Search Results - "Saiz‐Sanchez, Daniel"
-
1
Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells
Published in Brain pathology (Zurich, Switzerland) (01-07-2024)“…Alzheimer's disease (AD), the most prevalent neurodegenerative disorder worldwide, is clinically characterized by cognitive deficits. Neuropathologically, AD…”
Get full text
Journal Article -
2
Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease
Published in International journal of molecular sciences (23-12-2021)“…Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, is characterized by executive dysfunction and memory impairment mediated by the…”
Get full text
Journal Article -
3
Anxiety among Medical Students when Faced with the Practice of Anatomical Dissection
Published in Anatomical sciences education (01-05-2019)“…Practical training in the dissection of human cadavers is a fundamental and traditional component of human anatomy education in medical schools. This practice,…”
Get full text
Journal Article -
4
Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy
Published in Journal of Parkinson's disease (01-01-2019)“…Parkinson's disease (PD) is a synucleinopathy that has multiple neuropathological characteristics, with nigrostriatal dopamine system degeneration being a core…”
Get more information
Journal Article -
5
The Importance of Optional Practical Anatomy Courses for Undergraduate Speech Therapy Students
Published in Anatomical sciences education (01-01-2022)“…An in‐depth understanding of the anatomy discipline is essential for the work of healthcare professionals. In recent decades, the content and time of teaching…”
Get full text
Journal Article -
6
Neurodegeneration and astrogliosis in the entorhinal cortex in Alzheimer's disease: Stereological layer‐specific assessment and proteomic analysis
Published in Alzheimer's & dementia (01-12-2022)“…Introduction The entorhinal cortex is among the earliest areas involved in Alzheimer's disease. Volume reduction and neural loss in this area have been widely…”
Get full text
Journal Article -
7
Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis
Published in Brain pathology (Zurich, Switzerland) (01-09-2023)“…Alzheimer's disease (AD) is characterized by the accumulation of pathological amyloid‐β (Aβ) and Tau proteins. According to the prion‐like hypothesis, both…”
Get full text
Journal Article -
8
The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases
Published in Translational neurodegeneration (03-06-2020)“…Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders. Their etiologies are idiopathic, and treatments are symptomatic and…”
Get full text
Journal Article -
9
Somatostatin and Astroglial Involvement in the Human Limbic System in Alzheimer’s Disease
Published in International journal of molecular sciences (05-08-2021)“…Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the elderly. Progressive accumulation of insoluble isoforms of amyloid-β peptide…”
Get full text
Journal Article -
10
Interneurons in the human olfactory system in Alzheimer's disease
Published in Experimental neurology (01-02-2016)“…The principal olfactory structures display Alzheimer's disease (AD) related pathology at early stages of the disease. Consequently, olfactory deficits are…”
Get full text
Journal Article -
11
Somatostatin, Olfaction, and Neurodegeneration
Published in Frontiers in neuroscience (19-02-2020)“…Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative disorders in aging. Hyposmia has been described as an early symptom that can…”
Get full text
Journal Article -
12
Hippocampal α-synuclein and interneurons in Parkinson's disease: Data from human and mouse models
Published in Movement disorders (01-07-2016)“…ABSTRACT Background Dementia is a nonmotor feature of Parkinson's disease, arising around the onset of hippocampal pathology in stage IV of the disease, from…”
Get full text
Journal Article -
13
Differential Effects of Parkinson's Disease on Interneuron Subtypes within the Human Anterior Olfactory Nucleus
Published in Frontiers in neuroanatomy (05-12-2017)“…Synucleinopathies (including α-synucleinopathies), which include Parkinson's disease (PD), manifest themsevles early on (stage 1) in the olfactory system;…”
Get full text
Journal Article -
14
Neuronal and glial characterization in the rostrocaudal axis of the human anterior olfactory nucleus: Involvement in Parkinson’s disease
Published in Frontiers in neuroanatomy (18-07-2022)“…Hyposmia is one of the prodromal symptoms of Parkinson’s disease (PD) and a red flag in clinical diagnosis. Neuropathologically, this sign correlates with…”
Get full text
Journal Article -
15
HUNTINGTIN DISTRIBUTION, GLIAL INVOLVEMENT AND COPATHOLOGIES IN THE HUMAN AMYGDALA IN HUNTINGTON’S DISEASE
Published in IBRO neuroscience reports (01-10-2023)Get full text
Journal Article -
16
Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson’s disease
Published in NPJ Parkinson's Disease (21-01-2021)“…Hyposmia is prodromal, and male sex is a risk marker for an enhanced likelihood ratio of Parkinson’s disease. The literature regarding olfactory bulb volume…”
Get full text
Journal Article -
17
Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson's disease A53T mouse model
Published in Acta neuropathologica communications (15-04-2019)“…Parkinson's disease is characterized by a proteinopathy that includes aggregates of α-synuclein. A recent hypothesis proposes a prion-like spreading mechanism…”
Get full text
Journal Article -
18
Neurogenesis, Neurodegeneration, Interneuron Vulnerability, and Amyloid-β in the Olfactory Bulb of APP/PS1 Mouse Model of Alzheimer's Disease
Published in Frontiers in neuroscience (30-05-2016)“…Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, mostly idiopathic and with palliative treatment. Neuropathologically, it is…”
Get full text
Journal Article -
19
α-Synuclein staging in the amygdala of a Parkinson's disease model: cell types involved
Published in The European journal of neuroscience (01-01-2015)“…Lewy bodies (ubiquitin and α‐synuclein aggregates) can be detected in brain areas in a predictable sequence of six neuropathological stages in Parkinson's…”
Get full text
Journal Article -
20
ROLE OF ANXA2, HSP90AA1 AND PTK2B IN SYNAPTIC HOMEOSTASIS THROUGH MICROGLIAL CELLS IN THE HUMAN ENTORHINAL CORTEX IN ALZHEIMER’S DISEASE
Published in IBRO neuroscience reports (01-10-2023)Get full text
Journal Article