Search Results - "Saini, Sarbjit S."

Urticaria and basophils by Saini, Sarbjit S.

“…Chronic spontaneous urticaria (CSU) is a common skin disease without an etiology in the vast majority of cases. The similarity of symptoms and pathology to…”
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Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation by MacGlashan, Donald W., MD, PhD, Saini, Sarbjit S., MD

“…Background Treatment of allergic patients with omalizumab results in a paradoxical increase in their basophil histamine release (HR) response ex vivo to…”
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Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab by MacGlashan, Donald W., MD, PhD, Saini, Sarbjit S., MD

“…[...]the biological changes that occur during treatment with omalizumab have suggested that changes in basophil IgE-mediated reactivity occur faster than…”
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Emerging Therapies in Chronic Spontaneous Urticaria by Min, Taek Ki, Saini, Sarbjit S

“…Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist…”
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Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy by Savage, Jessica H., MD, MHS, Courneya, Jean-Paul, MS, Sterba, Patricia M., MS, MacGlashan, Donald W., MD, PhD, Saini, Sarbjit S., MD, Wood, Robert A., MD

“…Background Monoclonal antibodies directed at IgE demonstrate clinical efficacy in subjects with peanut allergy, but previous studies have not addressed the…”
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Serum IgE as an immunological marker to predict response to omalizumab treatment in symptomatic chronic urticaria by Straesser, Matthew D., Oliver, Eric, Palacios, Thamiris, Kyin, Timothy, Patrie, James, Borish, Larry, Saini, Sarbjit S., Lawrence, Monica G.

“…First-line therapies for CU are high-dose H1 and H2 antihistamines along with leukotriene receptor antagonists. [...]none of the aforementioned works…”
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Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge by Eckman, John A., MD, Sterba, Patricia M., MS, Kelly, Denise, RN, BSN, Alexander, Val, BS, Liu, Mark C., MD, Bochner, Bruce S., MD, MacGlashan, Donald W., MD, PhD, Saini, Sarbjit S., MD

“…Background Omalizumab treatment suppresses FcϵRI expression faster on blood basophils than skin mast cells. Objective We used omalizumab to elucidate the…”
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Evaluating the minimally important difference of the urticaria activity score and other measures of disease activity in patients with chronic idiopathic urticaria by Mathias, Susan D., MPH, Crosby, Ross D., PhD, Zazzali, James L., PhD, Maurer, Marcus, MD, Saini, Sarbjit S., MD

“…Abstract Background The Urticaria Activity Score (UAS) is a widely used patient-reported outcome measure for patients with chronic idiopathic urticaria (CIU)…”
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IgE antibody-specific activity in human allergic disease by Hamilton, Robert G., MacGlashan, Donald W., Saini, Sarbjit S.

“…IgE antibody concentration, affinity, clonality and specific activity (also known as the allergen-specific IgE to total IgE ratio) influence the translation of…”
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Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factors by MacGlashan, Donald W., MD, PhD, Savage, Jessica H., MD, Wood, Robert A., MD, Saini, Sarbjit S., MD

“…Background A recent study of subjects with peanut allergy treated with omalizumab generated some results that were concordant with a study of subjects with cat…”
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Basophil Phenotypes in Chronic Idiopathic Urticaria in Relation to Disease Activity and Autoantibodies by Eckman, John A., Hamilton, Robert G., Gober, Laura M., Sterba, Patricia M., Saini, Sarbjit S.

“…Potentially pathogenic IgG autoantibodies to IgE or its receptor, FcεRIα, have been detected in ~40% of chronic idiopathic urticaria (CIU) patients. CIU…”
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Efficacy and safety of sulfasalazine in patients with chronic idiopathic urticaria by Orden, Roy Anthony, MD, Timble, Hersha, Saini, Sarbjit S., MD

“…Abstract Background There are limited data regarding alternative treatments for antihistamine refractory chronic idiopathic urticaria (CIU). Patients with…”
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Chronic Idiopathic Urticaria: Systemic Complaints and Their Relationship with Disease and Immune Measures by Doong, Judy C., BS, Chichester, Kris, MS, Oliver, Eric T., MD, Schwartz, Lawrence B., MD, PhD, Saini, Sarbjit S., MD

“…Background Patients with chronic idiopathic urticaria (CIU)/chronic spontaneous urticaria sometimes report systemic complaints (SCs). Objective We sought to…”
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Dupilumab Reduces Urticaria Activity, Itch, and Hives in Patients with Chronic Spontaneous Urticaria Regardless of Baseline Serum Immunoglobulin E Levels by Maurer, Marcus, Casale, Thomas B., Saini, Sarbjit S., Ben-Shoshan, Moshe, Laws, Elizabeth, Maloney, Jennifer, Bauer, Deborah, Radin, Allen, Makhija, Melanie

“…Introduction In chronic spontaneous urticaria (CSU), interleukin (IL)-4 and IL-13 may promote mast cell activation directly via IL-4 receptor expression, or…”
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Pharmacokinetic equivalence of CT‐P39 and reference omalizumab in healthy individuals: A randomised, double‐blind, parallel‐group, Phase 1 trial by Maurer, Marcus, Saini, Sarbjit S., McLendon, Kristi, Wabnitz, Paul, Kim, Sunghyun, Ahn, Keumyoung, Kim, Suyoung, Lee, Sewon, Grattan, Clive

“…Background CT‐P39 is being developed as a biosimilar of reference omalizumab. This study aimed to assess the pharmacokinetic equivalence of CT‐P39 to European…”
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Frequency and Characteristics of Systemic Complaints Among Chronic Idiopathic/Spontaneous Urticaria Patients by Doong, Judy, BS, Oliver, Eric, MD, Saini, Sarbjit S., MD, FAAAAI

“…The SC group, compared to NSC group, had significantly greater disease duration (53% SC vs 30.8% NSC had >4 years duration), emergency department visits (16.5%…”
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Regulation of Syk kinase and FcRβ expression in human basophils during treatment with omalizumab by Zaidi, Asifa K., PhD, Saini, Sarbjit S., MD, MacGlashan, Donald W., MD, PhD

“…Background In human basophils from different subjects, maximum IgE-mediated histamine release and the level of Syk protein expression correlate well. Recent…”
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Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy by Casale, Thomas B., MD, Bernstein, Jonathan A., MD, Maurer, Marcus, MD, Saini, Sarbjit S., MD, Trzaskoma, Benjamin, MS, Chen, Hubert, MD, Grattan, Clive E., MA, MD, FRCP, Gimenéz-Arnau, Ana, MD, PhD, Kaplan, Allen P., MD, Rosén, Karin, MD, PhD

“…Background Data from the 3 omalizumab pivotal trials in patients with chronic idiopathic urticaria/chronic spontaneous urticaria (CIU/CSU) represent the…”
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Emerging Therapies in Chronic Spontaneous Urticaria by Min, Taek Ki, Saini, Sarbjit S.

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Sensitization Profile of Individuals to Shellfish in the Chesapeake Bay Area by Ali, Aishah, MD, Hamilton, Robert G., PhD, D.ABMLI, FAAAAI, Saini, Sarbjit S., MD, FAAAAI

“…IgE antibody responses to crustacean allergens (shrimp, crab, and lobster, n=1341) were tested more often than those to mollusks (clam, oyster, scallop,…”
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