Search Results - "Sailem, Heba"

Identification of clinically predictive metagenes that encode components of a network coupling cell shape to transcription by image-omics by Sailem, Heba Z, Bakal, Chris

“…The associations between clinical phenotypes (tumor grade, survival) and cell phenotypes, such as shape, signaling activity, and gene expression, are the basis…”
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KCML: a machine‐learning framework for inference of multi‐scale gene functions from genetic perturbation screens by Sailem, Heba Z, Rittscher, Jens, Pelkmans, Lucas

“…Characterising context‐dependent gene functions is crucial for understanding the genetic bases of health and disease. To date, inference of gene functions from…”
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Analysis of live cell images: Methods, tools and opportunities by Nketia, Thomas A., Sailem, Heba, Rohde, Gustavo, Machiraju, Raghu, Rittscher, Jens

“…•Advances in microscopy, biosensors and cell culturing have transformed live cell imaging.•Today, live cell imaging plays an important role in basic biology…”
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Morphological landscape of endothelial cell networks reveals a functional role of glutamate receptors in angiogenesis by Sailem, Heba Z., Al Haj Zen, Ayman

“…Angiogenesis plays a key role in several diseases including cancer, ischemic vascular disease, and Alzheimer’s disease. Chemical genetic screening of…”
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Visualizing cellular imaging data using PhenoPlot by Sailem, Heba Z., Sero, Julia E., Bakal, Chris

“…Visualization is essential for data interpretation, hypothesis formulation and communication of results. However, there is a paucity of visualization methods…”
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A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes by Yin, Zheng, Sadok, Amine, Sailem, Heba, McCarthy, Afshan, Xia, Xiaofeng, Li, Fuhai, Garcia, Mar Arias, Evans, Louise, Barr, Alexis R., Perrimon, Norbert, Marshall, Christopher J., Wong, Stephen T. C., Bakal, Chris

“…The way in which cells adopt different morphologies is not fully understood. Cell shape could be a continuous variable or restricted to a set of discrete…”
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Visualizing quantitative microscopy data: History and challenges by Sailem, Heba Z, Cooper, Sam, Bakal, Chris

“…Data visualization is a fundamental aspect of science. In the context of microscopy-based studies, visualization typically involves presentation of the images…”
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Efficient Bayesian inference for mechanistic modelling with high-throughput data by Martina Perez, Simon, Sailem, Heba, Baker, Ruth E.

“…Bayesian methods are routinely used to combine experimental data with detailed mathematical models to obtain insights into physical phenomena. However, the…”
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DeepScratch: Single-cell based topological metrics of scratch wound assays by Javer, Avelino, Rittscher, Jens, Sailem, Heba Z.

“…Changes in tissue architecture and multicellular organisation contribute to many diseases, including cancer and cardiovascular diseases. Scratch wound assay is…”
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Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib by Montenegro, Raquel Carvalho, Howarth, Alison, Ceroni, Alessandro, Fedele, Vita, Farran, Batoul, Mesquita, Felipe Pantoja, Frejno, Martin, Berger, Benedict-Tilman, Heinzlmeir, Stephanie, Sailem, Heba Z, Tesch, Roberta, Ebner, Daniel, Knapp, Stefan, Burbano, Rommel, Kuster, Bernhard, Müller, Susanne

“…Gastric cancer (GC) remains the third leading cause of cancer-related death despite several improvements in targeted therapy. There is therefore an urgent need…”
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ShapoGraphy: A User-Friendly Web Application for Creating Bespoke and Intuitive Visualisation of Biomedical Data by Khawatmi, Muhammed, Steux, Yoann, Zourob, Saddam, Sailem, Heba Z

“…Effective visualisation of quantitative microscopy data is crucial for interpreting and discovering new patterns from complex bioimage data. Existing…”
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Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity by Sailem, Heba, Bousgouni, Vicky, Cooper, Sam, Bakal, Chris

“…One goal of cell biology is to understand how cells adopt different shapes in response to varying environmental and cellular conditions. Achieving a…”
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Evolution and impact of high content imaging by Way, Gregory P, Sailem, Heba, Shave, Steven, Kasprowicz, Richard, Carragher, Neil O

“…The field of high content imaging has steadily evolved and expanded substantially across many industry and academic research institutions since it was first…”
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Cell shape and the microenvironment regulate nuclear translocation of NF‐κB in breast epithelial and tumor cells by Sero, Julia E, Sailem, Heba Zuhair, Ardy, Rico Chandra, Almuttaqi, Hannah, Zhang, Tongli, Bakal, Chris

“…Although a great deal is known about the signaling events that promote nuclear translocation of NF‐κB, how cellular biophysics and the microenvironment might…”
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HighVia-A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity by Howarth, Alison, Schröder, Martin, Montenegro, Raquel C, Drewry, David H, Sailem, Heba, Millar, Val, Müller, Susanne, Ebner, Daniel V

“…High-content screening to monitor disease-modifying phenotypes upon small-molecule addition has become an essential component of many drug and target discovery…”
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Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis by Natrajan, Rachael, Sailem, Heba, Mardakheh, Faraz K, Arias Garcia, Mar, Tape, Christopher J, Dowsett, Mitch, Bakal, Chris, Yuan, Yinyin

“…The intra-tumor diversity of cancer cells is under intense investigation; however, little is known about the heterogeneity of the tumor microenvironment that…”
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Proteomics profiling of interactome dynamics by colocalisation analysis (COLA) by Mardakheh, Faraz K, Sailem, Heba Z, Kümper, Sandra, Tape, Christopher J, McCully, Ryan R, Paul, Angela, Anjomani-Virmouni, Sara, Jørgensen, Claus, Poulogiannis, George, Marshall, Christopher J, Bakal, Chris

“…Localisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of…”
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Abstract 216: Functional annotations of membrane transport genes using genetic perturbation screens by Sailem, Heba

“…Abstract Dysregulation of membrane transport and ion channels genes have been associated with through their role in cellular communication, regulation of cell…”
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High-Content Imaging to Phenotype Human Primary and iPSC-Derived Cells by Veschini, Lorenzo, Sailem, Heba, Malani, Disha, Pietiäinen, Vilja, Stojiljkovic, Ana, Wiseman, Erika, Danovi, Davide

“…Increasingly powerful microscopy, liquid handling, and computational techniques have enabled cell imaging in high throughput. Microscopy images are quantified…”
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Malignant Mesothelioma subtyping via sampling driven multiple instance prediction on tissue image and cell morphology data by Eastwood, Mark, Marc, Silviu Tudor, Gao, Xiaohong, Sailem, Heba, Offman, Judith, Karteris, Emmanouil, Fernandez, Angeles Montero, Jonigk, Danny, Cookson, William, Moffatt, Miriam, Popat, Sanjay, Minhas, Fayyaz, Robertus, Jan Lukas

“…Malignant Mesothelioma is a difficult to diagnose and highly lethal cancer usually associated with asbestos exposure. It can be broadly classified into three…”
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