Acute Moderate-Intensity Exercise Induces Vasodilation Through an Increase in Nitric Oxide Bioavailiability in Humans

Long-term moderate-intensity exercise augments endothelium-dependent vasodilation through an increase in nitric oxide (NO) production. The purpose of this study was to determine the effects of different intensities of acute exercise on hemodynamics in humans. We evaluated forearm blood flow (FBF) re...

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Published in:	American journal of hypertension Vol. 20; no. 8; pp. 825 - 830
Main Authors:	Goto, Chikara, Nishioka, Kenji, Umemura, Takashi, Jitsuiki, Daisuke, Sakagutchi, Akihiro, Kawamura, Mitsutoshi, Chayama, Kazuaki, Yoshizumi, Masao, Higashi, Yukihito
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-08-2007 Oxford University Press Elsevier Science
Subjects:	8-isoprostane Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood Flow Velocity - physiology Blood Pressure - physiology Blood vessels and receptors Cardiology. Vascular system Dinoprost - analogs & derivatives Dinoprost - blood Enzyme-Linked Immunosorbent Assay Exercise Exercise - physiology Exercise Test Exercise Tolerance - physiology Experimental diseases Forearm - blood supply forearm blood flow Fundamental and applied biological sciences. Psychology Heart Rate - physiology Humans Male Medical sciences nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - blood Norepinephrine - blood Oxidative Stress - physiology Oxygen Consumption - physiology Plethysmography Reference Values Vascular Resistance - physiology Vasodilation - physiology Vertebrates: cardiovascular system nitric oxide Exercise 8-isoprostane forearm blood flow Physical exercise Human Hypertension Nitric oxide Cardiovascular disease Vasodilation Blood flow
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Summary:	Long-term moderate-intensity exercise augments endothelium-dependent vasodilation through an increase in nitric oxide (NO) production. The purpose of this study was to determine the effects of different intensities of acute exercise on hemodynamics in humans. We evaluated forearm blood flow (FBF) responses to different intensities of exercise (mild, 25% maximum oxygen consumption [V̇ o 2max]; moderate, 50% V̇ o 2max; and high, 75% V̇ o 2max; bicycle ergometer, for 30 min) in eight healthy young men. The FBF was measured by using a strain–gauge plethysmography. After exercise began, moderate-intensity exercise, but not mild-intensity exercise, promptly increased FBF from 2.8 ± 1.1 mL/min/100 mL to a plateau at 5.4 ± 1.6 mL/min/100 mL at 5 min ( P < .01) and increased mean arterial pressure from 84.7 ± 11.8 mm Hg to a plateau at 125.7 ± 14.3 mm Hg at 5 min ( P < .01). Moderate-intensity exercise decreased forearm vascular resistance (FVR) from 29.2 ± 5.4 to 16.8 ± 3.2 mm Hg/mL/min/100 mL tissue ( P < .01). The administration of N G-monomethyl- l-arginine, an NO synthase inhibitor, abolished moderate exercise–induced augmentation of vasodilation. Although we were not able to measure FBF during high-intensity exercise because of large body motion, high-intensity exercise markedly increased mean arterial pressure from 82.6 ± 12.2 to 146.8 ± 19.8 mm Hg. High-intensity exercise, but not mild-intensity or moderate-intensity exercise, increased plasma concentration of 8-isoprostane, an index of oxidative stress, from 24.1 ± 10.8 to 40.2 ± 16.7 pg/mL ( P < .05) at 10 min after the end of exercise. These findings suggest that acute moderate-intensity exercise induces vasodilation through an increase in NO bioavailability in humans and that high-intensity exercise increases oxidative stress.
Bibliography:	istex:57FC9CB89120D093607151F72D6FC94B0A82089C ark:/67375/HXZ-F1XW8GV9-3 This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan. href:20_8_825.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0895-7061 1879-1905 1941-7225
DOI:	10.1016/j.amjhyper.2007.02.014