Search Results - "Sahu, Avinash Das"

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade by Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael P, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok K, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J, Rodig, Scott, Long, Henry W, Gewurz, Benjamin E, Hodi, F Stephen, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined…”
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Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism by Howard, Alicia D, Wang, Xiaochun, Prasad, Megana, Sahu, Avinash Das, Aniba, Radhouane, Miller, Michael, Hannenhalli, Sridhar, Chang, Yen-Pei Christy

“…For most complex traits, the majority of SNPs identified through genome-wide association studies (GWAS) reside within noncoding regions that have no known…”
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Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy by Sahu, Avinash Das, S Lee, Joo, Wang, Zhiyong, Zhang, Gao, Iglesias‐Bartolome, Ramiro, Tian, Tian, Wei, Zhi, Miao, Benchun, Nair, Nishanth Ulhas, Ponomarova, Olga, Friedman, Adam A, Amzallag, Arnaud, Moll, Tabea, Kasumova, Gyulnara, Greninger, Patricia, Egan, Regina K, Damon, Leah J, Frederick, Dennie T, Jerby‐Arnon, Livnat, Wagner, Allon, Cheng, Kuoyuan, Park, Seung Gu, Robinson, Welles, Gardner, Kevin, Boland, Genevieve, Hannenhalli, Sridhar, Herlyn, Meenhard, Benes, Cyril, Flaherty, Keith, Luo, Ji, Gutkind, J Silvio, Ruppin, Eytan

“…Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating…”
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ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries by Nair, Nishanth Ulhas, Sahu, Avinash Das, Bucher, Philipp, Moret, Bernard M E

“…The advent of high-throughput technologies such as ChIP-seq has made possible the study of histone modifications. A problem of particular interest is the…”
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Study of cell differentiation by phylogenetic analysis using histone modification data by Nair, Nishanth Ulhas, Lin, Yu, Manasovska, Ana, Antic, Jelena, Grnarova, Paulina, Sahu, Avinash Das, Bucher, Philipp, Moret, Bernard M E

“…In cell differentiation, a cell of a less specialized type becomes one of a more specialized type, even though all cells have the same genome. Transcription…”
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CRISPR screens decode cancer cell pathways that trigger γδ T cell detection by Mamedov, Murad R., Vedova, Shane, Freimer, Jacob W., Sahu, Avinash Das, Ramesh, Amrita, Arce, Maya M., Meringa, Angelo D., Ota, Mineto, Chen, Peixin Amy, Hanspers, Kristina, Nguyen, Vinh Q., Takeshima, Kirsten A., Rios, Anne C., Pritchard, Jonathan K., Kuball, Jürgen, Sebestyen, Zsolt, Adams, Erin J., Marson, Alexander

“…γδ T cells are potent anticancer effectors with the potential to target tumours broadly, independent of patient-specific neoantigens or human leukocyte antigen…”
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INCISOR: An Algorithm to Identify Synthetic Rescue Mediators of Resistance to Targeted and Immunotherapy by Wang, Xiaoman, Vizeacoumar, Frederick Sagayaraj, Sahu, Avinash Das

“…Despite the success of targeted therapies including immunotherapies in cancer treatments, tumor resistance to targeted therapies remains a fundamental…”
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Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer by Magen, Assaf, Das Sahu, Avinash, Lee, Joo Sang, Sharmin, Mahfuza, Lugo, Alexander, Gutkind, J. Silvio, Schäffer, Alejandro A., Ruppin, Eytan, Hannenhalli, Sridhar

“…The phenotypic effect of perturbing a gene’s activity depends on the activity level of other genes, reflecting the notion that phenotypes are emergent…”
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A landscape of response to drug combinations in non-small cell lung cancer by Nair, Nishanth Ulhas, Greninger, Patricia, Zhang, Xiaohu, Friedman, Adam A., Amzallag, Arnaud, Cortez, Eliane, Sahu, Avinash Das, Lee, Joo Sang, Dastur, Anahita, Egan, Regina K., Murchie, Ellen, Ceribelli, Michele, Crowther, Giovanna S., Beck, Erin, McClanaghan, Joseph, Klump-Thomas, Carleen, Boisvert, Jessica L., Damon, Leah J., Wilson, Kelli M., Ho, Jeffrey, Tam, Angela, McKnight, Crystal, Michael, Sam, Itkin, Zina, Garnett, Mathew J., Engelman, Jeffrey A., Haber, Daniel A., Thomas, Craig J., Ruppin, Eytan, Benes, Cyril H.

“…Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited efficacy of single agents. The design and testing of combinations are…”
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Clonal tracing reveals diverse patterns of response to immune checkpoint blockade by Gu, Shengqing Stan, Wang, Xiaoqing, Hu, Xihao, Jiang, Peng, Li, Ziyi, Traugh, Nicole, Bu, Xia, Tang, Qin, Wang, Chenfei, Zeng, Zexian, Fu, Jingxin, Meyer, Cliff, Zhang, Yi, Cejas, Paloma, Lim, Klothilda, Wang, Jin, Zhang, Wubing, Tokheim, Collin, Sahu, Avinash Das, Xing, Xiaofang, Kroger, Benjamin, Ouyang, Zhangyi, Long, Henry, Freeman, Gordon J, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple…”
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Immune receptor repertoires in pediatric and adult acute myeloid leukemia by Zhang, Jian, Hu, Xihao, Wang, Jin, Sahu, Avinash Das, Cohen, David, Song, Li, Ouyang, Zhangyi, Fan, Jingyu, Wang, Binbin, Fu, Jingxin, Gu, Shengqing, Sade-Feldman, Moshe, Hacohen, Nir, Li, Wuju, Ying, Xiaomin, Li, Bo, Liu, X Shirley

“…Acute myeloid leukemia (AML), caused by the abnormal proliferation of immature myeloid cells in the blood or bone marrow, is one of the most common hematologic…”
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Supporting the Next Generation of Scientists to Lead Cancer Immunology Research by Alspach, Elise, Chow, Ryan D, Demehri, Shadmehr, Guerriero, Jennifer L, Gujar, Shashi, Hartmann, Felix J, Helmink, Beth A, Hudson, William H, Ho, Won Jin, Ma, Leyuan, Maier, Barbara B, Maltez, Vivien I, Miller, Brian C, Moran, Amy E, Parry, Erin M, Pillai, Padmini S, Rafiq, Sarwish, Reina-Campos, Miguel, Rosato, Pamela C, Rudqvist, Nils-Petter, Ruhland, Megan K, Sagiv-Barfi, Idit, Sahu, Avinash Das, Samstein, Robert M, Schürch, Christian M, Sen, Debattama R, Thommen, Daniela S, Wolf, Yochai, Zappasodi, Roberta

“…Recent success in the use of immunotherapy for a broad range of cancers has propelled the field of cancer immunology to the forefront of cancer research. As…”
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700 Increasing MHC-I expression to potentiate immune checkpoint blockade therapy by Gu, Shengqing, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon, Rodig, Scott, Long, Henry, Gewurz, Benjamin, Stephen Hodi, F., Brown, Myles, Shirley Liu, X

“…BackgroundCancer immunotherapy, especially immune checkpoint blockade (ICB) therapy, is leading to a paradigm shift in cancer treatment, as a small percentage…”
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Genome-wide CRISPR screens reveal metabolic and transcriptional regulation of BTN3A and cancer susceptibility to Vγ9Vδ2 T cell targeting by Mamedov, Murad R, Vedova, Shane, Freimer, Jacob W., Sahu, Avinash Das, Chen, Peixin Amy, Ramesh, Amrita, Hanspers, Kristina, Nguyen, Vinh Q., Adams, Erin J, Marson, Alexander

“…Abstract γδ T cells are potent anti-cancer effectors with potential to target tumors broadly, independent of neoantigens or HLA-background. γδ T cells can…”
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Chromosome 7 gain compensates for chromosome 10 loss in glioma by Nair, Nishanth Ulhas, Schaffer, Alejandro A, Gertz, E Michael, Cheng, Kuoyuan, Zerbib, Johanna, Sahu, Avinash Das, Leor, Gil, Shulman, Eldad D, Aldape, Kenneth D, Ben-David, Uri, Ruppin, Eytan

“…The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most frequent loss-gain co-aneuploidy pair in human cancers. This phenomenon…”
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Abstract 2263: Why does the loss of chromosomes 10 and the gain of 7 co-occur in gliomas by Nair, Nishanth Ulhas, Schäffer, Alejandro A., Gertz, Michael E., Cheng, Kuoyuan, Sahu, Avinash Das, Leor, Gil, Shulman, Eldad D., Aldape, Kenneth D., Ben-David, Uri, Ruppin, Eytan

“…Abstract Introduction: Gliomas, including aggressive forms such as glioblastoma (GBM) and lower-grade gliomas (LGG), present formidable challenges for…”
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Abstract 65: Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade by Gu, Shengqing, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L., Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J., Rodig, Scott J., Long, Henry, Gewurz, Benjamin E., Hodi, F. Stephen, Brown, Myles, Liu, X. Shirley

“…Abstract Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we…”
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A community challenge to predict clinical outcomes after immune checkpoint blockade in non-small cell lung cancer by Mason, Mike, Lapuente-Santana, Óscar, Halkola, Anni S, Wang, Wenyu, Mall, Raghvendra, Xiao, Xu, Kaufman, Jacob, Fu, Jingxin, Pfeil, Jacob, Banerjee, Jineta, Chung, Verena, Chang, Han, Chasalow, Scott D, Lin, Hung Ying, Chai, Rongrong, Yu, Thomas, Finotello, Francesca, Mirtti, Tuomas, Mäyränpää, Mikko I, Bao, Jie, Verschuren, Emmy W, Ahmed, Eiman I, Ceccarelli, Michele, Miller, Lance D, Monaco, Gianni, Hendrickx, Wouter R L, Sherif, Shimaa, Yang, Lin, Tang, Ming, Gu, Shengqing Stan, Zhang, Wubing, Zhang, Yi, Zeng, Zexian, Das Sahu, Avinash, Liu, Yang, Yang, Wenxian, Bedognetti, Davide, Tang, Jing, Eduati, Federica, Laajala, Teemu D, Geese, William J, Guinney, Justin, Szustakowski, Joseph D, Vincent, Benjamin G, Carbone, David P

“…Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results…”
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Epigenomic model of cardiac enhancers with application to genome wide association studies by Sahu, Avinash Das, Aniba, Radhouane, Chang, Yen-Pei Christy, Hannenhalli, Sridhar

“…Mammalian gene regulation is often mediated by distal enhancer elements, in particular, for tissue specific and developmental genes. Computational…”
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Data driven approaches to identify determinants of heart diseases and cancer resistance by Sahu, Avinash Das

“…Cancer and cardio-vascular diseases are the leading causes of death world-wide. Caused by systemic genetic and molecular disruptions in cells, these disorders…”
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