Search Results - "Saif, M Wasif"

Pharmacokinetically Guided Dose Adjustment of 5-Fluorouracil: A Rational Approach to Improving Therapeutic Outcomes by Saif, M. Wasif, Choma, Adrienne, Salamone, Salvatore J., Chu, Edward

“…Chemotherapy dosing of the fluoropyrimidine 5-fluorouracil (5-FU) is currently based on body surface area. However, body surface area–based dosing has been…”
Get full text

Safety and Efficacy of Oxaliplatin and Fluoropyrimidine Regimens With or Without Bevacizumab As First-Line Treatment of Metastatic Colorectal Cancer: Results of the TREE Study by HOCHSTER, Howard S, HART, Lowell L, SCHWARTZBERG, Lee, HEDRICK, Eric, RAMANATHAN, Ramesh K, CHILDS, Barrett H, HAINSWORTH, John D, COHN, Allen L, WONG, Lucas, FEHRENBACHER, Louis, ABUBAKR, Yousif, WASIF SAIF, M

“…To evaluate the safety and efficacy of three oxaliplatin and fluoropyrimidine regimens, with or without bevacizumab, as first-line treatment for metastatic…”
Get full text

The Role of Src in Colon Cancer and Its Therapeutic Implications by Chen, Jiezhong, Elfiky, Aymen, Han, Mei, Chen, Chen, Saif, M. Wasif

“…Abstract Src is a member of a superfamily of membrane-associated nonreceptor protein tyrosine kinases. It is stimulated by receptors of growth hormone,…”
Get full text

The role of mTOR in the management of solid tumors: An overview by Strimpakos, Alex S, Karapanagiotou, Eleni M, Saif, M. Wasif, Syrigos, Kostas N

“…Summary Mammalian target of rapamycin (mTOR) is a key protein kinase controlling signal transduction from various growth factors and upstream proteins to the…”
Get full text

Neoadjuvant therapy for pancreatic cancer: an ongoing debate by Russo, Suzanne, Wasif Saif, M.

Get full text

Small cell carcinoma of the colon arising in a carcinoid tumor by Saif, M Wasif

“…Small cell carcinomas of the gastrointestinal tract are rare and clinically aggressive tumors. A case is presented of a 70 year-old woman who presented with…”
Get full text

Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature by Saif, M Wasif

“…Adenocarcinoma ex goblet cell carcinoid is a rare neoplasm of appendiceal origin that contains features of both carcinoid tumor and adenocarcinoma. We report…”
Get full text

Gastric cancer and trastuzumab: first biologic therapy in gastric cancer by Gunturu, Krishna S., Woo, Yanghee, Beaubier, Nike, Remotti, Helen E., Saif, M. Wasif

“…Gastric cancer remains difficult to cure and has a poor overall prognosis. Chemotherapy and multimodality therapy has shown some benefit in the treatment of…”
Get full text

Phase I/II Study of PHY906/Capecitabine in Advanced Hepatocellular Carcinoma by Yen, Yun, So, Samuel, Rose, Michal, Saif, M Wasif, Chu, Edward, Liu, Shwu-Huey, Foo, Angeline, Jiang, Zaoli, Su, Tahmun, Cheng, Yung-Chi

“…PHY906 is a Chinese medicine formula with claims for the treatment of severe gastrointestinal distress. PHY906 enhanced the therapeutic index of various…”
Get full text

Does erlotinib restore chemosensitivity to chemotherapy in pancreatic cancer? A case series by Saif, M Wasif

“…Erlotinib (Tarceva) in combination with gemcitabine is indicated for first-line treatment of patients with locally advanced, unresectable or metastatic…”
Get full text

Phase II study of intravenous TZT‐1027 in patients with advanced or metastatic soft‐tissue sarcomas with prior exposure to anthracycline‐based chemotherapy by Patel, Shreyaskumar, Keohan, Mary Louise, Saif, M. Wasif, Rushing, Daniel, Baez, Luis, Feit, Kevie, DeJager, Robert, Anderson, Sibyl

“…BACKGROUND. TZT‐1027, a novel chemotherapeutic agent, is derived from dolastatin 10, and blocks cells during G2/M‐phase by interfering with microtubule…”
Get full text

PET scanning: worth the cost in cancer? Not for all cancers--it's not reliable enough yet by Krishnamoorthy, Saravanan K, Saif, M Wasif

Get more information

Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis by Saif, M-Wasif, Khubchandani, Sapna, Walczak, Marek

“…Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma. More than 50% of patients have some site of extra-nodal involvement at…”
Get full text

A Phase I/II Open-Label Multicenter Single-Arm Study of FABLOx (Metronomic 5-Fluorouracil Plus nab -Paclitaxel, Bevacizumab, Leucovorin, and Oxaliplatin) in Patients with Metastatic Pancreatic Cancer by Sahai, Vaibhav, Saif, M. Wasif, Kalyan, Aparna, Philip, Philip A., Rocha-Lima, Caio M., Ocean, Allyson, Ondovik, Michael S., Simeone, Diane M., Banerjee, Sibabrata, Bhore, Rafia, Louis, Chrystal U., Picozzi, Vincent

“…Purpose: To evaluate safety and preliminary efficacy of metronomic 5-fluorouracil plus nab-paclitaxel, bevacizumab, leucovorin, and oxaliplatin (FABLOx) in…”
Get full text

Phase I Study of Capecitabine With Concomitant Radiotherapy for Patients With Locally Advanced Pancreatic Cancer: Expression Analysis of Genes Related to Outcome by WASIF SAIF, M, ELOUBEIDI, Mohammaed A, RUSSO, Suzanne, STEG, Adam, THORNTON, Jennifer, FIVEASH, John, CARPENTER, Mark, BLANQUICETT, Carmello, DIASIO, Robert B, JOHNSON, Martin R

“…To establish the feasibility of capecitabine with concurrent radiotherapy (XRT) in patients with locally advanced (LA) pancreatic cancer and evaluate the…”
Get full text

Primary Peritoneal Carcinoma in Complete Remission: a Case Report by RAMOS, Jorge, GUNTURU, Krishna S, KRISHNAMOORTHY, Saravanan, KENNEL, Barton, WASIF SAIF, M

“…Primary peritoneal carcinoma (PPCa) is a relatively uncommonly diagnosed tumor. It has a similar presentation to ovarian cancer. PPCa has a poor prognosis with…”
Get full text

Bolus 5-Fluorouracil as an Alternative Modality to Infusion 5-Fluorouracil in a Patient with Rectal Cancer and Capecitabine-induced Cardiotoxicity by Shaib, Walid, Lee, Veronica, Saif, M Wasif

“…5-Fluorouracil (5-FU) is the backbone of the chemotherapy regimens approved for treatment of colorectal cancer. Incidence of cardiotoxicity associated with…”
Get full text

Erlotinib: the first biologic in the management of pancreatic cancer by Saif, M Wasif

“…Pancreatic cancer remains a major therapeutic challenge largely characterized by chemotherapy-refractory disease and poor responses to currently available…”
Get more information

Safety and Efficacy of Everolimus in Adult Patients with Neuroendocrine Tumors by Oberstein, Paul E., Saif, M. Wasif

“…Neuroendocrine tumors (NETs) consist of a diverse family of tumors which are derived from the neuroendocrine system. Most NETs are well or moderately…”
Get full text

An Adverse Interaction Between Warfarin and Fluoropyrimidines Revisited by Saif, M. Wasif

“…Regimens based on flouropyrimidines (eg, 5-fluorouracil [5-FU] and capecitabine) are the mainstay of chemotherapy for several malignancies, including colon,…”
Get full text