Search Results - "Saitou, Takashi"

Wide field light-sheet microscopy with lens-axicon controlled two-photon Bessel beam illumination by Takanezawa, Sota, Saitou, Takashi, Imamura, Takeshi

“…Two-photon excitation can lower phototoxicity and improve penetration depth, but its narrow excitation range restricts its applications in light-sheet…”
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In vivo optical imaging of cancer cell function and tumor microenvironment by Imamura, Takeshi, Saitou, Takashi, Kawakami, Ryosuke

“…In vivo optical imaging using fluorescence and bioluminescence is superior to other methods in terms of spatiotemporal resolution and specificity, and…”
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Extended Depth of Focus Two-Photon Light-Sheet Microscopy for In Vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution by Saitou, Takashi, Imamura, Takeshi

“…Two-photon excitation in light-sheet microscopy advances applications to live imaging of multicellular organisms. In a previous study, we developed a…”
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Quantitative Morphometry for Osteochondral Tissues Using Second Harmonic Generation Microscopy and Image Texture Information by Saitou, Takashi, Kiyomatsu, Hiroshi, Imamura, Takeshi

“…Osteoarthritis (OA) is a chronic joint disorder involving degeneration of articular cartilage and subchondral bone in joints. We previously established a…”
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Therapeutic effects of the PKR inhibitor C16 suppressing tumor proliferation and angiogenesis in hepatocellular carcinoma in vitro and in vivo by Watanabe, Takao, Ninomiya, Hiroko, Saitou, Takashi, Takanezawa, Sota, Yamamoto, Shin, Imai, Yusuke, Yoshida, Osamu, Kawakami, Ryosuke, Hirooka, Masashi, Abe, Masanori, Imamura, Takeshi, Hiasa, Yoichi

“…The therapeutic effects of C16, which is an inhibitor of RNA-dependent protein kinase (PKR), on growth of hepatocellular carcinoma (HCC) cells and tumor…”
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Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment–colorectal cancer network by Ieda, Takeshi, Tazawa, Hiroshi, Okabayashi, Hiroki, Yano, Shuya, Shigeyasu, Kunitoshi, Kuroda, Shinji, Ohara, Toshiaki, Noma, Kazuhiro, Kishimoto, Hiroyuki, Nishizaki, Masahiko, Kagawa, Shunsuke, Shirakawa, Yasuhiro, Saitou, Takashi, Imamura, Takeshi, Fujiwara, Toshiyoshi

“…Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial cells acquire mesenchymal characteristics. In malignant tumors, EMT is…”
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The HIV co-receptor CCR5 regulates osteoclast function by Lee, Ji-Won, Hoshino, Akiyoshi, Inoue, Kazuki, Saitou, Takashi, Uehara, Shunsuke, Kobayashi, Yasuhiro, Ueha, Satoshi, Matsushima, Kouji, Yamaguchi, Akira, Imai, Yuuki, Iimura, Tadahiro

“…C–C chemokine receptor 5 (CCR5) is a co-receptor of HIV. Epidemiological findings suggest that the functional loss of CCR5 is correlated with a lower incidence…”
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PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis by Okujima, Yusuke, Watanabe, Takao, Ito, Takeshi, Inoue, Yasumichi, Kasai, Yutaka, Imai, Yusuke, Nakamura, Yoshiko, Koizumi, Mitsuhito, Yoshida, Osamu, Tokumoto, Yoshio, Hirooka, Masashi, Abe, Masanori, Kawakami, Ryosuke, Saitou, Takashi, Imamura, Takeshi, Murakami, Yoshinori, Hiasa, Yoichi

“…RNA-dependent protein kinase (PKR) may have a positive regulatory role in controlling tumor growth and progression in hepatocellular carcinoma (HCC). However,…”
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Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis by Nakamura, Yutaka, Saitou, Mitsuru, Komura, Shingo, Matsumoto, Kazu, Ogawa, Hiroyasu, Miyagawa, Takaki, Saitou, Takashi, Imamura, Takeshi, Imai, Yuuki, Takayanagi, Hiroshi, Akiyama, Haruhiko

“…Developmental dysplasia of the hip (DDH) is characterized by anatomical abnormalities of the hip joint, ranging from mild acetabular dysplasia to hip…”
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A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone by Kushioka, Junichi, Kaito, Takashi, Okada, Rintaro, Ishiguro, Hiroyuki, Bal, Zeynep, Kodama, Joe, Chijimatsu, Ryota, Pye, Melanie, Narimatsu, Masahiro, Wrana, Jeffrey L, Inoue, Yasumichi, Ninomiya, Hiroko, Yamamoto, Shin, Saitou, Takashi, Yoshikawa, Hideki, Imamura, Takeshi

“…Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors…”
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Computer-Aided Detection of Quantitative Signatures for Breast Fibroepithelial Tumors Using Label-Free Multi-Photon Imaging by Kobayashi-Taguchi, Kana, Saitou, Takashi, Kamei, Yoshiaki, Murakami, Akari, Nishiyama, Kanako, Aoki, Reina, Kusakabe, Erina, Noda, Haruna, Yamashita, Michiko, Kitazawa, Riko, Imamura, Takeshi, Takada, Yasutsugu

“…Fibroadenomas (FAs) and phyllodes tumors (PTs) are major benign breast tumors, pathologically classified as fibroepithelial tumors. Although the clinical…”
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3D in vivo imaging of the keratin filament network in the mouse stratum granulosum reveals profilaggrin-dependent regulation of keratin bundling by Usui, Keiko, Kadono, Nanako, Furuichi, Yuki, Shiraga, Keiichiro, Saitou, Takashi, Kawasaki, Hiroshi, Toyooka, Kiminori, Tamura, Hiroomi, Kubo, Akiharu, Amagai, Masayuki, Matsui, Takeshi

“…•We visualized keratin filament networks in epidermal stratum granulosum in vivo.•mCherry-keratin 1 labeled keratin filaments without affecting filament…”
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Roles of raft-anchored adaptor Cbp/PAG1 in spatial regulation of c-Src kinase by Saitou, Takashi, Kajiwara, Kentaro, Oneyama, Chitose, Suzuki, Takashi, Okada, Masato

“…The tyrosine kinase c-Src is upregulated in numerous human cancers, implying a role for c-Src in cancer progression. Previously, we have shown that…”
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Comparative analysis of Hmx expression and the distribution of neuronal somata in the trigeminal ganglion in lamprey and shark: insights into the homology of the trigeminal nerve branches and the evolutionary origin of the vertebrate jaw by Tamura, Motoki, Ishikawa, Ryota, Nakanishi, Yuki, Pascual-Anaya, Juan, Fukui, Makiko, Saitou, Takashi, Sugahara, Fumiaki, Rijli, Filippo M, Kuratani, Shigeru, Suzuki, Daichi G, Murakami, Yasunori

“…Abstract The evolutionary origin of the jaw remains one of the most enigmatic events in vertebrate evolution. The trigeminal nerve is a key component for…”
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Quantitative SHG imaging in osteoarthritis model mice, implying a diagnostic application by Kiyomatsu, Hiroshi, Oshima, Yusuke, Saitou, Takashi, Miyazaki, Tsuyoshi, Hikita, Atsuhiko, Miura, Hiromasa, Iimura, Tadahiro, Imamura, Takeshi

“…Osteoarthritis (OA) restricts the daily activities of patients and significantly decreases their quality of life. The development of non-invasive quantitative…”
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Live imaging-based model selection reveals periodic regulation of the stochastic G1/S phase transition in vertebrate axial development by Sugiyama, Mayu, Saitou, Takashi, Kurokawa, Hiroshi, Sakaue-Sawano, Asako, Imamura, Takeshi, Miyawaki, Atsushi, Iimura, Tadahiro

“…In multicellular organism development, a stochastic cellular response is observed, even when a population of cells is exposed to the same environmental…”
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Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions by Khan, Sakirul, Takeuchi, Akihide, Nabeka, Hiroaki, Khan, Farzana, Shimokawa, Tetsuya, Takanezawa, Sota, Saitou, Takashi, Imamura, Takeshi, Tachibana, Tetsuya, Nishizono, Akira, Hamada, Fumihiko, Matsuda, Seiji

“…Neural tube defects (NTDs) cause fetal and pediatric deaths or lifelong neurological disabilities. No effective treatment is currently available for NTDs. We…”
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Mathematical modeling of invadopodia formation by Saitou, Takashi, Rouzimaimaiti, Mahemuti, Koshikawa, Naohiko, Seiki, Motoharu, Ichikawa, Kazuhisa, Suzuki, Takashi

“…In invasive cancer cells, specialized sub-cellular membrane structures which carry out a pivotal process in cancer invasion, termed invadopodia, are observed…”
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Tongue pressure in patients with tongue cancer resection and reconstruction by Hamahata, Atsumori, Beppu, Takesi, Shirakura, Satoshi, Hatanaka, Akio, Yamaki, Takashi, Saitou, Takashi, Sakurai, Hiroyuki

“…Abstract Objective Assessment of tongue function following tongue reconstruction is important to evaluate patient status. To assess tongue function in patients…”
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Tissue Intrinsic Fluorescence Spectra-Based Digital Pathology of Liver Fibrosis by Marker-Controlled Segmentation by Saitou, Takashi, Takanezawa, Sota, Ninomiya, Hiroko, Watanabe, Takao, Yamamoto, Shin, Hiasa, Yoichi, Imamura, Takeshi

“…Tissue intrinsic emission fluorescence provides useful diagnostic information for various diseases. Because of its unique feature of spectral profiles…”
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