Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner

Here we provide evidence that both pharmacological and environmental manipulations similarly blunt the cortisol release in response to an acute stressor in adult zebrafish. Different groups of fish were maintained isolated or group-housed in barren or enriched tanks, and then exposed or not to diaze...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 28986
Main Authors:	Giacomini, Ana Cristina V. V., Abreu, Murilo S., Zanandrea, Rodrigo, Saibt, Natália, Friedrich, Maria Tereza, Koakoski, Gessi, Gusso, Darlan, Piato, Angelo L., Barcellos, Leonardo J. G.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28-06-2016 Nature Publishing Group
Subjects:	631/378/1831 631/601/1737 Animal welfare Behavior Hormones Housing conditions Humanities and Social Sciences multidisciplinary Science Science (multidisciplinary)
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Summary:	Here we provide evidence that both pharmacological and environmental manipulations similarly blunt the cortisol release in response to an acute stressor in adult zebrafish. Different groups of fish were maintained isolated or group-housed in barren or enriched tanks, and then exposed or not to diazepam or fluoxetine. Acute stress increased cortisol levels in group-housed zebrafish maintained in barren environment. Single-housed zebrafish displayed a blunted cortisol response to stress. Environmental enrichment also blunted the stress response and this was observed in both isolated and group-housed fish. The same blunting effect was observed in zebrafish exposed to diazepam or fluoxetine. We highlighted environmental enrichment as an alternative and/or complimentary therapeutic for reducing stress and as a promoter of animal welfare.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep28986