Search Results - "Saini, Rajneet Kaur"

Unveiling the inhibitory mechanism of peptidomimetic inhibitor against Aβ42 aggregation and protofibril disaggregation by molecular dynamics by Kaur, Rajdeep, Kaur Saini, Rajneet, Singh, Pritpal, Goyal, Bhupesh

“…The peptidomimetic compound C1 stabilized the non-aggregation-prone helical conformation of the Aβ42 monomer. C1 destabilized the S-shaped Aβ42 protofibril…”
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Impact of Mutations on the Conformational Transition from α‑Helix to β‑Sheet Structures in Arctic-Type Aβ40: Insights from Molecular Dynamics Simulations by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Deepti, Goyal, Bhupesh

“…The amyloid-β (Aβ) protein aggregation into toxic oligomers and fibrils has been recognized as a key player in the pathogenesis of Alzheimer’s disease. Recent…”
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How L17A/F19A Double Mutation Diminish Aβ40 Aggregation in Alzheimer's Disease: Key Insights from Molecular Dynamics Simulations by Saini, Rajneet Kaur

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Targeting Human Islet Amyloid Polypeptide Aggregation and Toxicity in Type 2 Diabetes: An Overview of Peptide-Based Inhibitors by Saini, Rajneet Kaur, Goyal, Deepti, Goyal, Bhupesh

“…Type 2 diabetes (T2D) is a chronic metabolic disease characterized by insulin resistance and a progressive loss of pancreatic islet β-cell mass, which leads to…”
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Molecular insights into Aβ42 protofibril destabilization with a fluorinated compound D744: A molecular dynamics simulation study by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Bhupesh

“…The aggregation of amyloid β‐peptide (Aβ42) into toxic oligomers, fibrils, has been identified as a key process in Alzheimer's disease (AD) progression. The…”
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Insights into the inhibitory mechanism of a resveratrol and clioquinol hybrid against Aβ42 aggregation and protofibril destabilization: A molecular dynamics simulation study by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Deepti, Goyal, Bhupesh

“…Amyloid-β (Aβ) peptide instinctively aggregate and form plaques in the brain of Alzheimer's disease (AD) patients. At present, there is no cure or treatment…”
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Effect of Piedmont mutation (L34V) on the structure, dynamics, and aggregation of Alzheimer’s Aβ40 peptide by Saini, Rajneet Kaur, Thakur, Hema, Goyal, Bhupesh

“…The amyloid-β (Aβ) aggregation in the brain has been associated with the development of Alzheimer’s disease (AD). The previous studies have reported that…”
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Impact of K16A and K28A mutation on the structure and dynamics of amyloid-β42 peptide in Alzheimer's disease: key insights from molecular dynamics simulations by Shuaib, Suniba, Saini, Rajneet Kaur, Goyal, Deepti, Goyal, Bhupesh

“…The aggregation of amyloid-β 42 (Aβ 42 ) peptide into toxic oligomers and fibrils is a key step in the Alzheimer disease pathogenesis. The recent studies…”
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Molecular insights into the effect L17A/F19A double mutation on the structure and dynamics of Aβ40: A molecular dynamics simulation study by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Deepti, Goyal, Bhupesh

“…The aggregation of amyloid‐β (Aβ) peptide has been associated with the pathogenesis of Alzheimer disease. The recent studies highlighted that L17A/F19A double…”
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Molecular insights into the effect L17A/F19A double mutation on the structure and dynamics of Aβ 40 : A molecular dynamics simulation study by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Deepti, Goyal, Bhupesh

“…The aggregation of amyloid-β (Aβ) peptide has been associated with the pathogenesis of Alzheimer disease. The recent studies highlighted that L17A/F19A double…”
Get full text

Molecular insights into Aβ 42 protofibril destabilization with a fluorinated compound D744: A molecular dynamics simulation study by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Bhupesh

“…The aggregation of amyloid β-peptide (Aβ ) into toxic oligomers, fibrils, has been identified as a key process in Alzheimer's disease (AD) progression. The…”
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Molecular insights into A[beta]42 protofibril destabilization with a fluorinated compound D744: A molecular dynamics simulation study by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Bhupesh

“…The aggregation of amyloid [beta]-peptide (A[beta]42) into toxic oligomers, fibrils, has been identified as a key process in Alzheimer's disease (AD)…”
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Impact of K16A and K28A mutation on the structure and dynamics of amyloid-β 42 peptide in Alzheimer's disease: key insights from molecular dynamics simulations by Shuaib, Suniba, Saini, Rajneet Kaur, Goyal, Deepti, Goyal, Bhupesh

“…The aggregation of amyloid-β (Aβ ) peptide into toxic oligomers and fibrils is a key step in the Alzheimer disease pathogenesis. The recent studies highlighted…”
Get full text

Insights into the inhibitory mechanism of a resveratrol and clioquinol hybrid against Aβ 42 aggregation and protofibril destabilization: A molecular dynamics simulation study by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Deepti, Goyal, Bhupesh

“…Amyloid-β (Aβ) peptide instinctively aggregate and form plaques in the brain of Alzheimer's disease (AD) patients. At present, there is no cure or treatment…”
Get full text

Effect of Piedmont mutation (L34V) on the structure, dynamics, and aggregation of Alzheimer's Aβ 40 peptide by Saini, Rajneet Kaur, Thakur, Hema, Goyal, Bhupesh

“…The amyloid-β (Aβ) aggregation in the brain has been associated with the development of Alzheimer's disease (AD). The previous studies have reported that…”
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Insights into the Inhibitory Mechanism of Dicyanovinyl‐Substituted J147 Derivative against Aβ42 Aggregation and Protofibril Destabilization: A Molecular Dynamics Simulation Study by Shuaib, Suniba, Saini, Rajneet Kaur, Goyal, Deepti, Goyal, Bhupesh

“…The self‐assembly of amyloid β‐peptide (Aβ) into β‐sheet enriched fibrillar aggregates is associated with Alzheimer's disease (AD). A disease modifying therapy…”
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Impact of Mutations on the Conformational Transition from α-Helix to β-Sheet Structures in Arctic-Type Aβ 40 : Insights from Molecular Dynamics Simulations by Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Deepti, Goyal, Bhupesh

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Insights into the Inhibitory Mechanism of Dicyanovinyl‐Substituted J147 Derivative against Aβ 42 Aggregation and Protofibril Destabilization: A Molecular Dynamics Simulation Study by Shuaib, Suniba, Saini, Rajneet Kaur, Goyal, Deepti, Goyal, Bhupesh

“…The self‐assembly of amyloid β‐peptide (Aβ) into β‐sheet enriched fibrillar aggregates is associated with Alzheimer's disease (AD). A disease modifying therapy…”
Get full text