Search Results - "Sainson, Richard C.A."

Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo by LI, Ji-Liang, SAINSON, Richard C. A, HARRIS, Adrian L, WEN SHI, LEEK, Russell, HARRINGTON, Laura S, PREUSSER, Matthias, BISWAS, Swethajit, TURLEY, Helen, HEIKAMP, Emily, HAINFELLNER, Johannes A

“…The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often…”
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Regulation of the anti-tumour immune response by cancer-associated fibroblasts by Harper, James, Sainson, Richard C.A

“…Abstract The microenvironment of established tumours is often immunosuppressed, and this allows tumours to grow and disseminate without being eliminated by the…”
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Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery by Mosely, Suzanne I S, Prime, John E, Sainson, Richard C A, Koopmann, Jens-Oliver, Wang, Dennis Y Q, Greenawalt, Danielle M, Ahdesmaki, Miika J, Leyland, Rebecca, Mullins, Stefanie, Pacelli, Luciano, Marcus, Danielle, Anderton, Judith, Watkins, Amanda, Coates Ulrichsen, Jane, Brohawn, Philip, Higgs, Brandon W, McCourt, Matthew, Jones, Hazel, Harper, James A, Morrow, Michelle, Valge-Archer, Viia, Stewart, Ross, Dovedi, Simon J, Wilkinson, Robert W

“…Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these models are still not…”
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A Conserved Mechanism for Steroid Receptor Translocation to the Plasma Membrane by Pedram, Ali, Razandi, Mahnaz, Sainson, Richard C.A., Kim, Jin K., Hughes, Christopher C., Levin, Ellis R.

“…Multiple steroid receptors (SR) have been proposed to localize to the plasma membrane. Some structural elements for membrane translocation of the estrogen…”
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DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo by LI, Ji-Liang, SAINSON, Richard C. A, WU, Herren, CHOWDHURY, Partha S, RUSSELL, Angela J, MONTGOMERY, Craig P, POULSOM, Richard, HARRIS, Adrian L, EIN OON, Chern, TURLEY, Helen, LEEK, Russell, SHELDON, Helen, BRIDGES, Esther, SHI, Wen, SNELL, Cameron, BOWDEN, Emma T

“…Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate…”
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Downregulation of Manic fringe impedes angiogenesis and cell migration of renal carcinoma by Cheng, Wei Kang, Oon, Chern Ein, Kaur, Gurjeet, Sainson, Richard C.A., Li, Ji-Liang

“…Clear cell renal cell carcinoma (ccRCC) is a highly angiogenic cancer. Manic fringe (MFng) is elevated in ccRCC compared to the normal kidney. However, its…”
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Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells by Harrington, Laura S., Sainson, Richard C.A., Williams, Cassin Kimmel, Taylor, Jennifer M., Shi, Wen, Li, Ji-Liang, Harris, Adrian L.

“…The Notch ligand, Dll4, is essential for angiogenesis during embryonic vascular development and is involved in tumour angiogenesis. Several recent publications…”
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Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? by Sainson, Richard C.A, Harris, Adrian L

“…Since the early 1970s, the dogma postulating that blocking tumour angiogenesis can inhibit tumour growth has been accepted widely and has resulted in the…”
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Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1 by Nakatsu, Martin N., Sainson, Richard C.A., Aoto, Jason N., Taylor, Kevin L., Aitkenhead, Mark, Pérez-del-Pulgar, Sofía, Carpenter, Philip M., Hughes, Christopher C.W.

“…Angiogenesis is a multistep process of critical importance both in development and in physiological and pathophysiological processes in the adult. It involves…”
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Regulation of CXCR4 by the Notch Ligand Delta-like 4 in Endothelial Cells by WILLIAMS, Cassin Kimmel, SEGARRA, Marta, DE LA LUZ SIERRA, Maria, SAINSON, Richard C. A, TOSATO, Giovanna, HARRIS, Adrian L

“…Gene-targeting studies have shown that Delta-like 4 (Dll4) is required for normal embryonic vascular remodeling, but the mechanisms underlying Dll4 regulatory…”
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Characterization and application of two RANK-specific antibodies with different biological activities by Chypre, Mélanie, Seaman, Jonathan, Cordeiro, Olga G, Willen, Laure, Knoop, Kathryn A, Buchanan, Andrew, Sainson, Richard C.A, Williams, Ifor R, Yagita, Hideo, Schneider, Pascal, Mueller, Christopher G

“…Highlights • Two RANK (TNFRSF11a)-specific monoclonal antibodies are characterized. • Both recognize human and mouse RANK with high specificity and affinity. •…”
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New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes by Sheldon, Helen, Heikamp, Emily, Turley, Helen, Dragovic, Rebecca, Thomas, Peter, Oon, Chern Ein, Leek, Russell, Edelmann, Mariola, Kessler, Benedikt, Sainson, Richard C.A., Sargent, Ian, Li, Ji-Liang, Harris, Adrian L.

“…Notch signaling is an evolutionary conserved pathway that is mediated by cell-cell contact. It is involved in a variety of developmental processes and has an…”
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A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance by Yap, Timothy A, LoRusso, Patricia M, Wong, Deborah J, Hu-Lieskovan, Siwen, Papadopoulos, Kyriakos P, Holz, Josefin-Beate, Grabowska, Urszula, Gradinaru, Cristian, Leung, Kin-Mei, Marshall, Sylwia, Reader, Claire S, Russell, Roslin, Sainson, Richard C A, Seal, Claire J, Shepherd, Christopher J, Germaschewski, Fiona, Gliddon, Daniel, Stern, Omer, Young, Lesley, Brewis, Neil, Kayitalire, Louis, Morrow, Michelle

“…This phase 1 study (NCT03440437) evaluated the safety, tolerability, pharmacokinetics (PK), and activity of FS118, a bispecific antibody-targeting LAG-3 and…”
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A phase 1/2 open-label study of KY1044, an anti-ICOS antibody with dual mechanism of action, as single agent and in combination with atezolizumab, in adult patients with advanced malignancies by Patel, Manish R., Naing, Aung, Burris III, Howard A., Lin, Chia-Chi, Curigliano, Giuseppe, Thistlethwaite, Fiona, Minchom, Anna Rachel, Ascierto, Paolo Antonio, De Braud, Filippo G., Cecchini, Michael, Hanekom, Wouter, Sainson, Richard C.A, Wilson, Rosamund J, Quaratino, Sonia

“…Abstract only 2624 Background: KY1044, is a fully human IgG1 anti ICOS antibody designed to stimulate Teffs and to deplete ICOS high Tregs in the tumor…”
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Diffusion limits of an in vitro thick prevascularized tissue by Griffith, Craig K, Miller, Cheryl, Sainson, Richard C A, Calvert, Jay W, Jeon, Noo Li, Hughes, Christopher C W, George, Steven C

“…Although tissue engineering promises to replace or restore lost function to nearly every tissue in the body, successful applications are currently limited to…”
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TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype by Sainson, Richard C.A., Johnston, Douglas A., Chu, Henry C., Holderfield, Matthew T., Nakatsu, Martin N., Crampton, Steven P., Davis, Jaeger, Conn, Erin, Hughes, Christopher C.W.

“…Pathological angiogenesis associated with wound healing often occurs subsequent to an inflammatory response that includes the secretion of cytokines such as…”
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KY1044 to target the ICOS pathways inducing intratumoral Treg depletion and agonism of effector T cells: Preliminary pharmacodynamic markers from a phase 1/2 multicenter trial by Lin, Chia-Chi, Naing, Aung, Patel, Manish R., Burris III, Howard A., Curigliano, Giuseppe, Thistlethwaite, Fiona, Minchom, Anna Rachel, Ascierto, Paolo Antonio, De Braud, Filippo G., Eder, Joseph Paul, Wake, Matthew, Palu, Cintia Cristina, Newton, Anthea Louise, Deantonio, Cecilia, Hanekom, Wouter, Sainson, Richard C.A, Quaratino, Sonia

“…Abstract only 2626 Background: Inducible T-cell co-stimulator (ICOS) is an important co-stimulatory receptor on effector T cells (Teffs) that also promotes…”
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Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent by Xie, Bangwen, Tomaszewski, Michal R, Neves, André A, Ros, Susana, Hu, De-En, McGuire, Sarah, Mullins, Stefanie R, Tice, David, Sainson, Richard C A, Bohndiek, Sarah E, Wilkinson, Robert W, Brindle, Kevin M

“…The development of new treatments and their deployment in the clinic may be assisted by imaging methods that allow an early assessment of treatment response in…”
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Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth by Oon, Chern Ein, Bridges, Esther, Sheldon, Helen, Sainson, Richard C A, Jubb, Adrian, Turley, Helen, Leek, Russell, Buffa, Francesca, Harris, Adrian L, Li, Ji-Liang

“…Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal…”
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Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis by Sainson, Richard C. A, Aoto, Jason, Nakatsu, Martin N, Holderfield, Matthew, Conn, Erin, Koller, Erich, Hughes, Christopher C. W

“…ABSTRACTThe requirement for notch signaling during vascular development is well‐documented but poorly understood. Embryonic and adult endothelial cells (EC)…”
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