Search Results - "Sakaguchi, Aisa"
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REI-1 Is a Guanine Nucleotide Exchange Factor Regulating RAB-11 Localization and Function in C. elegans Embryos
Published in Developmental cell (26-10-2015)“…The small GTPase Rab11 dynamically changes its location to regulate various cellular processes such as endocytic recycling, secretion, and cytokinesis…”
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Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants
Published in Cell reports (Cambridge) (01-05-2014)“…Defects in the Piwi/piRNA pathway lead to transposon desilencing and immediate sterility in many organisms. We found that the C. elegans Piwi mutant prg-1…”
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Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations
Published in Proceedings of the National Academy of Sciences - PNAS (14-10-2014)“…Significance Here, we establish a role for small RNAs in promoting transgenerational fertility via an endogenous temperature-sensitive silencing process that…”
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REI-1, a Novel Rab11 GEF with a SH3BP5 domain
Published in Communicative & integrative biology (02-09-2016)“…The small GTPase Rab proteins are key regulators of membrane trafficking. Rab11 is one of the best-characterized molecules among the Rab family proteins and it…”
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Roles of MAP Kinase Cascades in Caenorhabditis elegans
Published in Journal of biochemistry (Tokyo) (01-07-2004)“…Mitogen-activated protein kinases (MAPKs) are serine/threonine protein kinases that are activated by diverse stimuli such as growth factors, cytokines,…”
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LRK-1, a C. elegans PARK8-Related Kinase, Regulates Axonal-Dendritic Polarity of SV Proteins
Published in Current biology (03-04-2007)“…Neurons are polarized cells that contain distinct sets of proteins in their axons and dendrites. Synaptic vesicles (SV) and many SV proteins are exclusively…”
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REI/SH3BP5 protein family: New GEFs for Rab11
Published in Cell cycle (Georgetown, Tex.) (18-03-2016)Get full text
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piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
Published in Cell (06-07-2012)“…Transgenerational effects have wide-ranging implications for human health, biological adaptation, and evolution; however, their mechanisms and biology remain…”
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