Emergency subtotal colectomy rates in relation to anti-TNF therapy in inflammatory bowel disease patients: comparison of retrospective cohorts

The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn's disease or indeterminate colitis) du...

Full description

Saved in:

Bibliographic Details
Published in:	Scandinavian journal of gastroenterology Vol. 58; no. 1; pp. 15 - 19
Main Authors:	Sajjadi, Saman, Svensson Neufert, Rebecca, Ruhr, Emilia, Tryggmo, Sebastian, Marsal, Jan, Buchwald, Pamela
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 2023
Subjects:	anti-TNF biological therapy Clinical Medicine colectomy Colectomy - adverse effects Colitis Colitis, Ulcerative - complications Colitis, Ulcerative - drug therapy Colitis, Ulcerative - surgery Gastroenterologi Gastroenterology and Hepatology Humans Inflammatory bowel disease Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - surgery Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Postoperative Complications - epidemiology Prospective Studies Retrospective Studies surgery Tumor Necrosis Factor Inhibitors Inflammatory bowel disease colectomy biological therapy anti-TNF surgery
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn's disease or indeterminate colitis) during two time periods. IBD patients treated with emergency subtotal colectomy for acute severe colitis at Skåne University Hospital, Sweden, during two six-year windows were included. The two time-windows represented pre- and introductory (2004-2009) versus post-introductory (2012-2017) anti-TNF therapy usage. The two periods were compared in terms of the proportion of patients who received anti-TNF therapy, rates of emergency subtotal colectomy, and local IBD prevalence numbers. In total 91 patients were included, 42 (2004-2009) and 49 (2012-2017) patients, respectively. The proportion of patients that received anti-TNF therapy prior to admission was increased from 29% (2004-2009) to 63% (2012-2017) (p = .001). Despite this no significant difference was found in the emergency subtotal colectomy rates between the time periods considering the population at risk (IBD patients living in Skåne county); 1.44/1000 person years versus 1.37/1000 person years (p = .83). Despite an increased proportion of patients with IBD that received anti-TNF therapy prior to admission, no significant decrease in emergency subtotal colectomy rates was noted. Further research is warranted, and a prospective study design would facilitate a better causal understanding.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0036-5521 1502-7708
DOI:	10.1080/00365521.2022.2106151