Search Results - "Sakagami, Yasuko"

Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137) by SHIMURA, Kazuya, KODAMA, Eiichi, KANO, Mitsuki, IKEDA, Satoru, MATSUOKA, Masao, SAKAGAMI, Yasuko, MATSUZAKI, Yuji, WATANABE, Wataru, YAMATAKA, Kazunobu, WATANABE, Yasuo, OHATA, Yoshitsugu, DOI, Satoki, SATO, Motohide

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SC29EK, a Peptide Fusion Inhibitor with Enhanced α-Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide by NAITO, Takeshi, IZUMI, Kazuki, MATSUOKA, Masao, KODAMA, Eiichi, SAKAGAMI, Yasuko, KAJIWARA, Keiko, NISHIKAWA, Hiroki, WATANABE, Kentaro, SARAFIANOS, Stefan G, OISHI, Shinya, FUJII, Nobutaka

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Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors by Hachiya, Atsuko, Kodama, Eiichi N, Sarafianos, Stefan G, Schuckmann, Matthew M, Sakagami, Yasuko, Matsuoka, Masao, Takiguchi, Masafumi, Gatanaga, Hiroyuki, Oka, Shinichi

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Resistance Profiles of Novel Electrostatically Constrained HIV-1 Fusion Inhibitors by Shimura, Kazuya, Nameki, Daisuke, Kajiwara, Keiko, Watanabe, Kentaro, Sakagami, Yasuko, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao, Sarafianos, Stefan G., Kodama, Eiichi N.

“…Human immunodeficiency virus (HIV) gp41 plays a key role in viral fusion; the N- and C-terminal heptad repeats (N-HR and C-HR) of gp41 form a stable 6-helical…”
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Design of Peptide-based Inhibitors for Human Immunodeficiency Virus Type 1 Strains Resistant to T-20 by Izumi, Kazuki, Kodama, Eiichi, Shimura, Kazuya, Sakagami, Yasuko, Watanabe, Kentaro, Ito, Saori, Watabe, Tsuyoshi, Terakawa, Yukihiro, Nishikawa, Hiroki, Sarafianos, Stefan G., Kitaura, Kazuo, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao

“…Enfuvirtide (T-20) is a fusion inhibitor that suppresses replication of human immunodeficiency virus (HIV) variants with multi-drug resistance to reverse…”
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K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism by Hachiya, Atsuko, Kodama, Eiichi N, Schuckmann, Matthew M, Kirby, Karen A, Michailidis, Eleftherios, Sakagami, Yasuko, Oka, Shinichi, Singh, Kamalendra, Sarafianos, Stefan G

“…HIV-1 carrying the "Q151M complex" reverse transcriptase (RT) mutations (A62V/V75I/F77L/F116Y/Q151M, or Q151Mc) is resistant to many FDA-approved nucleoside RT…”
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HIV-1 Resistance Mechanism to an Electrostatically Constrained Peptide Fusion Inhibitor That Is Active against T-20-Resistant Strains by SHIMANE, Kazuki, KAWAJI, Kumi, SARAFIANOS, Stefan G, KODAMA, Eiichi N, MIYAMOTO, Fusako, OISHI, Shinya, WATANABE, Kentaro, SAKAGAMI, Yasuko, FUJII, Nobutaka, SHIMURA, Kazuya, MATSUOKA, Masao, KAKU, Mitsuo

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Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design by Izumi, Kazuki, Kawaji, Kumi, Miyamoto, Fusasko, Shimane, Kazuki, Shimura, Kazuya, Sakagami, Yasuko, Hattori, Toshio, Watanabe, Kentaro, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao, Kaku, Mitsuo, Sarafianos, Stefan G., Kodama, Eiichi N.

“…► T-20S138A, a resistance mutation introduced peptide, blocks T20-resistant HIV-1. ► To determine how HIV-1 escapes, we induced T-20S138A-resistant HIV-1 in…”
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Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients by Hachiya, Atsuko, Shimane, Kazuki, Sarafianos, Stefan G., Kodama, Eiichi N., Sakagami, Yasuko, Negishi, Fujie, Koizumi, Hirokazu, Gatanaga, Hiroyuki, Matsuoka, Masao, Takiguchi, Masafumi, Oka, Shinichi

“…Some mutations in the connection subdomain of the polymerase domain and in the RNase H domain of HIV-1 reverse transcriptase (RT) have been shown to contribute…”
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Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat by Izumi, Kazuki, Nakamura, Shota, Nakano, Hiroaki, Shimura, Kazuya, Sakagami, Yasuko, Oishi, Shinya, Uchiyama, Susumu, Ohkubo, Tadayasu, Kobayashi, Yuji, Fujii, Nobutaka, Matsuoka, Masao, Kodama, Eiichi N.

“…A transmembrane glycoprotein of HIV-1, gp41, plays a central role in membrane fusion of HIV-1 and host cells. Peptides derived from the amino- and…”
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Dual-Reporter Phenotypic Assay for Human Immunodeficiency Viruses by Kajiwara, Keiko, Kodama, Eiichi, Sakagami, Yasuko, Naito, Takeshi, Matsuoka, Masao

“…We have established a novel human immunodeficiency virus (HIV) tandem-reporter assay using HIV receptor-transduced NP-2 cells with long terminal…”
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2′-Deoxy-4′- C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants by Kawamoto, Atsushi, Kodama, Eiichi, Sarafianos, Stefan G., Sakagami, Yasuko, Kohgo, Satoru, Kitano, Kenji, Ashida, Noriyuki, Iwai, Yuko, Hayakawa, Hiroyuki, Nakata, Hirotomo, Mitsuya, Hiroaki, Arnold, Eddy, Matsuoka, Masao

“…One of the formidable challenges in therapy of infections by human immunodeficiency virus (HIV) is the emergence of drug-resistant variants that attenuate the…”
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Design of a Novel HIV-1 Fusion Inhibitor That Displays a Minimal Interface for Binding Affinity by Oishi, Shinya, Ito, Saori, Nishikawa, Hiroki, Watanabe, Kentaro, Tanaka, Michinori, Ohno, Hiroaki, Izumi, Kazuki, Sakagami, Yasuko, Kodama, Eiichi, Matsuoka, Masao, Fujii, Nobutaka

“…Reported herein are the design, biological activities, and biophysical properties of a novel HIV-1 membrane fusion inhibitor. α-Helix-inducible X-EE-XX-KK…”
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Electrostatically constrained α-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide by Nishikawa, Hiroki, Nakamura, Shota, Kodama, Eiichi, Ito, Saori, Kajiwara, Keiko, Izumi, Kazuki, Sakagami, Yasuko, Oishi, Shinya, Ohkubo, Tadayasu, Kobayashi, Yuji, Otaka, Akira, Fujii, Nobutaka, Matsuoka, Masao

“…α-Helical peptides, such as T-20 (enfuvirtide) and C34, derived from the gp41 carboxyl-terminal heptad repeat (C-HR) of HIV-1, inhibit membrane fusion of HIV-1…”
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Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4 by Shimane, Kazuki, Kodama, Eiichi N., Nakase, Ikuhiko, Futaki, Shiroh, Sakurai, Yasuteru, Sakagami, Yasuko, Li, Xiaoguang, Hattori, Toshio, Sarafianos, Stefan G., Matsuoka, Masao

“…Rev, a viral regulatory protein of HIV-1, binds through its arginine-rich domain to the Rev-responsive element (RRE), a secondary structure in transcribed…”
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Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide by Ueno, Mariko, Kodama, Eiichi N., Shimura, Kazuya, Sakurai, Yasuteru, Kajiwara, Keiko, Sakagami, Yasuko, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao

“…Primary mutations in HIV-1 that are directly involved in the resistance to enfuvirtide have been well documented. However, secondary mutations that are…”
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SC29EK, a Peptide Fusion Inhibitor with Enhanced -Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide by Naito, Takeshi, Izumi, Kazuki, Kodama, Eiichi, Sakagami, Yasuko, Kajiwara, Keiko, Nishikawa, Hiroki, Watanabe, Kentaro, Sarafianos, Stefan G, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao

“…Peptides derived from the -helical domains of human immunodeficiency virus (HIV) type 1 (HIV-1) gp41 inhibit HIV-1 fusion to the cell membrane. Enfuvirtide…”
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Design of Peptide-based Inhibitors for Human Immunodeficiency Virus Type 1 Strains Resistant to T-20S by Izumi, Kazuki, Kodama, Eiichi, Shimura, Kazuya, Sakagami, Yasuko, Watanabe, Kentaro, Ito, Saori, Watabe, Tsuyoshi, Terakawa, Yukihiro, Nishikawa, Hiroki, Sarafianos, Stefan G., Kitaura, Kazuo, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao

“…Enfuvirtide (T-20) is a fusion inhibitor that suppresses replication of human immunodeficiency virus (HIV) variants with multi-drug resistance to reverse…”
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Amino Acid Mutation N3481 in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors by HACHIYA, Atsuko, KODAMA, Eiichi N, SARAFIANOS, Stefan G, SCHUCKMANN, Matthew M, SAKAGAMI, Yasuko, MATSUOKA, Masao, TAKIGUCHI, Masafumi, GATANAGA, Hiroyuki, OKA, Shinichi

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Clinical relevance of substitutions in the connection subdomain and RNase H domains of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients by Hachiya, Atsuko, Shimane, Kazuki, Sarafianos, Stefan G., Kodama, Eiichi N., Sakagami, Yasuko, Negishi, Fujie, Koizumi, Hirokazu, Gatanaga, Hiroyuki, Matsuoka, Masao, Takiguchi, Masafumi, Oka, Shinichi

“…Some mutations in the connection subdomain of the polymerase domain and in the RNase H domain of HIV-1 reverse transcriptase (RT) have been shown to contribute…”
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