Search Results - "Saied, Essa M"

New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study by Gaber, Ahmed, Refat, Moamen S, Belal, Arafa A M, El-Deen, Ibrahim M, Hassan, Nader, Zakaria, Rozan, Alhomrani, Majid, Alamri, Abdulhakeem S, Alsanie, Walaa F, M Saied, Essa

“…Herein, we report the synthesis of eight new mononuclear and binuclear Co , Ni , Cu , and Zn methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining…”
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Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases by Lone, Museer A., Hülsmeier, Andreas J., Saied, Essa M., Karsai, Gergely, Arenz, Christoph, von Eckardstein, Arnold, Hornemann, Thorsten

“…Sphingolipids (SLs) are chemically diverse lipids that have important structural and signaling functions within mammalian cells. SLs are commonly defined by…”
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Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx by Saied, Essa M., Arenz, Christoph

“…Sphingolipids are ubiquitous in eukaryotic plasma membranes and play major roles in human and animal physiology and disease. This class of lipids is usually…”
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Novel Papaverine Metal Complexes with Potential Anticancer Activities by Gaber, Ahmed, Alsanie, Walaa F, Kumar, Deo Nandan, Refat, Moamen S, Saied, Essa M

“…Cancer is one of the leading causes of death worldwide. Although several potential therapeutic agents have been developed to efficiently treat cancer, some…”
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Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis by Ahmed, Eman A, El-Derany, Marwa O, Anwar, Ali Mostafa, Saied, Essa M, Magdeldin, Sameh

“…With the rising incidence of hepatocellular carcinoma (HCC) from non-alcoholic steatohepatitis (NASH), identifying new metabolic readouts that function in…”
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Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT) by Samaha, Doaa, Hamdo, Housam H., Cong, Xiaojing, Schumacher, Fabian, Banhart, Sebastian, Aglar, Öznur, Möller, Heiko M., Heuer, Dagmar, Kleuser, Burkhard, Saied, Essa M., Arenz, Christoph

“…Ceramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting…”
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The Catalytic Activity of Biosynthesized Magnesium Oxide Nanoparticles (MgO-NPs) for Inhibiting the Growth of Pathogenic Microbes, Tanning Effluent Treatment, and Chromium Ion Removal by Ebrahim Saied, Ahmed M. Eid, Saad El-Din Hassan, Salem S. Salem, Ahmed A. Radwan, Mahmoud Halawa, Fayez M. Saleh, Hosam A. Saad, Essa M. Saied, Amr Fouda

“…Magnesium oxide nanoparticles (MgO-NPs) were synthesized using the fungal strain Aspergillus terreus S1 to overcome the disadvantages of chemical and physical…”
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Novel 1,3-Thiazole Analogues with Potent Activity against Breast Cancer: A Design, Synthesis, In Vitro, and In Silico Study by Salem, Manar G., El-Maaty, Dina M. Abu, El-Deen, Yassmina I. Mohey, Elesawy, Basem H., Askary, Ahmad El, Saleh, Asmaa, Saied, Essa M., Behery, Mohammed El

“…Breast cancer is the most common cancer in women, responsible for over half a million deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen- and…”
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Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments by Khirallah, Salma M., Ramadan, Heba M. M., Shawky, Ahmed, Qahl, Safa H., Baty, Roua S., Alqadri, Nada, Alsuhaibani, Amnah Mohammed, Jaremko, Mariusz, Emwas, Abdul-Hamid, Saied, Essa M.

“…Inflammation is the main cause of several autoimmune diseases, including type I diabetes, rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid,…”
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Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications by Khalifa, Shaden A M, Shedid, Eslam S, Saied, Essa M, Jassbi, Amir Reza, Jamebozorgi, Fatemeh H, Rateb, Mostafa E, Du, Ming, Abdel-Daim, Mohamed M, Kai, Guo-Yin, Al-Hammady, Montaser A M, Xiao, Jianbo, Guo, Zhiming, El-Seedi, Hesham R

“…Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also…”
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Novel Exopolysaccharide from Marine Bacillus subtilis with Broad Potential Biological Activities: Insights into Antioxidant, Anti-Inflammatory, Cytotoxicity, and Anti-Alzheimer Activity by Abdel-Wahab, Basel A, F Abd El-Kareem, Hanaa, Alzamami, Ahmad, A Fahmy, Cinderella, H Elesawy, Basem, Mostafa Mahmoud, Maged, Ghareeb, Ahmed, El Askary, Ahmad, H Abo Nahas, Hebatallah, G M Attallah, Nashwah, Altwaijry, Najla, M Saied, Essa

“…In the presented study, strain AG4 isolated from marine was identified based on morphological, physiological, phylogenetic characteristics and an examination…”
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Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties by Santos, Tania C B, Vaz, Alexandra, Ventura, Ana E, M Saied, Essa, Arenz, Christoph, Fedorov, Aleksander, Prieto, Manuel, Silva, Liana C

“…Compared to the canonical sphingoid backbone of sphingolipids (SLs), atypical long-chain bases (LCBs) lack C1-OH (1-deoxy-LCBs) or C1-CH OH…”
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Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway by Alecu, Irina, Othman, Alaa, Penno, Anke, Saied, Essa M., Arenz, Christoph, von Eckardstein, Arnold, Hornemann, Thorsten

“…The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine…”
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Editorial: Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: current perspectives and new challenges by Abdel-Wahab, Basel A, Helmy, Yosra A, Saied, Essa M

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Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy by Vasiliauskaité-Brooks, Ieva, Healey, Robert D., Rochaix, Pascal, Saint-Paul, Julie, Sounier, Rémy, Grison, Claire, Waltrich-Augusto, Thierry, Fortier, Mathieu, Hoh, François, Saied, Essa M., Arenz, Christoph, Basu, Shibom, Leyrat, Cédric, Granier, Sébastien

“…Alkaline ceramidases (ACERs) are a class of poorly understood transmembrane enzymes controlling the homeostasis of ceramides. They are implicated in human…”
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A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19 by Saied, Essa M., El-Maradny, Yousra A., Osman, Alaa A., Darwish, Amira M. G., Abo Nahas, Hebatallah H., Niedbała, Gniewko, Piekutowska, Magdalena, Abdel-Rahman, Mohamed A., Balbool, Bassem A., Abdel-Azeem, Ahmed M.

“…In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from…”
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Vitamin D3 Prevents the Deleterious Effects of Testicular Torsion on Testis by Targeting miRNA-145 and ADAM17: In Silico and In Vivo Study by Mohamed, Doaa I, Abou-Bakr, Doaa A, Ezzat, Samar F, El-Kareem, Hanaa F Abd, Nahas, Hebatallah H Abo, Saad, Hosam A, Mehana, Amir E, Saied, Essa M

“…Testicular torsion (TT) is the most common urological emergency in children and young adults that can lead to infertility in many cases. The…”
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Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens by Helmy, Yosra A, Taha-Abdelaziz, Khaled, Hawwas, Hanan Abd El-Halim, Ghosh, Soumya, AlKafaas, Samar Sami, Moawad, Mohamed M M, Saied, Essa M, Kassem, Issmat I, Mawad, Asmaa M M

“…Antimicrobial resistance (AMR) is one of the most important global public health problems. The imprudent use of antibiotics in humans and animals has resulted…”
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Facile Synthesis of the CERT Inhibitor HPA-12 and Some Novel Derivatives by Saied, Essa M., Diederich, Stephanie, Arenz, Christoph

“…HPA‐12 is an inhibitor of CERT‐mediated non‐vesicular transport of ceramide from the ER membranes to the Golgi apparatus. The inhibitor effectively blocks the…”
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Elucidating the chemical structure of native 1-deoxysphingosine[S] by Steiner, Regula, Saied, Essa M., Othman, Alaa, Arenz, Christoph, Maccarone, Alan T., Poad, Berwyck L.J., Blanksby, Stephen J., von Eckardstein, Arnold, Hornemann, Thorsten

“…The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group…”
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