Impregnation of catheters with anacardic acid from cashew nut shell prevents Staphylococcus aureus biofilm development

Impregnation of catheters with anacardic acid from cashew nut shell prevents Staphylococcus aureus biofilm development

Aim The effect of anacardic acid impregnation on catheter surfaces for the prevention of Staphylococcus aureus attachments and biofilm formations were evaluated. Methods and Results Silicon catheter tubes were impregnated using different concentrations of anacardic acids (0·002–0·25%). Anacardic aci...

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Bibliographic Details
Published in:Journal of applied microbiology Vol. 125; no. 5; pp. 1286 - 1295
Main Authors: Sajeevan, S.E., Chatterjee, M., Paul, V., Baranwal, G., Kumar, V.A., Bose, C., Banerji, A., Nair, B.G., Prasanth, B.P., Biswas, R.
Format: Journal Article
Language:English
Published: England Oxford University Press 01-11-2018
Subjects:
Acids
anacardic acid
Anacardic Acids - pharmacology
Anacardium - chemistry
Anacardium occidentale
Anti-Bacterial Agents - pharmacology
Antiinfectives and antibacterials
antimicrobial agent
Antimicrobial agents
biofilm
Biofilms
Biofilms - drug effects
Biomedical materials
catheter
Catheters
Colonization
Controlled release
Impregnation
Infections
Lipids
Medical instruments
Phenols
Silicon
staphylococcus
Staphylococcus aureus
Staphylococcus aureus - drug effects
Sustained release
catheter
antimicrobial agent
anacardic acid
biofilm
staphylococcus
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Summary:Aim The effect of anacardic acid impregnation on catheter surfaces for the prevention of Staphylococcus aureus attachments and biofilm formations were evaluated. Methods and Results Silicon catheter tubes were impregnated using different concentrations of anacardic acids (0·002–0·25%). Anacardic acids are antibacterial phenolic lipids from cashew nut (Anacardium occidentale) shell oil. Anacardic acid‐impregnated silicon catheters revealed no significant haemolytic activity and were cytocompatible against fibroblast cell line (L929). Sustained release of anacardic acids was observed for 4 days. Anacardic acid‐impregnated silicon catheters efficiently inhibited S. aureus colonization and the biofilm formation on its surface. The in vivo antibiofilm activity of anacardic acid‐impregnated catheters was tested in an intraperitoneal catheter‐associated medaka fish infection model. Significant reduction in S. aureus colonization on anacardic acid‐impregnated catheter tubes was observed. Conclusions Our data suggest that anacardic acid‐impregnated silicon catheters may help in preventing catheter‐related staphylococcal infections. Significance and Impact of the Study This study opens new directions for designing antimicrobial phytochemical‐coated surfaces with ideal antibiofilm properties and could be of great interest for biomedical research scientists.
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ISSN:1364-5072
1365-2672
DOI:10.1111/jam.14040