Search Results - "Sajja, Ravi K."

Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress by Sajja, Ravi K, Rahman, Shafiqur, Cucullo, Luca

“…Psychostimulants and nicotine are the most widely abused drugs with a detrimental impact on public health globally. While the long-term neurobehavioral…”
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HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease by Festoff, Barry W, Sajja, Ravi K, van Dreden, Patrick, Cucullo, Luca

“…The blood-brain barrier (BBB) dysfunction represents an early feature of Alzheimer's disease (AD) that precedes the hallmarks of amyloid beta (amyloid β)…”
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Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity by Prasad, Shikha, Sajja, Ravi K, Kaisar, Mohammad Abul, Park, Jee Hyun, Villalba, Heidi, Liles, Taylor, Abbruscato, Thomas, Cucullo, Luca

“…Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species…”
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Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro by Sajja, Ravi K, Green, Kayla N, Cucullo, Luca

“…Hypoglycemia impairs blood-brain barrier (BBB) endothelial function; a major hallmark in the pathogenesis of various CNS disorders. Previously, we have…”
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New experimental models of the blood-brain barrier for CNS drug discovery by Kaisar, Mohammad A, Sajja, Ravi K, Prasad, Shikha, Abhyankar, Vinay V, Liles, Taylor, Cucullo, Luca

“…The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous…”
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Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure? by Kaisar, Mohammad A., Villalba, Heidi, Prasad, Shikha, Liles, Taylor, Sifat, Ali Ehsan, Sajja, Ravi K., Abbruscato, Thomas J., Cucullo, Luca

“…Recently published in vitro and in vivo findings strongly suggest that BBB impairment and increased risk for stroke by tobacco smoke (TS) closely resemble that…”
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In vitro characterization of odorranalectin for peptide-based drug delivery across the blood-brain barrier by Sajja, Ravi K, Cudic, Predrag, Cucullo, Luca

“…The use of siRNA-based gene silencing has been recently underscored as a potential therapeutic strategy for the treatment of neurological disorders. However,…”
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A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse by Kaisar, Mohammad A, Kallem, Raja Reddy, Sajja, Ravi K, Sifat, Ali Ehsan, Cucullo, Luca

“…A sensitive, rapid and selective UHPLC-MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using…”
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Altered glycaemia differentially modulates efflux transporter expression and activity in hCMEC/D3 cell line by Sajja, Ravi K., Cucullo, Luca

“…•Hypoglycaemia upregulates Pgp and BCRP in BBB endothelial cell line.•Acute hyperglycemia increased only MRP4 expression.•Chronic hyperglycemic fluctuation…”
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Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line by Sajja, Ravi K, Prasad, Shikha, Cucullo, Luca

“…Cerebrovascular complications involving endothelial dysfunction at the blood-brain barrier (BBB) are central to the pathogenesis of diabetes-related CNS…”
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Impact of cigarette smoke extract and hyperglycemic conditions on blood-brain barrier endothelial cells by Prasad, Shikha, Sajja, Ravi K, Park, Jee Hyun, Naik, Pooja, Kaisar, Mohammad Abul, Cucullo, Luca

“…Diabetes and tobacco smoking are significant public health concerns which have been shown to independently impact the blood-brain barrier (BBB). Since smoking…”
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Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10? by Sajja, Ravi K., Prasad, Shikha, Tang, Suni, Kaisar, Mohammad A., Cucullo, Luca

“…•In vivo fluorescence imaging revealed BBB hyper-permeability in diabetic mice.•Nrf2 is significantly down-regulated in diabetic brain.•Nrf2 regulates…”
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Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice by Sajja, Ravi K., Rahman, Shafiqur

“…Brain nicotinic acetylcholine receptors (nAChRs) have been implicated in the rewarding effects of ethanol and other drugs of abuse. The present study examined…”
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Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe? by Naik, Pooja, Fofaria, Neel, Prasad, Shikha, Sajja, Ravi K, Weksler, Babette, Couraud, Pierre-Olivier, Romero, Ignacio A, Cucullo, Luca

“…Both active and passive tobacco smoke (TS) potentially impair the vascular endothelial function in a causative and dose-dependent manner, largely related to…”
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Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice by Sajja, Ravi K., Rahman, Shafiqur

“…Alcohol and nicotine are commonly abused drugs in humans and evidence suggests that neuronal nicotinic acetylcholine receptors (nAChRs) in the midbrain…”
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Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line by Naik, Pooja, Sajja, Ravi K, Prasad, Shikha, Cucullo, Luca

“…Tobacco smoke (TS) toxicity to the brain microvasculature is still an understudied area till date. NF-E2 related factor (Nrf2) is a key transcription factor…”
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In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity by Sajja, Ravi K., Kaisar, Mohammad A., Vijay, Vikrant, Desai, Varsha G., Prasad, Shikha, Cucullo, Luca

“…Sulforaphane (SFN) has been shown to protect the brain vascular system and effectively reduce ischemic injuries and cognitive deficits. Given the robust…”
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Nicotinic receptor partial agonists modulate alcohol deprivation effect in C57BL/6J mice by Sajja, Ravi K., Rahman, Shafiqur

“…Relapse is a core feature of alcohol addiction and hinders the pharmacotherapy of alcohol use disorders. Pre-clinical and clinical studies have shown that…”
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Hyperglycemia exacerbates antiretroviral drug combination induced blood-brain barrier endothelial toxicity by Prasad, Shikha, Sajja, Ravi K., Kaisar, Mohammad A., Cucullo, Luca

“…In this study, we sought to investigate how concomitant hyperglycemia influences the impact of combination antiretroviral therapy on blood-brain barrier (BBB)…”
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In Vitro Cerebrovascular Modeling in the 21st Century: Current and Prospective Technologies by Palmiotti, Christopher A., Prasad, Shikha, Naik, Pooja, Abul, Kaisar M. D., Sajja, Ravi K., Achyuta, Anilkumar H., Cucullo, Luca

“…The blood-brain barrier (BBB) maintains the brain homeostasis and dynamically responds to events associated with systemic and/or rheological impairments (e.g.,…”
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