Search Results - "Saini, Massimo"

Circulating Tumor Cell-Neutrophil Tango along the Metastatic Process by Saini, Massimo, Szczerba, Barbara M, Aceto, Nicola

“…The crosstalk between cancer cells and the immune system is crucial for disease progression and its therapeutic targeting is providing exciting results, in…”
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A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice by Zonari, Erika, Pucci, Ferdinando, Saini, Massimo, Mazzieri, Roberta, Politi, Letterio S., Gentner, Bernhard, Naldini, Luigi

“…A productive immune response requires transient upregulation of the microRNA miR-155 in hematopoietic cells mediating innate and adaptive immunity. In order to…”
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Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion by Lechman, Eric R., Gentner, Bernhard, van Galen, Peter, Giustacchini, Alice, Saini, Massimo, Boccalatte, Francesco E., Hiramatsu, Hidefumi, Restuccia, Umberto, Bachi, Angela, Voisin, Veronique, Bader, Gary D., Dick, John E., Naldini, Luigi

“…Lifelong blood cell production is governed through the poorly understood integration of cell-intrinsic and -extrinsic control of hematopoietic stem cell (HSC)…”
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Single cell polarity in liquid phase facilitates tumour metastasis by Lorentzen, Anna, Becker, Paul F., Kosla, Jan, Saini, Massimo, Weidele, Kathrin, Ronchi, Paolo, Klein, Corinna, Wolf, Monika J., Geist, Felix, Seubert, Bastian, Ringelhan, Marc, Mihic-Probst, Daniela, Esser, Knud, Roblek, Marko, Kuehne, Felix, Bianco, Gaia, O’Connor, Tracy, Müller, Quentin, Schuck, Kathleen, Lange, Sebastian, Hartmann, Daniel, Spaich, Saskia, Groß, Olaf, Utikal, Jochen, Haferkamp, Sebastian, Sprick, Martin R., Damle-Vartak, Amruta, Hapfelmeier, Alexander, Hüser, Norbert, Protzer, Ulrike, Trumpp, Andreas, Saur, Dieter, Vartak, Nachiket, Klein, Christoph A., Polzer, Bernhard, Borsig, Lubor, Heikenwalder, Mathias

“…Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established,…”
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Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway by Tesio, Melania, Tang, Yilang, Müdder, Katja, Saini, Massimo, von Paleske, Lisa, Macintyre, Elizabeth, Pasparakis, Manolis, Waisman, Ari, Trumpp, Andreas

“…The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic stem cells (HSCs) during adult homeostasis. However the molecular…”
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ICAM-1 on Breast Cancer Cells Suppresses Lung Metastasis but Is Dispensable for Tumor Growth and Killing by Cytotoxic T Cells by Regev, Ofer, Kizner, Marina, Roncato, Francesco, Dadiani, Maya, Saini, Massimo, Castro-Giner, Francesc, Yajuk, Olga, Kozlovski, Stav, Levi, Nehora, Addadi, Yoseph, Golani, Ofra, Ben-Dor, Shifra, Granot, Zvi, Aceto, Nicola, Alon, Ronen

“…Breast tumors and their derived circulating cancer cells express the leukocyte β integrin ligand Intercellular adhesion molecule 1 (ICAM-1). We found that…”
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Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients by Baccelli, Irène, Stenzinger, Albrecht, Vogel, Vanessa, Pfitzner, Berit Maria, Klein, Corinna, Wallwiener, Markus, Scharpff, Martina, Saini, Massimo, Holland-Letz, Tim, Sinn, Hans-Peter, Schneeweiss, Andreas, Denkert, Carsten, Weichert, Wilko, Trumpp, Andreas

“…Although luminal-type primary breast cancer can be efficiently treated, development of metastatic disease remains a significant clinical problem. We have…”
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To Be Taken in Count: Prostatic Tumor Cells Break Free upon Needle Biopsy by Saini, Massimo, Aceto, Nicola

“…CTC counts provided by CellSearch are one of the most accurate surrogates for survival end points in prostate cancer clinical trials (7), as the hematogenous…”
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The metastatic spread of breast cancer accelerates during sleep by Diamantopoulou, Zoi, Castro-Giner, Francesc, Schwab, Fabienne Dominique, Foerster, Christiane, Saini, Massimo, Budinjas, Selina, Strittmatter, Karin, Krol, Ilona, Seifert, Bettina, Heinzelmann-Schwarz, Viola, Kurzeder, Christian, Rochlitz, Christoph, Vetter, Marcus, Weber, Walter Paul, Aceto, Nicola

“…The metastatic spread of cancer is achieved by the haematogenous dissemination of circulating tumour cells (CTCs). Generally, however, the temporal dynamics…”
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Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay by Baccelli, Irène, Schneeweiss, Andreas, Riethdorf, Sabine, Stenzinger, Albrecht, Schillert, Anja, Vogel, Vanessa, Klein, Corinna, Saini, Massimo, Bäuerle, Tobias, Wallwiener, Markus, Holland-Letz, Tim, Höfner, Thomas, Sprick, Martin, Scharpff, Martina, Marmé, Frederik, Sinn, Hans Peter, Pantel, Klaus, Weichert, Wilko, Trumpp, Andreas

“…A xenograft assay facilitates identification of metastasis-initiating cells in the blood of individuals with breast cancer. It has been hypothesized that…”
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Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation by Campbell, Nathaniel R., Rao, Anjali, Hunter, Miranda V., Sznurkowska, Magdalena K., Briker, Luzia, Zhang, Maomao, Baron, Maayan, Heilmann, Silja, Deforet, Maxime, Kenny, Colin, Ferretti, Lorenza P., Huang, Ting-Hsiang, Perlee, Sarah, Garg, Manik, Nsengimana, Jérémie, Saini, Massimo, Montal, Emily, Tagore, Mohita, Newton-Bishop, Julia, Middleton, Mark R., Corrie, Pippa, Adams, David J., Rabbie, Roy, Aceto, Nicola, Levesque, Mitchell P., Cornell, Robert A., Yanai, Itai, Xavier, Joao B., White, Richard M.

“…Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus invasive (INV) subpopulations that represent a “go or grow” trade-off;…”
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Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer by Magnani, Luca, Frigè, Gianmaria, Gadaleta, Raffaella Maria, Corleone, Giacomo, Fabris, Sonia, Kempe, Hermannus, Verschure, Pernette J, Barozzi, Iros, Vircillo, Valentina, Hong, Sung-Pil, Perone, Ylenia, Saini, Massimo, Trumpp, Andreas, Viale, Giuseppe, Neri, Antonino, Ali, Simak, Colleoni, Marco Angelo, Pruneri, Giancarlo, Minucci, Saverio

“…Saverio Minucci, Giancarlo Pruneri, Luca Magnani and colleagues identify acquired CYP19A1 amplification as a mechanism of resistance to aromatase inhibitors in…”
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Genetic Engineering of Hematopoietic Progenitor Stem Cells for Targeted IFN-α Immunotherapy Reprogramming the Solid Tumor Microenvironment: A First-in-Man Study in Glioblastoma Multiforme (NCT03866109) by Farina, Francesca, Gentner, Bernhard, Finocchiaro, Gaetano, Eoli, Marica, Capotondo, Alessia, Anghileri, Elena, Barcella, Matteo, Brambilla, Valentina, Carrabba, Matteo Giovanni, Cuccarini, Valeria, D'Alessandris, Quintino Giorgio, Di Meco, Francesco, Ferla, Valeria, Ferroli, Paolo, Gagliardi, Filippo, Legnani, Federico Giuseppe, Mazzoleni, Stefania, Olivi, Alessandro, Pallini, Roberto, Saini, Massimo, Mullen, Karen, Naldini, Luigi, Russo, Carlo, Ciceri, Fabio

“…Background and methods. TEM-GBM is a Phase 1/2a dose-escalating non-randomized open label study, involving a single intravenous injection of Temferon. Temferon…”
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Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer by Saini, Massimo, Schmidleitner, Laura, Moreno, Helena Domínguez, Donato, Elisa, Falcone, Mattia, Bartsch, Johanna M., Klein, Corinna, Vogel, Vanessa, Würth, Roberto, Pfarr, Nicole, Espinet, Elisa, Lehmann, Mareike, Königshoff, Melanie, Reitberger, Manuel, Haas, Simon, Graf, Elisabeth, Schwarzmayr, Thomas, Strom, Tim-Matthias, Spaich, Saskia, Sütterlin, Marc, Schneeweiss, Andreas, Weichert, Wilko, Schotta, Gunnar, Reichert, Maximilian, Aceto, Nicola, Sprick, Martin R., Trumpp, Andreas, Scheel, Christina H.

“…The acquisition of mesenchymal traits is considered a hallmark of breast cancer progression. However, the functional relevance of epithelial-to-mesenchymal…”
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The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features by Aloia, Andrea, Petrova, Evgeniya, Tomiuk, Stefan, Bissels, Ute, Déas, Olivier, Saini, Massimo, Zickgraf, Franziska Maria, Wagner, Steve, Spaich, Saskia, Sütterlin, Marc, Schneeweiss, Andreas, Reitberger, Manuel, Rüberg, Silvia, Gerstmayer, Bernhard, Agorku, David, Knöbel, Sebastian, Terranegra, Annalisa, Falleni, Monica, Soldati, Laura, Sprick, Martin Ronald, Trumpp, Andreas, Judde, Jean-Gabriel, Bosio, Andreas, Cairo, Stefano, Hardt, Olaf

“…Chemotherapy resistance resulting in incomplete pathologic response is associated with high risk of metastasis and early relapse in breast cancer. The aim of…”
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Sustained prognostic impact of circulating tumor cell status and kinetics upon further progression of metastatic breast cancer by Jauch, Sarah F., Riethdorf, Sabine, Sprick, Martin R., Schütz, Florian, Schönfisch, Birgitt, Brucker, Sara Y., Deutsch, Thomas M., Nees, Juliane, Saini, Massimo, Becker, Lisa M., Burwinkel, Barbara, Sinn, Peter, Marmé, Frederik, Pantel, Klaus, Jäger, Dirk, Sohn, Christof, Trumpp, Andreas, Wallwiener, Markus, Schneeweiss, Andreas

“…Purpose Serial longitudinal enumeration of circulating tumor cells (CTCs) has shown its prognostic value on progression-free survival and overall survival (OS)…”
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Hematopoietic stem cell quiescence and function are controlled by the CYLD–TRAF2–p38MAPK pathway by Tesio, Melania, Tang, Yilang, Müdder, Katja, Saini, Massimo, von Paleske, Lisa, Macintyre, Elizabeth, Pasparakis, Manolis, Waisman, Ari, Trumpp, Andreas

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Abstract 652: An androgen receptor-associated transcription factor regulates fatty acid metabolism driving tumor growth in androgen receptor-positive breast cancer by Neuberth, Sarah-Jane, Schumacher, Corinna, Snaebjörnsson, Marteinn Thor, Würth, Roberto, Zickgraf, Franziska Maria, Kossi, Ornella, Geist, Felix, Geist, Andrea, Thiel, Vera, Schwickert, Jonas, Falcone, Mattia, Saini, Massimo, Schulze, Almut, Trumpp, Andreas, Sprick, Martin R.

“…Abstract Despite advances in the treatment of breast cancer, it is still the second leading cause of cancer-related death in women worldwide. A large number of…”
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Erratum: Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer by Magnani, Luca, Frigè, Gianmaria, Gadaleta, Raffaella Maria, Corleone, Giacomo, Fabris, Sonia, Kempe, Mannus H, Vershure, Pernette J, Barozzi, Iros, Vircillo, Valentina, Hong, Sung-Pil, Perone, Ylenia, Saini, Massimo, Trumpp, Andreas, Viale, Giuseppe, Neri, Antonino, Ali, Simak, Colleoni, Marco Angelo, Pruneri, Giancarlo, Minucci, Saverio

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Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ER[alpha] metastatic breast cancer by Magnani, Luca, Frigè, Gianmaria, Gadaleta, Raffaella Maria, Corleone, Giacomo, Fabris, Sonia, Kempe, Mannus H, Vershure, Pernette J, Barozzi, Iros, Vircillo, Valentina, Hong, Sung-Pil, Perone, Ylenia, Saini, Massimo, Trumpp, Andreas, Viale, Giuseppe, Neri, Antonino, Ali, Simak, Colleoni, Marco Angelo, Pruneri, Giancarlo, Minucci, Saverio

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