Search Results - "Said, Riham S."
-
1
Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure: Emphasis on TGF-β/MAPKs signaling pathway
Published in Biomedicine & pharmacotherapy (01-01-2019)“…[Display omitted] Radiotherapy is one of the most relevant treatment modalities for various types of malignancies. However, it causes premature ovarian failure…”
Get full text
Journal Article -
2
Coenzyme Q10 mitigates ionizing radiation-induced testicular damage in rats through inhibition of oxidative stress and mitochondria-mediated apoptotic cell death
Published in Toxicology and applied pharmacology (15-11-2019)“…Radiotherapy is a common treatment modality for cancer patients; however, its use is limited by decreasing the probability of fertility in male cancer…”
Get full text
Journal Article -
3
Mechanistic perspective of protective effects of resveratrol against cisplatin-induced ovarian injury in rats: emphasis on anti-inflammatory and anti-apoptotic effects
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-10-2019)“…Chemotherapeutic platinum-containing drugs are widely used to treat a variety of cancer types; however, they cause ovarian failure and infertility. The aim of…”
Get full text
Journal Article -
4
Bone Marrow-Derived Mesenchymal Stem Cells Reverse Radiotherapy-Induced Premature Ovarian Failure: Emphasis on Signal Integration of TGF-β, Wnt/β-Catenin and Hippo Pathways
Published in Stem cell reviews and reports (01-08-2021)“…Radiotherapy is an indispensable cancer treatment approach. However, it is associated with hazardous consequences on multiple organs characterized by insidious…”
Get more information
Journal Article -
5
Sodium selenite improves folliculogenesis in radiation-induced ovarian failure: a mechanistic approach
Published in PloS one (06-12-2012)“…Radiotherapy is a major factor contributing to female infertility by inducing premature ovarian failure (POF). Therefore, the need for an effective…”
Get full text
Journal Article -
6
Protective effects of Brownea grandiceps (Jacq.) against ϒ-radiation-induced enteritis in rats in relation to its secondary metabolome fingerprint
Published in Biomedicine & pharmacotherapy (01-02-2022)“…Radiation enteritis is the most common complication of radiotherapy in patients with pelvic malignancies. Thus, the radioprotective activity of the total…”
Get full text
Journal Article -
7
Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways
Published in International immunopharmacology (01-03-2021)“…•CoQ10 maintained the integrity of the intestinal mucosa after radiation exposure.•CoQ10 inhibited intestinal oxidative damage and restored the antioxidant…”
Get full text
Journal Article -
8
Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway
Published in Toxicology and applied pharmacology (01-08-2024)“…Radiation-induced cognitive impairment has recently fueled scientific interest with an increasing prevalence of cancer patients requiring whole brain…”
Get full text
Journal Article -
9
Hesperidin attenuates radiation-induced ovarian failure in rats: Emphasis on TLR-4/NF-ĸB signaling pathway
Published in Toxicology and applied pharmacology (01-11-2024)“…Young women suffering from premature ovarian failure after radiotherapy carry a huge burden in the field of cancer therapy including reproductive loss,…”
Get full text
Journal Article -
10
Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: co-operative role of ER-β, TGF-β, and FOXL-2
Published in Scientific reports (11-08-2020)“…Radiotherapy is a well-known cause of premature ovarian failure (POF). Therefore, we investigated the molecular influence of genistein (GEN) on the ovarian…”
Get full text
Journal Article -
11
Novel molecular mechanisms underlying the ameliorative effect of N-acetyl-L-cysteine against ϒ-radiation-induced premature ovarian failure in rats
Published in Ecotoxicology and environmental safety (15-12-2020)“…Radiotherapy represents a critical component in cancer treatment. However, premature ovarian failure (POF) is a major hurdle of deleterious off-target effects…”
Get full text
Journal Article -
12
Promising drug repurposing approach targeted for cytokine storm implicated in SARS-CoV-2 complications
Published in Immunopharmacology and immunotoxicology (04-07-2021)“…A global threat has emerged in 2019 due to the rapid spread of Coronavirus disease (COVID-19). As of January 2021, the number of cases worldwide reached 103…”
Get full text
Journal Article -
13
Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking
Published in Archiv der Pharmazie (Weinheim) (01-11-2024)“…Hibiscus species (Malvaceae) possess a plethora of appealing pharmacological activities with an extended history of customary use in diverse medical…”
Get full text
Journal Article -
14
Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model
Published in Inflammopharmacology (01-02-2021)“…Gastric ulcer is a very common illness that adversely affects a significant number of people all over the globe. Phytochemical investigation of P. glabra leaf…”
Get full text
Journal Article