Search Results - "Sakadzic, Sava"

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain by Kisler, Kassandra, Nelson, Amy R, Rege, Sanket V, Ramanathan, Anita, Wang, Yaoming, Ahuja, Ashim, Lazic, Divna, Tsai, Philbert S, Zhao, Zhen, Zhou, Yi, Boas, David A, Sakadžić, Sava, Zlokovic, Berislav V

“…The role of pericytes in the regulation of cerebral blood flow (CBF) and neurovascular coupling remains unclear. Using loss-of-function pericyte-deficient…”
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Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation by Li, Baoqiang, Lu, Xuecong, Moeini, Mohammad, Sakadžić, Sava, Thorin, Eric, Lesage, Frederic

“…Chronic atherosclerosis may cause cerebral hypoperfusion and inadequate brain oxygenation, contributing to the progression of cognitive decline. In this study,…”
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Polarization sensitive optical coherence microscopy for brain imaging by Wang, Hui, Akkin, Taner, Magnain, Caroline, Wang, Ruopeng, Dubb, Jay, Kostis, William J, Yaseen, Mohammad A, Cramer, Avilash, Sakadžić, Sava, Boas, David

“…Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the…”
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Optogenetic Functional Activation Is Detrimental During Acute Ischemic Stroke in Mice by Sugimoto, Kazutaka, Chung, David Y, Fischer, Paul, Takizawa, Tsubasa, Qin, Tao, Yaseen, Mohammad A, Sakadžić, Sava, Ayata, Cenk

“…Functional activation of the focal ischemic brain has been reported to improve outcomes by augmenting collateral blood flow. However, functional activation…”
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Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography by Wang, Hui, Magnain, Caroline, Sakadžić, Sava, Fischl, Bruce, Boas, David A

“…Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and…”
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Fluorescence lifetime microscopy of NADH distinguishes alterations in cerebral metabolism in vivo by Yaseen, Mohammad A, Sutin, Jason, Wu, Weicheng, Fu, Buyin, Uhlirova, Hana, Devor, Anna, Boas, David A, Sakadžić, Sava

“…Evaluating cerebral energy metabolism at microscopic resolution is important for comprehensively understanding healthy brain function and its pathological…”
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Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex by Celaya-Alcala, Jose T, Lee, Grace V, Smith, Amy F, Li, Bohan, Sakadžić, Sava, Boas, David A, Secomb, Timothy W

“…Advanced imaging techniques have made available extensive three-dimensional microvascular network structures. Simulation of oxygen transport by such networks…”
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Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation by Şencan, İkbal, Esipova, Tatiana, Kılıç, Kıvılcım, Li, Baoqiang, Desjardins, Michèle, Yaseen, Mohammad A, Wang, Hui, Porter, Jason E, Kura, Sreekanth, Fu, Buyin, Secomb, Timothy W, Boas, David A, Vinogradov, Sergei A, Devor, Anna, Sakadžić, Sava

“…The cerebral cortex has a number of conserved morphological and functional characteristics across brain regions and species. Among them, the laminar…”
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Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources by Esipova, Tatiana V., Ye, Xingchen, Collins, Joshua E., Sakadžić, Sava, Mandeville, Emiri T., Murray, Christopher B., Vinogradov, Sergei A.

“…We report a group of optical imaging probes, comprising upconverting lanthanide nanoparticles (UCNPs) and polyanionic dendrimers. Dendrimers with rigid cores…”
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At Long Last, PAT Hats for the Lab Rats by Sakadzic, Sava

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The mass transfer coefficient for oxygen transport from blood to tissue in cerebral cortex by Secomb, Timothy W, Bullock, Katherine V, Boas, David A, Sakadžić, Sava

“…The functioning of cerebral cortex depends on adequate tissue oxygenation. MRI-based techniques allow estimation of blood oxygen levels, tissue perfusion, and…”
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“Overshoot” of O 2 Is Required to Maintain Baseline Tissue Oxygenation at Locations Distal to Blood Vessels by Devor, Anna, Sakadžić, Sava, Saisan, Payam A., Yaseen, Mohammad A., Roussakis, Emmanuel, Srinivasan, Vivek J., Vinogradov, Sergei A., Rosen, Bruce R., Buxton, Richard B., Dale, Anders M., Boas, David A.

“…In vivo imaging of cerebral tissue oxygenation is important in defining healthy physiology and pathological departures associated with cerebral disease. We…”
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Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage by Lai, James H., Qin, Tao, Sakadžić, Sava, Ayata, Cenk, Chung, David Y.

“…Background Cortical spreading depolarizations (CSDs) are associated with worse outcomes in patients with aneurysmal subarachnoid hemorrhage (SAH). Animal…”
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Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation by Gagnon, Louis, Smith, Amy F, Boas, David A, Devor, Anna, Secomb, Timothy W, Sakadžić, Sava

“…Oxygen is delivered to brain tissue by a dense network of microvessels, which actively control cerebral blood flow (CBF) through vasodilation and contraction…”
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Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome by Sugimoto, Kazutaka, Yang, Joanna, Fischer, Paul, Takizawa, Tsubasa, Mulder, Inge A., Qin, Tao, Erdogan, Taylan D., Yaseen, Mohammad A., Sakadžić, Sava, Chung, David Y., Ayata, Cenk

“…Spreading depolarizations (SDs) are believed to contribute to injury progression and worsen outcomes in focal cerebral ischemia because exogenously induced SDs…”
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Quantification of Capillary Perfusion in an Animal Model of Acute Intracranial Hypertension by Bordoni, Luca, Li, Baoqiang, Kura, Sreekanth, Boas, David A, Sakadžić, Sava, Østergaard, Leif, Frische, Sebastian, Gutiérrez-Jiménez, Eugenio

“…Intracranial hypertension (IH) is a common feature of many pathologies, including brain edema. In the brain, the extended network of capillaries ensures blood…”
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Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice by Chung, David Y, Oka, Fumiaki, Jin, Gina, Harriott, Andrea, Kura, Sreekanth, Aykan, Sanem A, Qin, Tao, Edmiston, William J, Lee, Hang, Yaseen, Mohammad A, Sakadžić, Sava, Boas, David A, Whalen, Michael J, Ayata, Cenk

“…Aneurysmal subarachnoid hemorrhage (SAH) leads to significant long-term cognitive deficits, which can be associated with alterations in resting state…”
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"Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels by Devor, Anna, Sakadzic, Sava, Saisan, Payam A, Yaseen, Mohammad A, Roussakis, Emmanuel, Srinivasan, Vivek J, Vinogradov, Sergei A, Rosen, Bruce R, Buxton, Richard B, Dale, Anders M, Boas, David A

“…In vivo imaging of cerebral tissue oxygenation is important in defining healthy physiology and pathological departures associated with cerebral disease. We…”
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In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH by Yaseen, Mohammad A, Sakadžić, Sava, Wu, Weicheng, Becker, Wolfgang, Kasischke, Karl A, Boas, David A

“…Minimally invasive, specific measurement of cellular energy metabolism is crucial for understanding cerebral pathophysiology. Here, we present high-resolution,…”
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High-resolution ultrasound-modulated optical tomography in biological tissues by Sakadzić, Sava, Wang, Lihong V

“…We present a novel implementation of high-resolution ultrasound-modulated optical tomography that, based on optical contrast, can image several millimeters…”
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