Search Results - "Said, Meerit"

IMPDH1 retinal variants control filament architecture to tune allosteric regulation by Burrell, Anika L., Nie, Chuankai, Said, Meerit, Simonet, Jacqueline C., Fernández-Justel, David, Johnson, Matthew C., Quispe, Joel, Buey, Rubén M., Peterson, Jeffrey R., Kollman, Justin M.

“…Inosine-5′-monophosphate dehydrogenase (IMPDH), a key regulatory enzyme in purine nucleotide biosynthesis, dynamically assembles filaments in response to…”
Get full text

Expansive discovery of chemically diverse structured macrocyclic oligoamides by Salveson, Patrick J, Moyer, Adam P, Said, Meerit Y, Gӧkçe, Gizem, Li, Xinting, Kang, Alex, Nguyen, Hannah, Bera, Asim K, Levine, Paul M, Bhardwaj, Gaurav, Baker, David

“…Small macrocycles with four or fewer amino acids are among the most potent natural products known, but there is currently no way to systematically generate…”
Get full text

Exploration of Structured Symmetric Cyclic Peptides as Ligands for Metal-Organic Frameworks by Said, Meerit Y., Kang, Christine S., Wang, Shunzhi, Sheffler, William, Salveson, Patrick J., Bera, Asim K., Kang, Alex, Nguyen, Hannah, Ballard, Ryanne, Li, Xinting, Bai, Hua, Stewart, Lance, Levine, Paul, Baker, David

“…Despite remarkable advances in the assembly of highly structured coordination polymers and metal–organic frameworks, the rational design of such materials…”
Get full text

Binding and sensing diverse small molecules using shape-complementary pseudocycles by An, Linna, Said, Meerit, Tran, Long, Majumder, Sagardip, Goreshnik, Inna, Lee, Gyu Rie, Juergens, David, Dauparas, Justas, Anishchenko, Ivan, Coventry, Brian, Bera, Asim K, Kang, Alex, Levine, Paul M, Alvarez, Valentina, Pillai, Arvind, Norn, Christoffer, Feldman, David, Zorine, Dmitri, Hicks, Derrick R, Li, Xinting, Sanchez, Mariana Garcia, Vafeados, Dionne K, Salveson, Patrick J, Vorobieva, Anastassia A, Baker, David

“…We describe an approach for designing high-affinity small molecule-binding proteins poised for downstream sensing. We use deep learning-generated pseudocycles…”
Get full text

Generation of Potent and Stable GLP‑1 Analogues Via “Serine Ligation” by Levine, Paul M, Craven, Timothy W, Li, Xinting, Balana, Aaron T, Bird, Gregory H, Godes, Marina, Salveson, Patrick J, Erickson, Patrick W, Lamb, Mila, Ahlrichs, Maggie, Murphy, Michael, Ogohara, Cassandra, Said, Meerit Y, Walensky, Loren D, Pratt, Matthew R, Baker, David

“…Peptide and protein bioconjugation technologies have revolutionized our ability to site-specifically or chemoselectively install a variety of functional groups…”
Get full text

Perspective: Successes and Challenges in Developing a New Biomolecular Modeling and Design Summer High School Research Internship by Vater, Ashley, Caster, Ryan, Haddox, Hugh, Olshefsky, Audrey, Said, Meerit, King, Neil P., Siegel, Justin B.

“…In response to the limited research experiences for young scholars during the COVID-19 pandemic and community interest, we developed the Pre-College Rosetta…”
Get full text

Computational Design of Peptides and Proteins for Cyclic Peptide Applications by Said, Meerit

“…Cyclic peptides are a fascinating class of compounds to use in multiple design applications due to their small size and ability to be chemically synthesized…”
Get full text

Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models by Dalbøge, Louise S., Jacobsen, Julie M., Mehrotra, Suneet, Mercer, Aaron J., Cox, Nick, Liu, Fa, Bennett, Camdin M., Said, Meerit, Tang-Christensen, Mads, Raun, Kirsten, Hansen, Jakob L., Grove, Kevin L., Baquero, Arian F.

“…•VGF-derived peptides were synthesized and screened for effects on energy homeostasis.•NERP-1, PGH-NH2, HHPD-41, and TLQP-62 increased activity of hypothalamic…”
Get full text