Search Results - "Sakae Arimoto-Kobayashi"

Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice by Takata, Jun, Kiura, Katsuyuki, Nakasuka, Takamasa, Hirabae, Atsuko, Arimoto-Kobayashi, Sakae

“…We investigated the chemopreventive effects of beer, nonalcoholic beers (NABs), and beer-components (glycine betaine (GB)) on NNK-induced lung tumorigenesis in…”
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Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan by Arimoto-Kobayashi, Sakae, Hida, Ryoko, Fujii, Nana, Mochioka, Ryosuke

“…Mutation, inflammation, and oxidative damage including lipid-peroxidation are factors involved in the development of cancer. We investigated the antimutagenic,…”
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Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse by Takata, Jun, Miyake, Naoko, Saiki, Yusuke, Tada, Misako, Sasaki, Kensuke, Kubo, Toshio, Kiura, Katsuyuki, Arimoto-Kobayashi, Sakae

“…Previously, we reported the inhibitory effect of Actinidia arguta juice, known as sarunashi juice (sar-j) in Japan, on mutagenesis, inflammation, and mouse…”
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Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice by Kitamura, Yuki, Sakanashi, Mayuko, Ozawa, Azuki, Saeki, Yuri, Nakamura, Ayano, Hara, Yuiho, Saeki, Ken-ichi, Arimoto-Kobayashi, Sakae

“…Parkinson’s disease (PD) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra…”
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Elimination of mutagenic contaminants from water using cellulose bearing ferrous-phthalocyanine by Sano, Kayoko, Soga, Yuka, Ohta, Kaori, Kitamura, Yuki, Arimoto-Kobayashi, Sakae

“…We previously investigated methods for separating mutagenic contaminants from aqueous solutions using cellulose-bearing covalently bound…”
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2,6-Dimethoxy-1,4-benzoquinone, isolation and identification of anti-carcinogenic, anti-mutagenic and anti-inflammatory component from the juice of Vitis coignetiae by Kamiya, Tomonori, Tanimoto, Yusuke, Fujii, Nana, Negishi, Tomoe, Suzuki, Toshinori, Hatano, Tsutomu, Arimoto-Kobayashi, Sakae

“…Previously we demonstrated the anti-tumorigenic, anti-mutagenic and anti-inflammatory effects of the juice of Vitis coignetiae (yamabudo), and identified…”
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Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice by Arimoto-Kobayashi, Sakae, Sasaki, Kensuke, Hida, Ryoko, Miyake, Naoko, Fujii, Nana, Saiki, Yusuke, Daimaru, Kyohei, Nakashima, Hirono, Kubo, Toshio, Kiura, Katsuyuki

“…Previously, we isolated and identified anti-mutagenic and anti-inflammatory components from Vitis coignetiae (crimson glory vine, known as yamabudo in Japan)…”
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Photomicronucleus assay of phototoxic and pseudophotoclastogenic chemicals in human keratinocyte NCTC2544 cells by Horinouchi, Mayumi, Arimoto-Kobayashi, Sakae

“…Photochemical genotoxicity was evaluated in human keratinocyte NCTC2544 cells. The cells were pre-treated with photogenotoxic or pseudophotoclastogenic…”
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RXR Partial Agonist Produced by Side Chain Repositioning of Alkoxy RXR Full Agonist Retains Antitype 2 Diabetes Activity without the Adverse Effects by Kawata, Kohei, Morishita, Ken-ichi, Nakayama, Mariko, Yamada, Shoya, Kobayashi, Toshiki, Furusawa, Yuki, Arimoto-Kobayashi, Sakae, Oohashi, Toshitaka, Makishima, Makoto, Naitou, Hirotaka, Ishitsubo, Erika, Tokiwa, Hiroaki, Tai, Akihiro, Kakuta, Hiroki

“…We previously reported RXR partial agonist CBt-PMN (1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid: 5, EC50 = 143…”
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Inhibitory Effects of Beer on Mutation in the Ames Test and DNA Adduct Formation in Mouse Organs Induced by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Arimoto-Kobayashi, Sakae, Ishida, Rie, Nakai, Yumi, Idei, Chiho, Takata, Jun, Takahashi, Eizo, Okamoto, Keinosuke, Negishi, Tomoe, Konuma, Toshimitsu

“…An evaluation of the antigenotoxic potential of beer components against carcinogens contained in the human diet, namely heterocyclic amines (HCAs) including…”
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Increase of somatic cell mutations in oxidative damage-sensitive drosophila by Koike, Ryota, Uchiyama, Tomoyo, Arimoto-Kobayashi, Sakae, Okamoto, Keinosuke, Negishi, Tomoe

“…Oxidative damage is an important genotoxic source for almost all organisms. To efficiently detect mutations induced by oxidative damage, we previously…”
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Somatic-cell mutation induced by short exposures to cigarette smoke in urate-null, oxidative stress-sensitive Drosophila by Uchiyama, Tomoyo, Koike, Ryota, Yuma, Yoko, Okamoto, Keinosuke, Arimoto-Kobayashi, Sakae, Suzuki, Toshinori, Negishi, Tomoe

“…We previously reported that a urate-null strain of Drosophila is hypersensitive to cigarette smoke (CS), and we suggested that CS induces oxidative stress in…”
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Inhibitory effect of Actinidia arguta on mutagenesis, inflammation and two-stage mouse skin tumorigenesis by Nishimura, Mari, Okimasu, Yuma, Miyake, Naoko, Tada, Misako, Hida, Ryoko, Negishi, Tomoe, Arimoto-Kobayashi, Sakae

“…, known as sarunashi in Japan, is a vine tree native to east-Asia, including Japan, that produces small fruit rich in anthocyanins, catechins, vitamin C,…”
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Anti-genotoxic activity of Vitis coignetiae Pulliat towards heterocyclic amines and isolation and identification of caftaric acid as an antimutagenic component from the juice by Zhang, Xiaomeng, Ishida, Rie, Yuhara, Yuta, Kamiya, Tomonori, Hatano, Tsutomu, Okamoto, Goro, Arimoto-Kobayashi, Sakae

“…Our study demonstrated that the formation of DNA adducts in liver, lungs, colon and kidneys of mice given a carcinogenic heterocyclic amine,…”
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Near ultraviolet radiation-mediated reaction between N-nitrosoproline and DNA: Isolation and identification of two new adducts, (R)- and (S)-8-(2-pyrrolidyl)-2′-deoxyguanosine by Aoyama, Shuhei, Sano, Kayoko, Asahi, Chiharu, Machida, Masaki, Okamoto, Keinosuke, Negishi, Tomoe, Kimura, Sachiko, Suzuki, Toshinori, Hatano, Tsutomu, Arimoto-Kobayashi, Sakae

“…•UVA-mediated reaction between N-nitrosoproline and DNA.•Identification of five possible guanine modifications.•Three of already known and two not described…”
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Somatic cell mutations caused by 365 nm LED-UVA due to DNA double-strand breaks through oxidative damage by Fang, Xing, Ide, Naohiro, Higashi, Sho-Ichi, Kamei, Yasuhiro, Toyooka, Tatsushi, Ibuki, Yuko, Kawai, Kazuaki, Kasai, Hiroshi, Okamoto, Keinosuke, Arimoto-Kobayashi, Sakae, Negishi, Tomoe

“…Evidence is accumulating indicating that UVA (320-400 nm ultraviolet light) plays an important role in photo-carcinogenesis. UVA is thought to produce reactive…”
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Preventive Effects of Chlorophyllin Fixed on Chitosan towards DNA Adduct Formation of 3-Amino-1-methyl-5H-pyrido[4,3-b]indole in CDF1 Mice by Sugiyama, Chitose, Nakandakari, Namiko, Hayatsu, Hikoya, Arimoto-Kobayashi, Sakae

“…Chlorophyllin, a water-soluble derivative of chlorophyll, is known to suppress the mutagenic and carcinogenic action of compounds having polycyclic structures,…”
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162 β-pseudouridine reduces radiation-induced chromosome aberrations in humanlymphocytes by Manami MONOBE, Sakae ARIMOTO-KOBAYASHI, Koichi ANDO

“…We previously found that drinking beer reduces chromosome aberrations in blood lymphocytes that were collect and irradiated in vitro. In this study, human…”
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Photomutagenicity of N-nitrosoproline dissolved in non-aqueous solvent, oleic acid by Moriwaki, Naofumi, Arimoto-Kobayashi, Sakae

“…In the present study, we investigated the genotoxicity of the active products formed from N-nitrosoproline (NPRO) dissolved in oleic acid following ultraviolet…”
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Genotoxicity and the stability of N-nitrosomorpholine activity following UVA irradiation by Mochizuki, Haruna, Nagazawa, Yukari, Arimoto-Kobayashi, Sakae

“…This study investigated N-nitrosomorpholine (NMOR) genotoxicity following UVA irradiation without metabolic activation. Following UVA irradiation, the photo…”
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