Search Results - "Saji, Hideo"

In Vivo Molecular Imaging by Saji, Hideo

“…In vivo molecular imaging is the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and…”
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Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice by Morishita, Masaki, Takahashi, Yuki, Nishikawa, Makiya, Sano, Kohei, Kato, Kana, Yamashita, Takuma, Imai, Takafumi, Saji, Hideo, Takakura, Yoshinobu

“…We previously succeeded in the visualization of tissue distribution of B16BL6 cells-derived exosomes by labeling with Gaussia luciferase (gLuc)-LA, a fusion…”
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Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells by Matsumoto, Akihiro, Takahashi, Yuki, Nishikawa, Makiya, Sano, Kohei, Morishita, Masaki, Charoenviriyakul, Chonlada, Saji, Hideo, Takakura, Yoshinobu

“…Exosomes are extracellular vesicles released by various cell types and play roles in cell–cell communication. Several studies indicate that cancer cell‐derived…”
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Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo by Nakase, Ikuhiko, Konishi, Yusuke, Ueda, Masashi, Saji, Hideo, Futaki, Shiroh

“…We investigated the biodistribution of arginine-rich cell-penetrating peptides (CPPs) in tumor-xenografted nude mice after intravenous injection of…”
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Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry by Takai, Nozomi, Tanaka, Yukari, Inazawa, Kazuhiro, Saji, Hideo

“…RATIONALE Recently, the requirement for a quantitative research method using imaging mass spectrometry (IMS) to be developed has been discussed. Specifically,…”
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High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2′-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells by Hagimori, Masayori, Hara, Fumiko, Mizuyama, Naoko, Fujino, Takeshi, Saji, Hideo, Mukai, Takahiro

“…Zinc is an essential trace element involved in many biological activities; however, its functions are not fully understood. To elucidate the role of endogenous…”
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Distinctive detection of insulinoma using [18F]FB(ePEG12)12-exendin-4 PET/CT by Murakami, Takaaki, Fujimoto, Hiroyuki, Hamamatsu, Keita, Yamauchi, Yuki, Kodama, Yuzo, Fujita, Naotaka, Fujikura, Junji, Shimizu, Yoichi, Nakamoto, Yuji, Kimura, Hiroyuki, Saji, Hideo, Inagaki, Nobuya

“…Specifying the exact localization of insulinoma remains challenging due to the lack of insulinoma-specific imaging methods. Recently, glucagon-like peptide-1…”
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Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Novel PET/SPECT Imaging Probes for Diagnosis of Alzheimer’s Disease by Ono, Masahiro, Saji, Hideo

“…Alzheimer’s disease (AD) is a neurodegenerative disease of the brain associated with irreversible cognitive decline, memory impairment, and behavioral changes…”
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A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism by Abe, Tsutomu, Naruse, Mitsuhide, Young, William F, Kobashi, Nobuya, Doi, Yoshihiro, Izawa, Akihiro, Akama, Kei, Okumura, Yuki, Ikenaga, Miho, Kimura, Hiroyuki, Saji, Hideo, Mukai, Kuniaki, Matsumoto, Hiroki

“…Context: Although adrenal vein sampling is the standard method to distinguish unilateral from bilateral forms of primary aldosteronism, it is an invasive and…”
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Synthesis of a Novel Pyrazine⁻Pyridone Biheteroaryl-Based Fluorescence Sensor and Detection of Endogenous Labile Zinc Ions in Lung Cancer Cells by Hagimori, Masayori, Taniura, Mana, Mizuyama, Naoko, Karimine, Yasushi, Kawakami, Shigeru, Saji, Hideo, Mukai, Takahiro

“…A small extent of endogenous labile zinc is involved in many vital physiological roles in living systems. However, its detailed functions have not been fully…”
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Development of Gold Nanorods Conjugated with Radiolabeled Anti-human Epidermal Growth Factor Receptor 2 (HER2) Monoclonal Antibody as Single-Photon Emission Computed Tomography/Photoacoustic Dual-Imaging Probes Targeting HER2-Positive Tumors by Ding, Ning, Sano, Kohei, Shimizu, Yoichi, Watanabe, Hiroyuki, Namita, Takeshi, Shiina, Tsuyoshi, Ono, Masahiro, Saji, Hideo

“…Surgery remains one of the main treatments of cancer and both precise pre- and intraoperative diagnoses are crucial in order to guide the operation. We…”
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Synthesis and Biologic Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for PET of Prostate Cancer by Harada, Naoya, Kimura, Hiroyuki, Onoe, Satoru, Watanabe, Hiroyuki, Matsuoka, Daiko, Arimitsu, Kenji, Ono, Masahiro, Saji, Hideo

“…Prostate-specific membrane antigen (PSMA) is a membrane protein highly expressed on prostate cancer cells and a potential imaging target for diagnosis…”
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Correction to: Selective Cadmium Fluorescence Probe Based on Bis-Heterocyclic Molecule and its Imaging in Cells by Hagimori, Masayori, Karimine, Yasushi, Mizuyama, Naoko, Hara, Fumiko, Fujino, Takeshi, Saji, Hideo, Mukai, Takahiro

“…The original version of this article unfortunately contained a mistake. The equation under “Experimental -- Spectroscopic Studies” section should be corrected…”
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Selective Cadmium Fluorescence Probe Based on Bis-heterocyclic Molecule and its Imaging in Cells by Hagimori, Masayori, Karimine, Yasushi, Mizuyama, Naoko, Hara, Fumiko, Fujino, Takeshi, Saji, Hideo, Mukai, Takahiro

“…Fluorescence probes that selectively image cadmium are useful for detecting and tracking the amount of Cd 2+ in cells and tissues. In this study, we designed…”
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Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyl-technetium-labeled A-85380: An imaging probe for single-photon emission computed tomography investigation of nicotinic acetylcholine receptors in the brain by Kimura, Hiroyuki, Ueda, Masashi, Kawashima, Hidekazu, Arimitsu, Kenji, Yagi, Yusuke, Saji, Hideo

“…[Display omitted] We have designed (S)-(5-(azetidin-2-ylmethoxy)pyridine-3-yl)methyl cyclopentadienyltricarbonyl technetium carboxylate ([99mTc]CPTT–A–E) with…”
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Development of Technetium-99m-Labeled BODIPY-Based Probes Targeting Lipid Droplets Toward the Diagnosis of Hyperlipidemia-Related Diseases by Shimizu, Yoichi, Tanimura, Keiichi, Iikuni, Shimpei, Watanabe, Hiroyuki, Saji, Hideo, Ono, Masahiro

“…Hyperlipidemia causes systemic lipid disorder, which leads to hepatic steatosis and atherosclerosis. Thus, it is necessary to detect these syndromes early and…”
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Synthesis and biological evaluation of F-18 labeled tetrahydroisoquinoline derivatives targeting orexin 1 receptor by Watanabe, Hiroyuki, Fukui, Kengo, Shimizu, Yoichi, Idoko, Yuki, Nakamoto, Yuji, Togashi, Kaori, Saji, Hideo, Ono, Masahiro

“…[Display omitted] Orexin 1 receptor (OX1R) is thought to be involved in various body functions, including arousal maintenance and emotional control, but the…”
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Molecular Imaging of β-Amyloid Plaques with Near-Infrared Boron Dipyrromethane (BODIPY)-Based Fluorescent Probes by Watanabe, Hiroyuki, Ono, Masahiro, Matsumura, Kenji, Yoshimura, Masashi, Kimura, Hiroyuki, Saji, Hideo

“…The formation of β-amyloid (Aβ) plaques is a critical neurodegenerative change in Alzheimer disease (AD). We designed and synthesized novel boron…”
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In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor by Sano, Kohei, Ohashi, Manami, Kanazaki, Kengo, Ding, Ning, Deguchi, Jun, Kanada, Yuko, Ono, Masahiro, Saji, Hideo

“…Photoacoustic (PA) imaging is an attractive imaging modality for sensitive and depth imaging of biomolecules with high resolution in vivo. The aim of this…”
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Fluorescence ON/OFF switching Zn2+ sensor based on pyridine–pyridone scaffold by Hagimori, Masayori, Uto, Takuhiro, Mizuyama, Naoko, Temma, Takashi, Yamaguchi, Yasuchika, Tominaga, Yoshinori, Saji, Hideo

“…We report a novel series of fluorescent Zn2+ sensors based on a pyridine–pyridone core structure, which functions as both the chelating part for Zn2+ and as…”
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