Search Results - "Saito, Nayuta"

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis by Yoshida, Masahiro, Minagawa, Shunsuke, Araya, Jun, Sakamoto, Taro, Hara, Hiromichi, Tsubouchi, Kazuya, Hosaka, Yusuke, Ichikawa, Akihiro, Saito, Nayuta, Kadota, Tsukasa, Sato, Nahoko, Kurita, Yusuke, Kobayashi, Kenji, Ito, Saburo, Utsumi, Hirohumi, Wakui, Hiroshi, Numata, Takanori, Kaneko, Yumi, Mori, Shohei, Asano, Hisatoshi, Yamashita, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nakayama, Katsutoshi, Iwamoto, Takeo, Imai, Hirotaka, Kuwano, Kazuyoshi

“…Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-mediated Fenton reactions…”
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Chaperone‐mediated autophagy receptor modulates tumor growth and chemoresistance in non–small cell lung cancer by Ichikawa, Akihiro, Fujita, Yu, Hosaka, Yusuke, Kadota, Tsukasa, Ito, Akihiko, Yagishita, Shigehiro, Watanabe, Naoaki, Fujimoto, Shota, Kawamoto, Hironori, Saito, Nayuta, Yoshida, Masahiro, Hashimoto, Mitsuo, Minagawa, Shunsuke, Hara, Hiromichi, Motoi, Noriko, Yamamoto, Yusuke, Ochiya, Takahiro, Araya, Jun, Kuwano, Kazuyoshi

“…Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway of selective soluble proteins. Lysosome‐associated membrane protein type 2a (LAMP2A) is…”
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Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis by Tsubouchi, Kazuya, Araya, Jun, Yoshida, Masahiro, Sakamoto, Taro, Koumura, Tomoko, Minagawa, Shunsuke, Hara, Hiromichi, Hosaka, Yusuke, Ichikawa, Akihiro, Saito, Nayuta, Kadota, Tsukasa, Kurita, Yusuke, Kobayashi, Kenji, Ito, Saburo, Fujita, Yu, Utsumi, Hirofumi, Hashimoto, Mitsuo, Wakui, Hiroshi, Numata, Takanori, Kaneko, Yumi, Mori, Shohei, Asano, Hisatoshi, Matsudaira, Hideki, Ohtsuka, Takashi, Nakayama, Katsutoshi, Nakanishi, Yoichi, Imai, Hirotaka, Kuwano, Kazuyoshi

“…The imbalanced redox status in lung has been widely implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis. To regulate redox status, hydrogen peroxide…”
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Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4 by Tsubouchi, Kazuya, Araya, Jun, Minagawa, Shunsuke, Hara, Hiromichi, Ichikawa, Akihiro, Saito, Nayuta, Kadota, Tsukasa, Sato, Nahoko, Yoshida, Masahiro, Kurita, Yusuke, Kobayashi, Kenji, Ito, Saburo, Fujita, Yu, Utsumi, Hirofumi, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Wakui, Hiroshi, Yoshii, Yutaka, Ishikawa, Takeo, Numata, Takanori, Kaneko, Yumi, Asano, Hisatoshi, Yamashita, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nakayama, Katsutoshi, Nakanishi, Yoichi, Kuwano, Kazuyoshi

“…Accumulation of profibrotic myofibroblasts is involved in the process of fibrosis development during idiopathic pulmonary fibrosis (IPF) pathogenesis. TGFB…”
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Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis by Saito, Nayuta, Araya, Jun, Ito, Saburo, Tsubouchi, Kazuya, Minagawa, Shunsuke, Hara, Hiromichi, Ito, Akihiko, Nakano, Takayuki, Hosaka, Yusuke, Ichikawa, Akihiro, Kadota, Tsukasa, Yoshida, Masahiro, Fujita, Yu, Utsumi, Hirofumi, Kurita, Yusuke, Kobayashi, Kenji, Hashimoto, Mitsuo, Wakui, Hiroshi, Numata, Takanori, Kaneko, Yumi, Asano, Hisatoshi, Odaka, Makoto, Ohtsuka, Takashi, Morikawa, Toshiaki, Nakayama, Katsutoshi, Kuwano, Kazuyoshi

“…Downregulation of lamin B1 has been recognized as a crucial step for development of full senescence. Accelerated cellular senescence linked to mechanistic…”
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Chaperone-Mediated Autophagy Suppresses Apoptosis via Regulation of the Unfolded Protein Response during Chronic Obstructive Pulmonary Disease Pathogenesis by Hosaka, Yusuke, Araya, Jun, Fujita, Yu, Kadota, Tsukasa, Tsubouchi, Kazuya, Yoshida, Masahiro, Minagawa, Shunsuke, Hara, Hiromichi, Kawamoto, Hironori, Watanabe, Naoaki, Ito, Akihiko, Ichikawa, Akihiro, Saito, Nayuta, Okuda, Keitaro, Watanabe, Junko, Takekoshi, Daisuke, Utsumi, Hirofumi, Hashimoto, Mitsuo, Wakui, Hiroshi, Ito, Saburo, Numata, Takanori, Mori, Shohei, Matsudaira, Hideki, Hirano, Jun, Ohtsuka, Takashi, Nakayama, Katsutoshi, Kuwano, Kazuyoshi

“…Cigarette smoke (CS) induces accumulation of misfolded proteins with concomitantly enhanced unfolded protein response (UPR). Increased apoptosis linked to UPR…”
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Impact of renal function-based anti-tuberculosis drug dosage adjustment on efficacy and safety outcomes in pulmonary tuberculosis complicated with chronic kidney disease by Saito, Nayuta, Yoshii, Yutaka, Kaneko, Yugo, Nakashima, Akio, Horikiri, Tsugumi, Saito, Zenya, Watanabe, Sho, Kinoshita, Akira, Saito, Keisuke, Kuwano, Kazuyoshi

“…Dosages of anti-tuberculosis (TB) drugs are recommended to be adjusted according to renal function for patients complicated with chronic kidney disease (CKD)…”
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Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis by Araya, Jun, Saito, Nayuta, Hosaka, Yusuke, Ichikawa, Akihiro, Kadota, Tsukasa, Fujita, Yu, Minagawa, Shunsuke, Hara, Hiromichi, Fujimoto, Shota, Kawamoto, Hironori, Watanabe, Naoaki, Ito, Akihiko, Okuda, Keitaro, Miyagawa, Hanae, Watanabe, Junko, Takekoshi, Daisuke, Utsumi, Hirofumi, Yoshida, Masahiro, Hashimoto, Mitsuo, Wakui, Hiroshi, Ito, Saburo, Numata, Takanori, Mori, Shohei, Matsudaira, Hideki, Hirano, Jun, Ohtsuka, Takashi, Nakayama, Katsutoshi, Kuwano, Kazuyoshi

“…Insufficient autophagic degradation has been implicated in accelerated cellular senescence during chronic obstructive pulmonary disease (COPD) pathogenesis…”
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Risk factors of postoperative pulmonary complications in patients with asthma and COPD by Numata, Takanori, Nakayama, Katsutoshi, Fujii, Satoko, Yumino, Yoko, Saito, Nayuta, Yoshida, Masahiro, Kurita, Yusuke, Kobayashi, Kenji, Ito, Saburo, Utsumi, Hirofumi, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Wakui, Hiroshi, Minagawa, Shunsuke, Ishikawa, Takeo, Hara, Hiromichi, Araya, Jun, Kaneko, Yumi, Kuwano, Kazuyoshi

“…Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has…”
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Increased levels of prostaglandin E−major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia by Horikiri, Tsugumi, Hara, Hiromichi, Saito, Nayuta, Araya, Jun, Takasaka, Naoki, Utsumi, Hirofumi, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Yoshii, Yutaka, Wakui, Hiroshi, Minagawa, Shunsuke, Ishikawa, Takeo, Shimizu, Kenichiro, Numata, Takanori, Arihiro, Seiji, Kaneko, Yumi, Nakayama, Katsutoshi, Matsuura, Tomokazu, Matsuura, Masaaki, Fujiwara, Mutsunori, Okayasu, Isao, Ito, Satoru, Kuwano, Kazuyoshi

“…Abstract Background Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the…”
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Asthmatic Attack Complicated with Takotsubo Cardiomyopathy after Frequent Inhalation of Inhaled Corticosteroids/Long-Acting Beta2-Adrenoceptor Agonists by Saito, Nayuta, Suzuki, Manabu, Ishii, Satoru, Morino, Eriko, Takasaki, Jin, Naka, Go, Iikura, Motoyasu, Takeda, Yuichiro, Hojo, Masayuki, Sugiyama, Haruhito

“…A 63-year-old man was transferred to our hospital because of an exacerbation of asthma. His symptoms deteriorated even after increasing the dose of inhaled…”
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Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy by Kurita, Yusuke, Araya, Jun, Minagawa, Shunsuke, Hara, Hiromichi, Ichikawa, Akihiro, Saito, Nayuta, Kadota, Tsukasa, Tsubouchi, Kazuya, Sato, Nahoko, Yoshida, Masahiro, Kobayashi, Kenji, Ito, Saburo, Fujita, Yu, Utsumi, Hirofumi, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Wakui, Hiroshi, Yoshii, Yutaka, Ishikawa, Takeo, Numata, Takanori, Kaneko, Yumi, Asano, Hisatoshi, Yamashita, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nakayama, Katsutoshi, Kuwano, Kazuyoshi

“…Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive…”
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Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods by Shimizu, Kenichiro, Yoshii, Yutaka, Morozumi, Miyuki, Chiba, Naoko, Ubukata, Kimiko, Uruga, Hironori, Hanada, Shigeo, Saito, Nayuta, Kadota, Tsukasa, Ito, Saburo, Wakui, Hiroshi, Takasaka, Naoki, Minagawa, Shunsuke, Kojima, Jun, Hara, Hiromichi, Numata, Takanori, Kawaishi, Makoto, Saito, Keisuke, Araya, Jun, Kaneko, Yumi, Nakayama, Katsutoshi, Kishi, Kazuma, Kuwano, Kazuyoshi

“…Respiratory infection is a major cause of exacerbation in chronic obstructive pulmonary disease (COPD). Infectious contributions to exacerbations remain…”
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Paradoxical response with increased tumor necrosis factor-α levels to anti-tuberculosis treatment in a patient with disseminated tuberculosis by Watanabe, Sho, Kaneko, Yugo, Kawamoto, Hironori, Maehara, Tomoki, Baba, Yuri, Fujisaki, Ikumi, Saito, Nayuta, Ryu, Kai, Seki, Aya, Horikiri, Tsugumi, Kinoshita, Akira, Takeda, Hiroshi, Saito, Keisuke, Kuwano, Kazuyosi

“…Abstract It has been reported that tuberculosis (TB) worsens after cessation of tumor necrosis factor-α inhibitors and starting anti-TB treatment. Little is…”
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A case of Legionella pneumophila pneumonia accompanied by acute respiratory distress syndrome and epilepsy by Saito, Nayuta, Shimizu, Kenichiro, Yoshii, Yutaka, Kojima, Jun, Ishikawa, Takeo, Saito, Keisuke, Kuwano, Kazuyoshi

“…A 32-year-old female with epilepsy presented at our hospital with high-grade fever, seizures, and unconsciousness. She was initially treated for aspiration…”
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PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis by Araya, Jun, Tsubouchi, Kazuya, Sato, Nahoko, Ito, Saburo, Minagawa, Shunsuke, Hara, Hiromichi, Hosaka, Yusuke, Ichikawa, Akihiro, Saito, Nayuta, Kadota, Tsukasa, Yoshida, Masahiro, Fujita, Yu, Utsumi, Hirofumi, Kobayashi, Kenji, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Wakui, Hiroshi, Ishikawa, Takeo, Numata, Takanori, Kaneko, Yumi, Asano, Hisatoshi, Yamashita, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nishimura, Stephen L, Nakayama, Katsutoshi, Kuwano, Kazuyoshi

“…Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis…”
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Metformin attenuates lung fibrosis development via NOX4 suppression by Sato, Nahoko, Takasaka, Naoki, Yoshida, Masahiro, Tsubouchi, Kazuya, Minagawa, Shunsuke, Araya, Jun, Saito, Nayuta, Fujita, Yu, Kurita, Yusuke, Kobayashi, Kenji, Ito, Saburo, Hara, Hiromichi, Kadota, Tsukasa, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Utsumi, Hirofumi, Wakui, Hiroshi, Kojima, Jun, Numata, Takanori, Kaneko, Yumi, Odaka, Makoto, Morikawa, Toshiaki, Nakayama, Katsutoshi, Kohrogi, Hirotsugu, Kuwano, Kazuyoshi

“…Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis…”
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Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis by Kobayashi, Kenji, Araya, Jun, Minagawa, Shunsuke, Hara, Hiromichi, Saito, Nayuta, Kadota, Tsukasa, Sato, Nahoko, Yoshida, Masahiro, Tsubouchi, Kazuya, Kurita, Yusuke, Ito, Saburo, Fujita, Yu, Takasaka, Naoki, Utsumi, Hirofumi, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Wakui, Hiroshi, Kojima, Jun, Shimizu, Kenichiro, Numata, Takanori, Kawaishi, Makoto, Kaneko, Yumi, Asano, Hisatoshi, Yamashita, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nakayama, Katsutoshi, Kuwano, Kazuyoshi

“…Fibroblastic foci, known to be the leading edge of fibrosis development in idiopathic pulmonary fibrosis (IPF), are composed of fibrogenic myofibroblasts…”
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Subinterlobular Pleural Location Is a Risk Factor for Pneumothorax After Bronchoscopy by Chino, Haruka, Iikura, Motoyasu, Saito, Nayuta, Sato, Nahoko, Suzuki, Manabu, Ishii, Satoru, Morino, Eriko, Naka, Go, Takasaki, Jin, Izumi, Shinyu, Hojo, Masayuki, Takeda, Yuichiro, Sugiyama, Haruhito

“…Pneumothorax is one of the most important complications after bronchoscopy. This study was conducted to determine the risk factors for post-bronchoscopy…”
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A survival case of invasive thymoma accompanied by acute fulminant myocarditis by Saito, Nayuta, Shimizu, Kenichiro, Kawaishi, Makoto, Araya, Jun, Nakayama, Katsutoshi, Kuwano, Kazuyoshi

“…Thymomas are associated with a wide spectrum of autoimmune paraneoplastic diseases. Here we report the case of 31‐year‐old male with invasive thymoma,…”
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