Search Results - "Sakaguchi, Takuya F."

Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy by Davuluri, Gangarao, Song, Ping, Liu, Zhuoming, Wald, David, Sakaguchi, Takuya F., Green, Michael R., Devireddy, L.

“…Mitochondria are the site of iron utilization, wherein imported iron is incorporated into heme or iron–sulfur clusters. Previously, we showed that a cytosolic…”
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Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation by Lord, Caleb C., Ferguson, Daniel, Thomas, Gwynneth, Brown, Amanda L., Schugar, Rebecca C., Burrows, Amy, Gromovsky, Anthony D., Betters, Jenna, Neumann, Chase, Sacks, Jessica, Marshall, Stephanie, Watts, Russell, Schweiger, Martina, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Lathia, Justin D., Sakaguchi, Takuya F., Lehner, Richard, Haemmerle, Guenter, Zechner, Rudolf, Brown, J. Mark

“…Adipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought…”
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NCK-associated protein 1 like (nckap1l) minor splice variant regulates intrahepatic biliary network morphogenesis by Ghaffari, Kimia, Pierce, Lain X, Roufaeil, Maria, Gibson, Isabel, Tae, Kevin, Sahoo, Saswat, Cantrell, James R, Andersson, Olov, Lau, Jasmine, Sakaguchi, Takuya F

“…Impaired formation of the intrahepatic biliary network leads to cholestatic liver diseases, which are frequently associated with autoimmune disorders. Using a…”
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Endothelial Signals Modulate Hepatocyte Apicobasal Polarization in Zebrafish by Sakaguchi, Takuya F., Sadler, Kirsten C., Crosnier, Cecile, Stainier, Didier Y.R.

“…Emerging evidence indicates that paracrine signals from endothelial cells play a role in tissue differentiation and organ formation [1–3]. Here, we identify a…”
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Forward genetics combined with unsupervised classifications identified zebrafish mutants affecting biliary system formation by Singh, Divya Jyoti, Tuscano, Kathryn M., Ortega, Amrhen L., Dimri, Manali, Tae, Kevin, Lee, William, Muslim, Muslim A., Rivera Paz, Isabela M., Liu, Jay L., Pierce, Lain X., McClendon, Allyson, Gibson, Isabel, Livesay, Jodi, Sakaguchi, Takuya F.

“…Impaired formation of the biliary network can lead to congenital cholestatic liver diseases; however, the genes responsible for proper biliary system formation…”
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Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans by DeRossi, Charles, Bambino, Kathryn, Morrison, Joshua, Sakarin, Isabel, Villacorta‐Martin, Carlos, Zhang, Changwen, Ellis, Jillian L., Fiel, M. Isabel, Ybanez, Maria, Lee, Youngmin A., Huang, Kuan‐lin, Yin, Chunyue, Sakaguchi, Takuya F., Friedman, Scott L., Villanueva, Augusto, Chu, Jaime

“…The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model…”
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Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish by Dimri, Manali, Bilogan, Cassandra, Pierce, Lain X, Naegele, Gregory, Vasanji, Amit, Gibson, Isabel, McClendon, Allyson, Tae, Kevin, Sakaguchi, Takuya F

“…The intrahepatic biliary network is a highly branched three-dimensional network lined by biliary epithelial cells, but how its branching patterns are precisely…”
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The Role of P35/Cdk5-Mediated Kinase Cascade in Intrahepatic Biliary Morphogenesis in Zebrafish, and its Application in Human Biliary Research by Moslim, Maitham A, Dimri, Manali, Morris-Stiff, Gareth, Walsh, R. Matthew, Sakaguchi, Takuya F

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Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish by Dimri, Manali, Bilogan, Cassandra, Pierce, Lain X., Naegele, Gregory, Vasanji, Amit, Gibson, Isabel, McClendon, Allyson, Tae, Kevin, Sakaguchi, Takuya F.

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Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis by Nussbaum, Justin M., Liu, Liuhong J., Hasan, Syeda A., Schaub, Madeline, McClendon, Allyson, Stainier, Didier Y.R., Sakaguchi, Takuya F.

“…Nonalcoholic fatty liver disease is the most common liver disease in both adults and children. The earliest stage of this disease is hepatic steatosis, in…”
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Mutation of zebrafish Snapc4 is associated with loss of the intrahepatic biliary network by Schaub, Madeline, Nussbaum, Justin, Verkade, Heather, Ober, Elke A., Stainier, Didier Y.R., Sakaguchi, Takuya F.

“…Biliary epithelial cells line the intrahepatic biliary network, a complex three-dimensional network of conduits. The loss of differentiated biliary epithelial…”
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1137 – Forward Genetics Identifies Host Locus Responsible for Dysbiotic Phenotype Shift in the Gut Microbiota by Rodriguez-Palacios, Alexander, Sakaguchi, Takuya F.

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Homeostatic Generation of Reactive Oxygen Species Protects Liver from Hepatic Steatosis in Zebrafish by Sakaguchi, Takuya F.

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NCK-associated protein 1 like by Ghaffari, Kimia, Pierce, Lain X, Roufaeil, Maria, Gibson, Isabel, Tae, Kevin, Sahoo, Saswat, Cantrell, James R, Andersson, Olov, Lau, Jasmine, Sakaguchi, Takuya F

“…Impaired formation of the intrahepatic biliary network leads to cholestatic liver diseases, which are frequently associated with autoimmune disorders. Using a…”
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1030 - The Role of P35/Cdk5-Mediated Kinase Cascade in Intrahepatic Biliary Morphogenesis in Zebrafish, and its Application in Human Biliary Research by Moslim, Maitham A., Dimri, Manali, Morris-Stiff, Gareth, Walsh, R. Matthew, Sakaguchi, Takuya F.

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Endothelial signals regulate hepatocyte apico-basal polarization in zebrafish by Sakaguchi, Takuya F., Sadler, Kirsten C., Crosnier, Cecile, Stainier, Didier Y.

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CGI-58’S ABILITY TO REGULATE HEPATIC TRIACYLGLYCEROL METABOLISM DOES NOT REQUIRE ATGL CO-ACTIVATION by Lord, Caleb C., Ferguson, Daniel, Thomas, Gwynneth, Brown, Amanda L., Schugar, Rebecca C., Burrows, Amy, Gromovsky, Anthony D., Betters, Jenna, Neumann, Chase, Sacks, Jessica, Marshall, Stephanie, Watts, Russell, Schweiger, Martina, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Lathia, Justin D., Sakaguchi, Takuya F., Lehner, Richard, Haemmerle, Guenter, Zechner, Rudolf, Brown, J. Mark

“…Adipose Triglyceride Lipase (ATGL) and Comparative Gene Identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought…”
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