Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs

Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs

A common sign of obesity, in dogs, is hyperlipidemia, which is characterized by hypercholesterolemia and/or hypertriglycemia. Hyperlipidemia can be caused by a quantitative increase in circulating lipoproteins (LP) or by a higher lipid concentration in the various LP classes. In this study, we sough...

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Bibliographic Details
Published in:Veterinary research communications Vol. 35; no. 4; pp. 223 - 235
Main Authors: Mori, Nobuko, Lee, Peter, Kondo, Kazuo, Kido, Toshimi, Saito, Terumasa, Arai, Toshiro
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-04-2011
Springer Nature B.V
Subjects:
Age Factors
Animals
Biomedical and Life Sciences
Body Composition
Cholesterol - blood
Dog Diseases - blood
Dog Diseases - diagnosis
Dog Diseases - epidemiology
Dogs
Electrophoresis
Female
Japan
Life Sciences
Linear Models
Lipoproteins - blood
Male
Multivariate Analysis
Obesity - diagnosis
Obesity - epidemiology
Obesity - veterinary
Original Article
Physical Examination - methods
Prospective Studies
Sex Factors
Ultracentrifugation
Veterinary Medicine/Veterinary Science
Zoology
Japan
HDL1
Obesity
Lipoprotein
Dog
Cholesterol
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Summary:A common sign of obesity, in dogs, is hyperlipidemia, which is characterized by hypercholesterolemia and/or hypertriglycemia. Hyperlipidemia can be caused by a quantitative increase in circulating lipoproteins (LP) or by a higher lipid concentration in the various LP classes. In this study, we sought to determine whether aberrations occur with cholesterol lipoprotein profile, especially with sub HDL-cholesterol fraction % in obese dogs. Using clinically healthy and disease free (no overt signs) body condition score classified obese dogs, of all ages, we attempted to determine the influence of age, gender and obesity status on cholesterol lipoprotein profiling. Overall, no aberration in pattern was observed in obese dogs <8 years of age. However, in older obese animals (≥8 years of age), the general aberration pattern to cholesterol lipoprotein observed was that a significant decrease in HDL2 and 3 fraction % occurs with a concomitant increase in either HDL1-Cho or VLDL and LDL -Cho fraction % depending on gender. Linear regression analysis indicated that obesity status appears to significantly affect total cholesterol, HDL2 and 3-Cho, VLDL and LDL-Cho levels ( P  = 0.02, 0.046, and 0.045, respectively), whereas it is borderline with HDL1-Cho ( P  = 0.062). On the other hand, age significantly influenced TG, Total cholesterol, and HDL1-Cho levels ( P  = 0.009, 0.006, and 0.002, respectively), while gender influenced VLDL and LDL-Cho ( P  = 0.024) level. Therefore, aberrations in cholesterol lipoprotein profile pattern might be of potential use to assess and diagnose obesity status, in conjunction with BCS, especially of older overweight animals which might be considered borderline obese.
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ISSN:0165-7380
1573-7446
DOI:10.1007/s11259-011-9466-x