Search Results - "Sainz, Alva G."

PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species by Warfel, Noel A, Sainz, Alva G, Song, Jin H, Kraft, Andrew S

“…Intratumoral hypoxia is a significant obstacle to the successful treatment of solid tumors, and it is highly correlated with metastasis, therapeutic…”
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Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions by Hepokoski, Mark L, Odish, Mazen, Lam, Michael T, Coufal, Nicole G, Rolfsen, Mark L, Shadel, Gerald S, Moyzis, Alexandra G, Sainz, Alva G, Takiar, Puja G, Patel, Sagar, Leonard, Austin J, Samandari, Negin, Hansen, Emily, Trescott, Samantha, Nguyen, Celina, Jepsen, Kristen, Cutter, Gary, Gillespie, Mark N, Spragg, Roger G, Sasik, Roman, Ix, Joachim H

“…Increased plasma mitochondrial DNA concentrations are associated with poor outcomes in multiple critical illnesses, including COVID-19. However, current…”
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Mitochondrial DNA: cellular genotoxic stress sentinel by Wu, Zheng, Sainz, Alva G., Shadel, Gerald S.

“…High copy number, damage prone, and lean on repair mechanisms are unique features of mitochondrial DNA (mtDNA) that are hard to reconcile with its essentiality…”
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Apoptotic stress causes mtDNA release during senescence and drives the SASP by Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.

“…Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP) 1 …”
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Manipulating mitochondrial electron flow enhances tumor immunogenicity by Mangalhara, Kailash Chandra, Varanasi, Siva Karthik, Johnson, Melissa A, Burns, Mannix J, Rojas, Gladys R, Esparza Moltó, Pau B, Sainz, Alva G, Tadepalle, Nimesha, Abbott, Keene L, Mendiratta, Gaurav, Chen, Dan, Farsakoglu, Yagmur, Kunchok, Tenzin, Hoffmann, Filipe Araujo, Parisi, Bianca, Rincon, Mercedes, Vander Heiden, Matthew G, Bosenberg, Marcus, Hargreaves, Diana C, Kaech, Susan M, Shadel, Gerald S

“…Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the…”
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Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents by Casillas, Andrea L, Toth, Rachel K, Sainz, Alva G, Singh, Neha, Desai, Ankit A, Kraft, Andrew S, Warfel, Noel A

“…Patients develop resistance to antiangiogenic drugs, secondary to changes in the tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases…”
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Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors by Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A.

“…Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive…”
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Mitochondrial DNA stress signalling protects the nuclear genome by Wu, Zheng, Oeck, Sebastian, West, A. Phillip, Mangalhara, Kailash C., Sainz, Alva G., Newman, Laura E., Zhang, Xiao-Ou, Wu, Lizhen, Yan, Qin, Bosenberg, Marcus, Liu, Yanfeng, Sulkowski, Parker L., Tripple, Victoria, Kaech, Susan M., Glazer, Peter M., Shadel, Gerald S.

“…The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential…”
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Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP by Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.

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Direct phosphorylation and stabilization of HIF-1[alpha] by PIM1 kinase drives angiogenesis in solid tumors by Casillas, Andrea L, Chauhan, Shailender S, Toth, Rachel K, Sainz, Alva G, Clements, Amber N, Jensen, Corbin C, Langlais, Paul R, Miranti, Cindy K, Cress, Anne E, Warfel, Noel A

“…Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive…”
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Hypoxia-inducible PIM kinase expression promotes resistance to anti-angiogenic agents by Casillas, Andrea L., Toth, Rachel K., Sainz, Alva G., Singh, Neha, Desai, Ankit A., Kraft, Andrew S., Warfel, Noel A.

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Abstract LB-024: PIM kinase inhibitors selectively kill hypoxic cancer cells by reducing Nrf2 activity and increasing reactive oxygen species by Sainz, Alva G., Song, Jin H., Kraft, Andrew S., Warfel, Noel A.

“…Abstract Prostate cancer (PCa) is the leading cause of cancer death in men worldwide. Patients diagnosed with metastatic prostate cancer initially respond to…”
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Identification and Characterization of Novel Mediators of Intergenomic Signaling by Sainz Castillo, Alva G

“…Mitochondria are bacteria-derived double-membraned organelles that perform vital cellular functions, including ATP production, apoptosis, and regulation of…”
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