Search Results - "Saindane, Manohar T."

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model by Lieber, Carolin M., Cox, Robert M., Sourimant, Julien, Wolf, Josef D., Juergens, Kate, Phung, Quynh, Saindane, Manohar T., Smith, Meghan K., Sticher, Zachary M., Kalykhalov, Alexander A., Natchus, Michael G., Painter, George R., Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.

“…SARS-CoV-2 variants of concern (VOC) have triggered infection waves. Oral antivirals such as molnupiravir promise to improve disease management, but efficacy…”
Get full text

ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens by Squires, Katherine E, Mayers, Douglas L, Bluemling, Gregory R, Kolykhalov, Alexander A, Guthrie, David B, Reddy, Prabhakar, Mitchell, Debbie G, Saindane, Manohar T, Sticher, Zachary M, Edpuganti, Vindhya, De La Rosa, Abel

“…ATI-2173 is a novel liver-targeted molecule designed to deliver the 5′-monophosphate of clevudine for the treatment of chronic hepatitis B infection. Unlike…”
Get full text

Asymmetric synthesis of host-directed inhibitors of myxoviruses by Moore, Terry W, Sana, Kasinath, Yan, Dan, Thepchatri, Pahk, Ndungu, John M, Saindane, Manohar T, Lockwood, Mark A, Natchus, Michael G, Liotta, Dennis C, Plemper, Richard K, Snyder, James P, Sun, Aiming

“…High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza…”
Get full text

Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine by Westover, Jonna B, Jung, Kie Hoon, Alkan, Cigdem, Boardman, Kirsten M, Van Wettere, Arnaud J, Martens, Craig, Rojas, Inioska, Hicks, Philip, Thomas, Aaron J, Saindane, Manohar T, Bluemling, Gregory R, Mao, Shuli, Kolykhalov, Alexander A, Natchus, Michael G, Bates, Paul, Painter, George R, Ikegami, Tetsuro, Gowen, Brian B

“…Heartland virus (HRTV) is an emerging tick-borne bandavirus that causes a febrile illness of varying severity in humans, with cases reported in eastern and…”
Get full text

4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses by Lieber, Carolin M, Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M, Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K, Jones, Cheryl A, Sticher, Zachary M, Kolykhalov, Alexander A, Saindane, Manohar T, Tompkins, Stephen M, Planz, Oliver, Painter, George R, Natchus, Michael G, Sakamoto, Kaori, Plemper, Richard K

“…Influenza outbreaks are associated with substantial morbidity, mortality and economic burden. Next generation antivirals are needed to treat seasonal…”
Get full text

Development of a novel progesterone analog in the treatment of traumatic brain injury by Sayeed, Iqbal, Wali, Bushra, Guthrie, David B., Saindane, Manohar T., Natchus, Michael G., Liotta, Dennis C., Stein, Donald G.

“…Although systemic progesterone (PROG) treatment has been shown to be neuroprotective by many laboratories and in multiple animal models of brain injury…”
Get full text

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties by Miller, Eric J, Jecs, Edgars, Truax, Valarie M, Katzman, Brooke M, Tahirovic, Yesim A, Wilson, Robert J, Kuo, Katie M, Kim, Michelle B, Nguyen, Huy H, Saindane, Manohar T, Zhao, Huanyu, Wang, Tao, Sum, Chi S, Cvijic, Mary E, Schroeder, Gretchen M, Wilson, Lawrence J, Liotta, Dennis C

“…CXCR4 is a seven-transmembrane receptor expressed by hematopoietic stem cells and progeny, as well as by ≥48 different cancers types. CXCL12, the only…”
Get full text

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model by Krumm, Stefanie A, Yan, Dan, Hovingh, Elise S, Evers, Taylor J, Enkirch, Theresa, Reddy, G Prabhakar, Sun, Aiming, Saindane, Manohar T, Arrendale, Richard F, Painter, George, Liotta, Dennis C, Natchus, Michael G, von Messling, Veronika, Plemper, Richard K

“…Measles virus is a highly infectious morbillivirus responsible for major morbidity and mortality in unvaccinated humans. The related, zoonotic canine distemper…”
Get more information

Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure–Activity Relationships, and Pharmacokinetics by Ndungu, J. Maina, Krumm, Stefanie A, Yan, Dan, Arrendale, Richard F, Reddy, G. Prabhakar, Evers, Taylor, Howard, Randy, Natchus, Michael G, Saindane, Manohar T, Liotta, Dennis C, Plemper, Richard K, Snyder, James P, Sun, Aiming

“…The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric morbidity and mortality worldwide. In an effort to provide…”
Get full text

Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists by Truax, Valarie M, Zhao, Huanyu, Katzman, Brooke M, Prosser, Anthony R, Alcaraz, Ana A, Saindane, Manohar T, Howard, Randy B, Culver, Deborah, Arrendale, Richard F, Gruddanti, Prahbakar R, Evers, Taylor J, Natchus, Michael G, Snyder, James P, Liotta, Dennis C, Wilson, Lawrence J

“…A de novo hit-to-lead effort involving the redesign of benzimidazole-containing antagonists of the CXCR4 receptor resulted in the discovery of a novel series…”
Get full text

A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor by Qian, Xinhua, Zheng, Bin, Burke, Brian, Saindane, Manohar T, Kronenthal, David R

“…A highly stereoselective synthesis of the novel tryptase inhibitor BMS-262084 was developed. Key to this synthesis was the discovery and development of a…”
Get full text

Scale-Up Preparation of Best-In-Class Orally Bioavailable CXCR4 Antagonist EMU-116 in an Academic Setting by Jacobs, Leon, Miller, Eric J., Wilson, Robert J., Jecs, Edgars, Joseph Tholath, Paul, Nguyen, Huy H., Saindane, Manohar T., Altas-Tahirovic, Yesim, Wilson, Lawrence J., Liotta, Dennis C.

“…CXCR4 is a seven-transmembrane chemokine receptor that is intimately involved in stem cell niche maintenance and immune cell trafficking. Among several other…”
Get full text

A synthetic route to forskolin by Ziegler, Frederick E, Jaynes, Burton H, Saindane, Manohar T

Get full text

An Efficient Large Scale Synthesis of 4-Isopropyl- and 4-Isopropyl-6-methoxybenzisothiazolones. [Erratum to document cited in CA122:160528] by Desai, Ranjit C, Hlasta, Dennis J, Monsour, George, Saindane, Manohar T

Get full text

Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents by Reuman, Michael, Daum, Sol J, Singh, Baldev, Wentland, Mark P, Perni, Robert B, Pennock, Patrick, Carabateas, Philip M, Gruett, Monte D, Saindane, Manohar T, Dorff, Peter H, Coughlin, Susan A, Sedlock, David M, Rake, James B, Lesher, George Y

“…The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has…”
Get full text

An Efficient Large Scale Synthesis of 4-Isopropyl- and 4-Isopropyl-6-methoxybenzisothiazolones by Desai, Ranjit C., Hlasta, Dennis J., Monsour, George, Saindane, Manohar T.

Get full text

4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: A Novel Class III Antiarrhythmic Agents by Johnson, Robert E, Silver, Paul J, Becker, Russell, Birsner, Nancy C, Bohnet, Eric A, Briggs, G. Maurice, Busacca, Carl A, Canniff, Paul, Carabateas, Philip M, D'Ambra, Thomas, Dundore, Ronald L, Dung, Jen-Sen, Chadwick, Christopher C, Ezrin, Alan M, Gorczyca, William, Habeeb, Peter G, Horan, Patrick, Krafte, Douglas S, Pelling, Gary, O'Connor, Bernard, Saindane, Manohar T, Schlegel, Donald C, Stankus, Gerald P, Swestock, John, Volberg, Walter A

“…A series of 4,5-dihydro-3-[2-(methanesulfonamidophenyl)ethyl]-1-phenyl- 1H-2,4-benzodiazepines has been identified as potential antiarrhythmic agents that…”
Get full text