently, amylin, a pancreatic β-cell-derived hormone, was shown to…”
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Leptin Activates Hepatic 5′-AMP-activated Protein Kinase through Sympathetic Nervous System and α1-Adrenergic Receptor by Miyamoto, Licht, Ebihara, Ken, Kusakabe, Toru, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Aizawa-Abe, Megumi, Yamamoto, Yuji, Fujikura, Junji, Hayashi, Tatsuya, Hosoda, Kiminori, Nakao, Kazuwa

“…Leptin is an adipocyte-derived hormone that regulates energy homeostasis. Leptin treatment strikingly ameliorates metabolic disorders of lipodystrophy, which…”
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Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver by Aizawa-Abe, Megumi, Ebihara, Ken, Ebihara, Chihiro, Mashimo, Tomoji, Takizawa, Akiko, Tomita, Tsutomu, Kusakabe, Toru, Yamamoto, Yuji, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Hosoda, Kiminori, Serikawa, Tadao, Nakao, Kazuwa

“…Leptin is one of the key molecules in maintaining energy homeostasis. Although genetically leptin-deficient Lep(ob)/Lep(ob) mice have greatly contributed to…”
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Construction, assessment, and protection of green infrastructure networks from a dynamic perspective: A case study of Dalian City, Liaoning Province, China by Lyu, Liang, Sho, Kojiro, Zhao, Han, Song, Youngkeun, Uchiyama, Yuta, Kim, Jihwan, Sakai, Takeru

“…The green infrastructure (GI) network, an important nature-based solution (NBS) strategy, is pivotal for sustainable urban development. However, current…”
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Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and α1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin by Miyamoto, Licht, Ebihara, Ken, Kusakabe, Toru, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Aizawa-Abe, Megumi, Yamamoto, Yuji, Fujikura, Junji, Hayashi, Tatsuya, Hosoda, Kiminori, Nakao, Kazuwa

“…AMPK activation promotes glucose and lipid metabolism. Hepatic AMPK activities were decreased in fatty liver from lipodystrophic mice, and leptin activated the…”
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Functional Magnetic Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy Undergoing Leptin Replacement Therapy by Aotani, Daisuke, Ebihara, Ken, Sawamoto, Nobukatsu, Kusakabe, Toru, Aizawa-Abe, Megumi, Kataoka, Sachiko, Sakai, Takeru, Iogawa, Hitomi, Ebihara, Chihiro, Fujikura, Junji, Hosoda, Kiminori, Fukuyama, Hidenao, Nakao, Kazuwa

“…Context: Lipodystrophy is a disease characterized by a paucity of adipose tissue and low circulating concentrations of adipocyte-derived leptin…”
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Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet by Sakai, Takeru, Kusakabe, Toru, Ebihara, Ken, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Zhao, Mingming, Gumbilai, Valentino Milton Junior, Ebihara, Chihiro, Aizawa-Abe, Megumi, Yamamoto, Yuji, Noguchi, Michio, Fujikura, Junji, Hosoda, Kiminori, Inagaki, Nobuya, Nakao, Kazuwa

“…Leptin may reduce pancreatic lipid deposition, which increases with progression of obesity and can impair β-cell function. The insulinotropic effect of…”
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Generation of leptin-deficient Lep super(mkyo)/Lep super(mkyo) rats and identification of leptin-responsive genes in the liver by Aizawa-Abe, Megumi, Ebihara, Ken, Ebihara, Chihiro, Mashimo, Tomoji, Takizawa, Akiko, Tomita, Tsutomu, Kusakabe, Toru, Yamamoto, Yuji, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Hosoda, Kiminori, Serikawa, Tadao, Nakao, Kazuwa

“…Leptin is one of the key molecules in maintaining energy homeostasis. Although genetically leptin-deficient Lep super(ob)/Lep super(ob) mice have greatly…”
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Generation of leptin-deficient Lep mkyo /Lep mkyo rats and identification of leptin-responsive genes in the liver by Aizawa-Abe, Megumi, Ebihara, Ken, Ebihara, Chihiro, Mashimo, Tomoji, Takizawa, Akiko, Tomita, Tsutomu, Kusakabe, Toru, Yamamoto, Yuji, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Hosoda, Kiminori, Serikawa, Tadao, Nakao, Kazuwa

“…Leptin is one of the key molecules in maintaining energy homeostasis. Although genetically leptin-deficient Lep ob /Lep ob mice have greatly contributed to…”
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